Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study

Alqahtani, Saad M; Nagate, Raghavendra Reddy; Al-Ahmari, Manae Musa Musleh; Magbol, Mohammad Al.; Gokhale, Shankar T.; Tikare, Shreyas; Chaturvedi, Saurabh

doi:10.3390/gels9060483

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…To achieve effective occlusion of DTs in DH treatment, hydrogels emerge as a promising solution, bypassing the need for additional chemical reactions and providing immediate DT occlusion. [ 19 ] For example, Curodon D'Senz gel, a commercial desensitizer based on a self‐assembling peptide matrix, effectively alleviates DH. [ 20–22 ] However, due to its limited liquidity, it struggles to enter DTs, resulting in surface occlusion prone to detachment after friction, leading to a risk of poor long‐term effect.…”

Section: Introductionmentioning

confidence: 99%

A Drop‐By‐Drop Self‐Assembled All‐Natural Hydrogel as a Desensitizer for Rapid and Enduring Management of Dentin Hypersensitivity

Gao,

Liu,

et al. 2024

Adv Healthcare Materials

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Dentin hypersensitivity (DH) is a prevalent dental condition arising from the exposure of dentin tubules (DTs), leading to discomfort upon external stimuli. However, achieving swift and profound occlusion of these exposed DTs for immediate and enduring relief remains challenging due to the intricate dentin structure and oral environment. Herein, we propose a pioneering and facile drop‐by‐drop strategy involving an in‐situ generated natural supramolecular hydrogel formed by self‐assembling silk fibroin (SF) and tannic acid (TA) within the narrow DT space. When SF and TA aqueous solutions are applied successively to exposed dentin, they penetrate deeply within DTs and co‐assemble into compact gels, robustly adhering to DT walls. This yields a rapid and compact occlusion effect with an unprecedented depth exceeding 250 μm, maintaining stable occlusion efficacy even under rigorous in vitro and in vivo erosion and friction conditions for no less than 21 d. Furthermore, the biocompatibility and effective occlusion properties are verified through cell studies in simulated oral settings and an in vivo rabbit model. This study, for the first time, demonstrates the translational potential of hydrogel‐based desensitizers in treating DH with prompt action, superior occlusion depth and enduring treatment benefits, holding promise as clinical‐friendly restorative solutions for delicate‐structured biosystems.This article is protected by copyright. All rights reserved

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Section: Introductionmentioning

confidence: 99%

A Drop‐By‐Drop Self‐Assembled All‐Natural Hydrogel as a Desensitizer for Rapid and Enduring Management of Dentin Hypersensitivity

Gao,

Liu,

et al. 2024

Adv Healthcare Materials

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In vitro study of the treatment of dentin hypersensitivity with gallic acid combined with sodium fluoride

Han,

Zheng,

Zhao

et al. 2024

BMC Oral Health

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Background Dentin hypersensitivity (DH) is a common oral condition that is associated with severe dental pain. Pain relief is a key focus of the treatment of DH. The purpose of this study was to evaluate the blocking and antacid effects of gallic acid (GA) combined with sodium fluoride (NaF) on dentinal tubules in vitro. Methods Ninety dentin discs from human third molars were treated with 6% citric acid for 2 min. Then, the surface morphologies of ten dentin discs were observed by scanning electron microscopy (SEM). The remaining samples were randomly divided into four groups: the NaF group, which was treated with 1000 ppm NaF; the GA group, which was treated with 4000 ppm GA; the GA + NaF group, which was treated with 1000 ppm NaF + 4000 ppm GA; and the blank group, which was treated with deionized water. The dentin permeability of each sample was measured with a water-filled system before processing and after 7 days of treatment. Dentin morphology and surface deposits were observed by SEM. Then, samples from the NaF, GA + NaF and blank groups were subjected to an acid challenge by incubation with 0.02% citric acid for 2 min. SEM and a water-filled system were used to evaluate the blocking and antacid effects of NaF and GA + NaF. Results 1. NaF and GA + NaF significantly decreased dentin permeability. The effect of the GA + NaF treatment was more significant. After acid challenge, both groups still exhibited decreased dentin permeability compared with the initial assessment. 2. Compared with the NaF group, the GA + NaF group had more mineral deposits on the dentin surface and dentin tubules. After acid challenge, the deposits in the GA + NaF group were still clearly visible. Conclusion The combined effect of GA and NaF on reducing dentin permeability by blocking open dentin tubules is better than that of NaF alone. After acid challenge, the GA + NaF treatment still had a better effect.

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Herbal Medicine as an Adjunct in the Treatment of Periodontal Diseases - A Systematic Review

Abu Tamam,

Kukreja,

Ramachandra

et al. 2024

TODENTJ

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Background In recent times, a shift has been observed among both researchers and dental patients towards opting for herbal remedies and products to address issues like dental caries, gingivitis, periodontitis, periimplantitis, and dentin hypersensitivity. These herbal solutions encompass herbs, herbal constituents, formulations, and products derived from genuine plant components or other plant-derived materials. Objective This study aims to provide a comprehensive overview of the current body of literature regarding the added advantages of herbal medicinal products in managing periodontal and peri-implant conditions. Methods RCT published in English from 2013 till Sep 2023 in the terms “medicinal plants,” “plant medicine,” “dental herbs,” “medical herbs,” and “phytomedicine” were utilized to identify pertinent research papers. These search phrases were applied across the databases of PubMed, Scopus, and Web of Science. Case reports, case series, longitudinal studies, and retrospective analyses were not included. PRISMA standards were followed in this review. Results A total of fifteen (n=24) randomized clinical trials about herbal drugs and periodontal implications and three (n=3) trials on dental hypersensitivity were assessed. The trials assessed the use of various herbal products in treating periodontal and per-implant conditions. Conclusion Plant-based phytochemicals have anti-inflammatory effects that could be used as an alternative to treat periodontal and peri-implant conditions. Recent research on the different active components included in this study show significant improvements in the clinical parameters. To suggest them as substitutes for the non-herbal elements, more research is necessary.

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Evaluation of Propolis Hydrogel for the Treatment of Dentinal Sensitivity: A Clinical Study

Cited by 3 publications

References 57 publications

A Drop‐By‐Drop Self‐Assembled All‐Natural Hydrogel as a Desensitizer for Rapid and Enduring Management of Dentin Hypersensitivity

A Drop‐By‐Drop Self‐Assembled All‐Natural Hydrogel as a Desensitizer for Rapid and Enduring Management of Dentin Hypersensitivity

In vitro study of the treatment of dentin hypersensitivity with gallic acid combined with sodium fluoride

Herbal Medicine as an Adjunct in the Treatment of Periodontal Diseases - A Systematic Review

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