Evaluation of prophylactic effect of herbal formulation In streptozotocin and HFHF diet induced Diabetes and its complication

Dawane, Jayshree; Pandit, Vijaya; Khatavkar, Pallawi Shashank; Bhosale, Madhura Shirish Kumar

doi:10.22376/ijpbs.2017.8.4.p237-244

Cited by 1 publication

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“…5-(p-florobenzylidene)-3-(p-chlorophenyl)-1,2,4-triazine-6-one(2) and 5-(p-fiorobenzylidene)-3-(pchlorophenyl)-2(amino)thiocarbonyl-1,2,4-triazine-6-one(3) were prepared by the reaction of 1,3-oxazolinone(1) with nitrogen nuclophilic reagents (such as hydrazine hydrate and thiosemicarbazide) in different conditions under reflux (20) . Acylation of 1,2,4-tiazine-6-one(2) with acetic anhydride under reflux led to the formation of 5-(p-florobenzylidene)-…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and Biological Evaluation of New 1,2,3,5Tetrasubstituted-1,2,4-triazine-6-ones

Hasanen¹,

Ashour²,

Zkaria³

2017

IAM

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5-(P-Florobenzylidene ) -3-(P-Chlorophenyl )-2-substituted-1,2,4-triazine-6-ones ( 2 and 3 ) were prepared via cyclocondensation of 1,3-oxazolinon derivative (1) with hydrazine hydrate and thiosemicarbazide . Treatment of compound (3) with phenacyl bromide and P-hydroxyl benzalhyde yeilded the corresponding to 5-(pflorobenzylidene)-3-(p-chlorophenyl)-2-(5-phenyl-1,3-thiazol-2-yl) -1,2,4-triazine-6-one (5) and 5-(pfiorobenzylidene) -3-(p-chlorophenyl)-2(p-hydroxy benzylidene amino) thiocarbonyl-1,2,4-triazine-6-one(7). Acetylation of compound ( 2 ,5 and 7) with acetic anydriede led to the formation of monoacetyl and diacetyl derivatives ( 4 ,6 and 8 ) .The structure of synthesized compounds were established with IR ,NMR ,MS and elemental analysis. Some of the new 1,2,4-triazine derivatives were evaluated for cytotoxicity activities.

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Section: Chemistrymentioning

confidence: 99%