Evaluation of Prooxidant–Antioxidant Balance in Chronic Heroin Users in a Single Assay: An Identification Criterion For Antioxidant Supplementation

Kovatsi, Leda; Njau, Samuel; Nikolaou, Konstantin; Topouridou, Konstantina; Papamitsou, Theodora; Koliakos, George

doi:10.3109/00952990.2010.495438

Cited by 13 publications

(4 citation statements)

References 29 publications

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“…Opium is traditionally smoked in Iran recreationally or as a remedy for pain, diarrhea and insomnia (2,3). Opiate abuse is related to oxidative stress that is evaluated separately through oxidants and antioxidants (4).…”

Section: Contextmentioning

confidence: 99%

Study of Oxidants and Antioxidants in Addicts

Karajibani

Montazerifar

Feizabad

2016

Int J High Risk Behav Addict

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Context: This study was a systematic review that aimed to extract published articles regarding oxidant and antioxidants status in opium addiction by searching in PubMed, Google Scholar engine, SID, and Magiran databases. Evidence Acquisition: Sixty-six published articles were investigated in this review, which were selected from studies among the Iranian society and other societies from 1976 to 2015. All articles published in different fields of descriptive-analytical, experimental, and interventional studies were considered. Results: Several studies have shown that with increased production of free radicals and reactive oxygen species (ROS), the enzymatic and non-enzymatic antioxidants such as glutathione (GSH) and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase activities, and also the concentration of vitamins A, E, C and total antioxidant capacity (TAC) decrease in opium addiction. Increased atherogenic indexes such as Low density lipoprotein/high density lipoprotein (LDL/HDL) ratio and malondialdehyde (MDA) may contribute to the increased risk of cardiovascular disease. However, it has also increased other markers of oxidative stress including: isoprostanes, 8-oxoguanine and protein carbonyl. Conclusions: Oxidative stress increases in opium-addicted people. It seems that opium is capable of provoking oxidative stress and also, has harmful effects on lipid profile and antioxidant enzyme. Drug addicts were found to have antioxidant vitamin deficiency.

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Section: Contextmentioning

confidence: 99%

Study of Oxidants and Antioxidants in Addicts

Karajibani

Montazerifar

Feizabad

2016

Int J High Risk Behav Addict

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“…30,31 Furthermore, drug abusers are at oxidative stress. 32,33 Interestingly, the mRNA expression levels of several anti-oxidant genes significantly decreased in SH-SY5Y cells treated with morphine. 34 It has been reported that oxidative stress plays an important role in drug dependency.…”

Section: Discussionmentioning

confidence: 98%

Expression levels of PDYN and OPRM1 genes in SH-SY5Y cells exposed to 50 Hz electromagnetic field

Mahmoudinasab¹,

Saadat²

2018

Pol Ann Med

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“…Accordingly, reports from several groups that levels of AT8 antibody, a biomarker of tau-P, are elevated in postmortem brain in illicit opioid users, even in users under age 30 (Ramage et al, 2005;Anthony et al, 2010;Kovacs et al, 2015;Flanagan et al, 2018), as are levels of APP (Ramage et al, 2005), suggest that individuals with opioid use disorder are at increased risk for developing AD/ADRD. Opioids increase oxidative stress in brain, blood, and body (Zhou et al, 2000;Qiusheng et al, 2005;Arana et al, 2006;Xu et al, 2006;Pereska et al, 2007;Pérez-Casanova et al, 2008;Doyle et al, 2009;Ndengele et al, 2009;Abdel-Zahar et al, 2010;Kovatsi et al, 2010aKovatsi et al, , 2010bCemek et al, 2011;Gutowicz et al, 2011;Sumathi et al, 2011;Deng et al, 2012;Ghazavi et al, 2013;Soykut et al, 2013;Fan et al, 2015;Motaghinejad et al, 2015;Samarghandian et al, 2015;Yun et al, 2015Yun et al, , 2017Lauro et al, 2016;Najafi et al, 2017;Mansouri et al, 2018) and thus could increase Aβ and tau-P syntheses and accumulations via multiple mechanisms described above. In neuronal culture, morphine upregulates GSK3β activity (Masvekar et al, 2015), which could contribute to increased tau-P levels in opioid users.…”

Section: Opioid Use Disordermentioning

confidence: 99%

Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?

Kaufman

Kanayama

Hudson

et al. 2019

Neuroscience & Biobehavioral Reviews

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Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with physiologic, cognitive, and brain abnormalities similar to those found in people at risk for developing Alzheimer's Disease and its related dementias (AD/ADRD), which are associated with high brain β-amyloid (Aβ) and hyperphosphorylated tau (tau-P) protein levels. Supraphysiologic-dose AAS induces androgen abnormalities and excess oxidative stress, which have been linked to increased and decreased expression or activity of proteins that synthesize and eliminate, respectively, Aβ and tau-P. Aβ and tau-P accumulation may begin soon after initiating supraphysiologic-dose AAS use, which typically occurs in the early 20s, and their accumulation may be accelerated by other psychoactive substance use, which is common among non-medical AAS users. Accordingly, the widespread use of supraphysiologic-dose AAS may increase the numbers of people who develop dementia. Early diagnosis and correction of sex-steroid level abnormalities and excess oxidative stress could attenuate risk for developing AD/ADRD in supraphysiologic-dose AAS users, in people with other substance use disorders, and in people with low sex-steroid levels or excess oxidative stress associated with aging.

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Evaluation of Prooxidant–Antioxidant Balance in Chronic Heroin Users in a Single Assay: An Identification Criterion For Antioxidant Supplementation

Abstract: Chronic heroin users can benefit from an antioxidant therapy, and the method currently presented can be used as an identification criterion.

Cited by 13 publications

References 29 publications

Study of Oxidants and Antioxidants in Addicts

Study of Oxidants and Antioxidants in Addicts

Expression levels of PDYN and OPRM1 genes in SH-SY5Y cells exposed to 50 Hz electromagnetic field

Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?

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