Evaluation of PRF Efficiency in the Treatment of Infrabony Defects

Milutinovic, Jana; Поповска, Мирјана; Rusevska, Biljana; Nacevski, Milan; Anastasovski, Stefan; Ivanovska-Stojanoska, Marija

doi:10.2478/prilozi-2020-0025

Cited by 2 publications

(4 citation statements)

References 21 publications

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“…PPD reduction was reported in 19 studies with a total of 1090 defect site 5,7,13–29 . PRF alone or plus biomaterials (e.g., xenograft, hydroxyapatite, metformin, statins) showed a statistically significant PPD reduction compared to OFD (high evidence) ( p < 0.05), while PRF plus bioactive glass versus OFD showed a statistically insignificant PPD reduction (low evidence) ( p > 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…CAL gain was reported in 19 included studies with a total of 1090 sites 5,7,13–29 . PRF alone or plus biomaterials (e.g., xenograft, bioactive glass, hydroxyapatite, statins) showed a statistically significant CAL gain when compared to OFD (high to moderate evidence) ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…PPD reduction was reported in 19 studies with a total of 1090 defect site. 5,7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] PRF alone or plus biomaterials (e.g., xenograft, hydroxyapatite, metformin, statins) showed a statistically significant PPD E).…”

Section: Follow-up 9 Monthsmentioning

confidence: 99%

“…5,7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] PRF alone or plus biomaterials (e.g., xenograft, bioactive glass, hydroxyapatite, statins) showed a statistically significant CAL gain when compared to OFD (high to moderate evidence) (p < 0.05).…”

mentioning

confidence: 99%

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Network meta‐analysis of platelet‐rich fibrin in periodontal intrabony defects

Mashrah

et al. 2023

J Oral Pathology Medicine

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Objectives: To evaluate the effect of platelet-rich fibrin alone or in combination with different biomaterials for the treatment of periodontal intra-bony defect. Methods: Up to April 2022, Cochrane library, Medline, EMBASE, and Web of Science databases were searched for randomized clinical trials. The outcomes of interest were probing pocket depth reduction, clinical attachment level gain, bone gain, and bone defect depth reduction. Bayesian network meta-analysis with 95% credible intervals was calculated. Results: Thirty-eight studies with 1157 participants were included. Platelet-rich fibrin alone or platelet-rich fibrin +biomaterials showed a statistically significant difference when compared with open flap debridement (p < 0.05, low to high certainty evidence). Neither biomaterials alone nor platelet-rich fibrin +biomaterials showed a statistically significant difference when compared to platelet-rich fibrin alone (p > 0.05, very low to high certainty evidence). Platelet-rich fibrin +biomaterials showed insignificant differences as compared to biomaterials alone (p > 0.05, very low to high certainty evidence). Allograft +collagen membrane ranked the best in probing pocket depth reduction while platelet-rich fibrin +hydroxyapatite ranked the best in bone gain. Conclusion: It seems that (1) platelet-rich fibrin with/without biomaterials were more effective than open flap debridement. (2) Platelet-rich fibrin alone provides a comparable effect to biomaterials alone and platelet-rich fibrin +biomaterials. (3) Plateletrich fibrin +biomaterials provide a comparable effect to biomaterials alone. Although allograft +collagen membrane and platelet-rich fibrin +hydroxyapatite ranked the best in terms of probing pocket depth reduction and bone gain respectively, the difference between different regenerative therapies remains insignificant, and therefore, further studies are still needed to confirm these results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Follow-up 9 Monthsmentioning

confidence: 99%

mentioning

confidence: 99%

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Network meta‐analysis of platelet‐rich fibrin in periodontal intrabony defects

Mashrah

et al. 2023

J Oral Pathology Medicine

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Exploring the Effectiveness of Guided Tissue Regeneration Techniques in Periodontal Disease Treatment and Its Long-Term Effects on Patients

Imtiaz,

Sadiq,

Tasleem

et al. 2024

PJHS-Lahore

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Periodontal disease is a bacterial infection that affects gums, alveolar bone and periodontal ligaments. An innovative approach to treat such infections is guided tissue regeneration which helps in the regeneration of tissues which are lost by this disease. Objectives: To assess the appropriateness of guided tissue regeneration procedures in periodontal management and evaluate the clinical benefits for patients. Methods: An intensive review of literature was made using PubMed, Science Direct and Google Scholar, by considering articles published between 2020-2024. Some of the analysed works investigated the effectiveness of guided tissue regeneration techniques as compared to other traditional methods of periodontal treatment. The parameters that have been evaluated include tissue repair, decrease in periodontal pocketing, gain in clinical attachment, and the aesthetic crown height index. The studies have been sourced from America, Europe and Asia. Results: Results from the studies highlight the efficacy of guided tissue regeneration techniques in the tissue repair process. It significantly highlights the improvements in dental attachment levels, long-term periodontal health and pocket reduction. However, variation in patients and their specified underlying conditions remain. Conclusions: It was concluded that guided tissue regeneration appears to provide an effective line of treatment for periodontal disease with the prediction of long-term therapeutic outcomes. Further studies should be carried out to enhance the properties of guided tissue regeneration materials and application methods to obtain more consistent results.

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Evaluation of PRF Efficiency in the Treatment of Infrabony Defects

Cited by 2 publications

References 21 publications

Network meta‐analysis of platelet‐rich fibrin in periodontal intrabony defects

Network meta‐analysis of platelet‐rich fibrin in periodontal intrabony defects

Exploring the Effectiveness of Guided Tissue Regeneration Techniques in Periodontal Disease Treatment and Its Long-Term Effects on Patients

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