Evaluation of potential eye or skin irritation/corrosion in rabbit exposed to TiO2 photocatalyst (GST)

Abstract

TiO2 NPs photocatalyst is widely used in a variety of applications and products in the environmental and energy fields, including self-cleaning surfaces, air and water purification systems, sterilization, hydrogen evolution, and photoelectrochemical conversion. The possible biological and safety effects of TiO2 dermal exposure and absorption have not been well studied and more investigations on the potential health hazards of the TiO2 are needed. This study aimed to investigate potential effect of local lesions (eye and skin irritation/corrosion) for new TiO2 material powder, GST produced through sludge recycling of the sewage treatment plant in according to the OECD test guideline (TG 404, 405) and imaging evaluation (micro-computed tomography analysis), histopathology examination. Also, P-25, commercial photocatalyst was used to compare with GST. For the eye or skin irritation/corrosion test, the test substances (GST, P-25) showed no irritation/corrosion for local lesions and the GHS category was identified as a “No hazard class”. The imaging analysis indicated that GST did not penetrate or distribute in the local lesions (eye, skin) and the treatment-related effect was not observed in histopathology. Therefore, the present study revealed that new TiO2 powder, GST was considered to be no potential effects (irritation/corrosion), penetration or distribution in the local lesions (eye, skin).

Repeated-dose 28-day dermal toxicity study of TiO2 catalyst (GST) in Sprague-Dawley rats

“…TiO2 material, which is covered in this paper, the new TiO2 material, GST (100% anatase) prepared from the precipitated sludge using TiCl4 used as a coagulant to remove total phosphorus in the wastewater was manufactured to have cost-competitive lower than price of commercial material (P-25, Evonik Corp., a flame-made multiphasic TiO2 nanoparticles containing anatase and rutile) with excellent photocatalytic function [8,9]. We have been studied toxicological test as acute oral / dermal toxicity (TG 402, 423) in female rats by Seol et al [10], eye or skin irritation/corrosion in rabbit (TG 404, 405) by Kim et al [11] and 90-day oral repeated toxicity in rats by Kim et al Through these studies, we confirmed that http://eaht.org GST have no treatment-related effect for oral acute / repeated exposure (90-day, subchronic) or acute dermal and eye or skin. But the study for toxicological information on dermal repeated study (90-day, subchronic) has been not conducted.…”

Reproductive and developmental toxicity screening test of new TiO2 GST in Sprague-Dawley rats

“…New TiO 2 material used in this article, GST (Green Sludge Titanium, 100% anatase) prepared from the precipitated sludge using TiCl 4 used as a coagulant to remove total phosphorus in the wastewater was manufactured to have cost-competitive lower than price of commercial material (P-25, Evonik Corp., a flame-made multiphasic TiO 2 nanoparticles containing anatase and rutile) with excellent photocatalytic function [ 22 , 23 ]. In previous research using GST, we have been studied toxicological test as acute oral / dermal toxicity (TG 402, 423) in female rats by Seol et al [ 24 ], eye or skin irritation/corrosion in rabbit (TG 404, 405) by Kim et al [ 25 ] and 90-day oral repeated toxicity in rats by Kim et al [ 25 ]. Through these studies, we confirmed that GST have no treatment-related effect for oral acute / repeated exposure or acute dermal and eye or skin.…”