Evaluation of Prostate-Specific Antigen in Untreated Prostatic Carcinoma

Effects of 3 Months' Neoadjuvant Hormonal Treatment with a GnRH Analogue (Triptorelin) prior to Radical Retropubic Prostatectomy on Prostate-Specific Antigen and Tumour Volume in Prostate Cancer

“…Prostate-specific antigen (PSA) has lately replaced prostatic acid phosphatase as the predominant tumour marker in prostate cancer (PC) [1], For all practical pur poses, PSA is exclusively produced by the prostatic epi thelial cells, both benign and most malignant cells [2], In benign conditions, the serum levels are usually low but a correlation between PSA and prostate volume has been found in patients with benign prostatic hyperplasia [3,4], Among patients with PC, the serum levels are usually higher. Also, in malignant disease there is a correlation between tumour burden and PSA, both in patients with whether PSA after hormonal treatment actually reflects the true tumour situation [10,11].…”

Prostate-Specific Antigen in the Follow-Up of Prostatic Adenocarcinoma Treated with External Beam Radiation

“…In monitoring responses and recurrences of prostatic cancer, PAP has not been clearly correlated to tumor volume [5]. Patients with ele vated levels of serum PAP at the time of diagnosis have a poorer prognosis than those, with similar stage of the disease, with normal serum PAP [5][6][7], PSA has been shown to be more sensitive than PAP in detecting pros tatic cancer [8][9][10][11]. PSA values have been shown to fall to an undetectable level after radical prostatectomy [5,12].…”

Influence of Prostatic Disease and Prostatic Manipulations on the Concentration of Prostate-Specific Antigen

“…How ever, all diseases of the prostate (e.g., BPH, PCA, inflam Ferro et al [6] found, in 33% of 40 BPH patients, PSA values > 10 ng/ml. Oosteroom et al [ 10] ascertained this…”

“…Some authors report on a linear correlation between serum PSA levels and BPH size [8,10,11], In PCA with increasing tumor size, a proportional increase in the PSA value has been described, too [15], Stamey et al [4] deter mined values of 0.29-0.31 ng/ml per gram of transurethrally resected prostatic tissue.…”

“…How ever, massively increased PSA values were found in meta static PCA only [3][4][5][9][10][11]. Therefore, in the follow-up of a patient treated for PCA, an increasing PSA value may give a first indication of progress [12,13].…”