Evaluation of preoperative staging for esophageal squamous cell carcinoma

Luo, Lin; He, Liangmei; Gao, Xu; Huang, Xin; Shan, Hong; Luo, Guangyu; Li, Yin; Lin, Shi Yong; Wang, Guo Bao; Rong, Zhang; Xu, Guo Liang; Li, Jian Jun

doi:10.3748/wjg.v22.i29.6683

Cited by 32 publications

(19 citation statements)

References 42 publications

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“…Riddell et al, conducted a study to assess the detection rate of esophageal cancer using high resolution T2-weighted MRI and found that MRI accurately detected only T3 and T4 cases [24]. Other studies showed that the combined T2-weighted and DWI scans detected 33% of T1, 58% of T2, 96% of T3 and 100% of T4 cases of esophageal cancer [25,26]. Cine MRI is a fast-imaging sequence of true steady-state precession that has been explored to dynamically display esophageal tumor and the risk of its invasion along with its motility [27].…”

Section: Discussionmentioning

confidence: 99%

A prospective analysis of the diagnostic accuracy of 3 T MRI, CT and endoscopic ultrasound for preoperative T staging of potentially resectable esophageal cancer

et al. 2020

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Background Patients with esophageal cancer (EC) undergo endoscopic ultrasound and CT based cancer staging. Recent technical developments allow improved MRI quality with diminished motion artifact that may allow MRI to compare favorable to CT for noninvasive staging. Hence the purpose of the study was to assess image quality and diagnostic accuracy of 3 T MRI versus CT and EUS for preoperative T-staging of potentially resectable esophageal cancer. Methods Between October-2014 and December-2017, esophageal cancer patients with T-staging by EUS were enrolled in this prospective study. Post-operative histopathologic T-staging was the reference standard. All participants underwent MRI [T2- multi-shot turbo spin echo sequence (msTSE), diffusion-weighted imaging (DWI), and 3D gradient-echo based sequence (3D-GRE)] and CT [non-contrast and multiphase contrast-enhanced CT scanning] 5.6 + 3.6 days after endoscopy. Surgery was performed within 3.6 + 3.5 days after imaging. Two blinded endoscopists (reader 1 and 2) and radiologists (reader 3 and 4) independently evaluated EUS and CT/MRI, respectively. Considering the clinical relevance, patients were dichotomized into early (T1 and T2) vs late (T3 and T4) stage cancer before assessment. For statistical purpose, the binary decision was defined as the ability of the imaging technique to diagnose early stage/not early stage esophageal cancer. Diagnostic performance of EUS, MRI and CT was compared using McNemar’s test with Bonferroni correction; kappa values were assessed for reader performance. Results 74 study participants (60 ± 8 yrs.; 56 men) with esophageal cancer were evaluated, of whom 85%(63/74) had squamous cell carcinoma, 61%(45/74) were at early stage and 39%(29/74) were at late stage cancer, as determined by histopathology. Intra- and Inter-reader agreement for pre-operative vs post-operative T-staging was excellent for all imaging modalities. Compared to CT, MRI showed significantly higher accuracy for both the readers (reader3: 96% vs 82%, p = 0.0038, reader4: 95% vs 80%, p = 0.0076, for MRI vs CT, respectively). Further, MRI outperformed EUS with higher specificity (reader 1 vs 3: 59% vs 93%, p = 0.0015, reader 2 vs 4: 66% vs 93%, p = 0.0081, for EUS vs MRI respectively), and accuracy (reader 1 vs 3: 81% vs 96%, p = 0.0022, reader 2 vs 4: 85% vs 95%, p = 0.057, for EUS vs MRI, respectively). Conclusion For resectable esophageal cancer, MRI had better diagnostic performance for tumor staging compared to CT and EUS. Trial registration ChiCTR, ChiCTR-DOD, Registered 2nd October 2014, http://www.chictr.org.cn/showproj.aspx?proj=9620

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Section: Discussionmentioning

confidence: 99%

A prospective analysis of the diagnostic accuracy of 3 T MRI, CT and endoscopic ultrasound for preoperative T staging of potentially resectable esophageal cancer

et al. 2020

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“…ESCC, a type of squamous epithelium differentiation of a malignant tumour within the oesophagus, accounts for the vast majority of oesophageal cancers [64, 65]. ESCC often presents in physiological or pathological stenosis of the oesophagus, and genetic factors, carcinogens, and/or chronic irritants may contribute to the pathogenesis of ESCC [64, 65]. The GSTP1 rs1695 A/G polymorphism is significantly related to the risk of ESCC in the Kashmiri population [42].…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

2019

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BackgroundThere are several meta-analyses on the genetic relationship between the rs1695 polymorphism within the GSTP1 (glutathione S-transferase pi 1) gene and the risk of different SCC (squamous cell carcinoma) diseases, such as ESCC (oesophageal SCC), HNSCC (head and neck SCC), LSCC (lung SCC), and SSCC (skin SCC). Nevertheless, no unified conclusions have been drawn.MethodsHerein, an updated meta-analysis was performed to evaluate the probable impact of GSTP1 rs1695 on the susceptibility to different SCC diseases under six genetic models (allele, carrier, homozygote, heterozygote, dominant, and recessive). Three online databases, namely, PubMed, WOS (Web of Science), and Embase (Excerpta Medica Database), were searched.ResultsInitially, we obtained a total of 497 articles. Based on our selection criteria, we eventually included 52 case-control studies (9763 cases/15,028 controls) from 47 eligible articles. As shown in the pooling analysis, there was no difference in the risk of overall SCC disease between cases and controls [allele, Pa (P value of association test) = 0.601; carrier, Pa = 0.587; homozygote, Pa = 0.689; heterozygote, Pa = 0.167; dominant, Pa = 0.289; dominant, Pa = 0.548]. Similar results were obtained after stratification by race (Asian/Caucasian), genotyping, control source, and disease type (ESCC/HNSCC/LSCC/SSCC) (all Pa > 0.05).ConclusionThe rs1695 polymorphism within the GSTP1 gene is not associated with the risk of overall SCC or a specific SCC type, including ESCC, HNSCC, LSCC, and SSCC.

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“…Core member of the NCECS Study Group: Xuan Liu,1 Qiaozhi Zhou,1 Yue Jiao,1 Ying Meng,1 Ye Zong,1 Qinggang Wang,1 Yinglin Niu,1 Hongmei Li,1 Li Yu,1 Haiying Zhao,1 Wenyan Li,1 Xun Yang,1 Li Zhang,1 Fandong Meng,1 Haiyi Hu,1 Yanhua Zhou,1 Shuxia Yu,2 Baohong Xu,3 Jianyu Hao,4 Aimin Wang,5 Zhen He,1 Chuntao Liu,1 Jian Wei,1 Yue Tian,1 Pei Zhang,1 Zhonglin Yu1…”

Section: Acknowledgmentsunclassified

“…1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, People’s Republic of China; 2Department of Gastroenterology, Daxing Hospital, Beijing 102600, People’s Republic of China; 3Department of Gastroenterology, Luhe Hospital, Beijing 101100, People’s Republic of China; 4Department of Gastroenterology, Beijing Chaoyang Hospital, Beijing 100020, People’s Republic of China; 5Department of Gastroenterology, The 252nd Hospital of PLA, Baoding 071000, People’s Republic of China.…”

Section: Acknowledgmentsmentioning

confidence: 99%

“…Due to deficiencies in the serous layer, ESCC is highly aggressive and easily invades neighboring tissues 4. Most ESCC patients are diagnosed at a late stage and have a very poor prognosis 5. Kumar et al reported that the overall 5-year survival of ESCC is only 9%, but with early detection and treatment, the survival rate increases significantly 6.…”

Section: Introductionmentioning

confidence: 99%

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A nomogram for endoscopic screening in a high esophageal squamous cell cancer risk area: results from a population-based study

Xing

Zhang

et al. 2019

CMAR

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BackgroundEndoscopy is the main approach used for esophageal squamous cell carcinoma (ESCC) screening, especially in high-risk areas. However, little consensus has been achieved in recent ESCC screening programs, and endoscopists have selected patients only by age and family history.Patients and methodsTo generate a proper strategy for selecting an eligible population for endoscopic screening based on demographic factors, lifestyle, and eating habits, a total of 7,830 residents in an area with a high risk of ESCC were recruited for this study. All participants underwent endoscopic examinations that were conducted by experienced endoscopists. Risk factors for ESCC and other lesions were selected by univariate and multivariate logistic regressions. A nomogram for the prediction of ESCC and premalignant lesions was constructed, which included information on age, sex, occupation, labor intensity, income, and mining exposure. Receiver operating characteristic (ROC) curve analysis was performed to present the predictive accuracy of the nomograms.ResultsThe area under the curve (95% CI) was 0.749 (0.711–0.788) for this nomogram. By applying this nomogram, we could exclude 60% (4704/7830) of patients before endoscopy screening and detect all ESCC cases as well as most esophageal lesions in the remaining population.ConclusionIn conclusion, we provided a ready-to-use preclinical tool with the potential to select eligible people with high risk of ESCC for endoscopy screening.

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Evaluation of preoperative staging for esophageal squamous cell carcinoma

Cited by 32 publications

References 42 publications

A prospective analysis of the diagnostic accuracy of 3 T MRI, CT and endoscopic ultrasound for preoperative T staging of potentially resectable esophageal cancer

A prospective analysis of the diagnostic accuracy of 3 T MRI, CT and endoscopic ultrasound for preoperative T staging of potentially resectable esophageal cancer

Glutathione S-transferase pi 1 variant and squamous cell carcinoma susceptibility: a meta-analysis of 52 case-control studies

A nomogram for endoscopic screening in a high esophageal squamous cell cancer risk area: results from a population-based study

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