Evaluation of Proliferative Activity of Endometrial Metaplasias by Agnor Technology

Abstract

Endometrial metaplasia represents the transformation of glandular structures of the endometrium into other functionally and morphologically different tissue. The presence of endometrial metaplasia can be observed during other concomitant benign as well as malignant pathology. They can occur separately or with other histopathological changes. In the studied cases of endometrial metaplasia, the cases of immature squamous cell metaplasia are characterized by the maximum number of AgNOR staining and accordingly the maximum proliferative activity. In this group, the average number of AgNOR staining is 1.61 times higher than the mature squamous metaplasia and 2.44 times exceeds the average rate of ciliary metaplasia. Based on the above mentioned, additionally AgNOR staining is recommended to be used in routine diagnostic practice in cases of endometrial metaplasia as an additional method for evaluating proliferative activity.