1991
DOI: 10.3109/00016489109138428
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Evaluation of Procedures to Reduce Fluid Flow in the Fistulized Guinea-pig Cochlea

Abstract: The rate of longitudinal flow of fluid in scala tympani (ST) has been quantified under a number of experimental conditions. The method used to measure flow involved using a tracer ion (trimethylphenylammonium: TMPA) as a volume flow marker. Movement of marked perilymph was monitored by ion-selective microelectrodes which were capable of detecting exceedingly low concentrations of TMPA. Our results show that when the cochlea is perforated at the apex, flow rates of 400-500 nl/min are induced in ST, compared to … Show more

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Cited by 18 publications
(4 citation statements)
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“…There is no evidence that CSF enters the ear in appreciable volume at any other sites, such as through the auditory nerve, even though a boundary between the nerve and perilymph is lacking (Tinling & Chole, 1994). In experiments where hydrostatic pressure of the cochlea was released by perforating the round window membrane, there was no basally-directed flow down scala tympani toward the site of perforation (Salt et al, 1991a), demonstrating the cochlear aqueduct is the predominant site of CSF entry. The displacement of perilymph by CSF has been a major cause of contamination of perilymph samples collected from the basal turn of scala tympani (Salt et al, 2003).…”
Section: Perilymph Endolymph and Tissues Of The Earmentioning
confidence: 99%
“…There is no evidence that CSF enters the ear in appreciable volume at any other sites, such as through the auditory nerve, even though a boundary between the nerve and perilymph is lacking (Tinling & Chole, 1994). In experiments where hydrostatic pressure of the cochlea was released by perforating the round window membrane, there was no basally-directed flow down scala tympani toward the site of perforation (Salt et al, 1991a), demonstrating the cochlear aqueduct is the predominant site of CSF entry. The displacement of perilymph by CSF has been a major cause of contamination of perilymph samples collected from the basal turn of scala tympani (Salt et al, 2003).…”
Section: Perilymph Endolymph and Tissues Of The Earmentioning
confidence: 99%
“…The perilymphatic flow rate has been shown to increase by about two orders of magnitude following an experimentally induced fistula. 21 Therefore, an increased perilymph flow as a result of the inoculation may increase the risk of viral spread into the middle ear. Perilymph leakage may be due to an incomplete seal at the injection site.…”
Section: This Region Represents the Opening Of The Cochlear Aqueduct mentioning
confidence: 99%
“…perilymph) in the scala tympani is very low [31], experimental measurements report flows in the range of 1.6 nL min −1 [32]. However, in a damaged cochlea, this can rise to 0.5 µLmin −1 [33]. The perilymph flow rate for an undamaged cochlea is too low to provide significant cooling and will have less influence on temperature achieved than blood flow (E ≈ 13 µJmin −1 ).…”
Section: Discussionmentioning
confidence: 99%