Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. MILL.) against alloxan-induced diabetes in mice

Berraaouan, Ali; Ziyyat, Abderrahim; Mekhfi, Hassane; Legssyer, Abdelkhaleq; Aziz, Mohammed; Bnouham, Mohamed

doi:10.1016/j.apjtm.2015.06.013

Cited by 49 publications

(32 citation statements)

References 28 publications

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“…Among the action of the oil is the partial reduction of D‐glucose intestinal absorption. Successively, the same research group showed that the administration of the oil prevents alloxan‐induced diabetes by quenching the free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β‐cells . These activities could be ascribed to the chemical composition of the oil, since it demonstrated that linoleic acid and oleic acid are the primary abundant compounds.…”

Section: Resultsmentioning

confidence: 99%

Comparative Chemical Composition and Bioactivity of Opuntia ficus‐indica Sanguigna and Surfarina Seed Oils Obtained by Traditional and Ultrasound‐Assisted Extraction Procedures

Loizzo

Bruno²,

Balzano

et al. 2018

Euro J Lipid Sci & Tech

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This study investigates the seed oils obtained from two different varieties of Opuntia ficus‐indica (Sanguigna and Surfarina) growing in Sicily, Italy. Soxhlet and ultrasound‐assisted extraction procedures are used to obtain the seed oils. The fatty acid profile, γ‐tocopherols, carotenoid content, and the bioactivity in terms of the antioxidant effects (using ABTS, DPPH, FRAP, and β‐carotene bleaching tests), and carbohydrate‐hydrolysing enzyme inhibitory activity (α‐amylase and α‐glucosidase) are determined. The extraction procedure does not significantly affect the fatty acid composition of the oil, but it does affect the tocopherol and carotenoid contents, as well as the antioxidant and inhibitory activities. All the oil samples are rich in polyunsaturated fatty acids, especially linoleic, and oleic acids. Soxhlet extraction proves to be the best extraction procedure to enrich the oils in γ‐tocopherol. Relative antioxidant capacity index (RACI) and global antioxidant score (GAS) analyses are applied to evaluate the antioxidant potential of the Sanguigna variety oil extracted with the Soxhlet apparatus that is shown to be the most active. The same oil also shows the highest α‐amylase inhibitory activity (IC50 value of 40.9 μg mL−1), which is better than that reported for acarbose used as a positive control. Practical Applications: This study is the first to evaluate the effect of oil extraction technologies on the bioactive compound levels and antioxidant and hypoglycaemic activities of cactus pear seed oil, which is a by‐product of fruit processing. The findings will contribute to the valorization of food by‐products. The results provide useful information to select the most valuable technological conditions for oil extraction to preserve the bioactive compounds and the biological activity of the vegetable by‐product extracts, such as seed oil. Cactus pear seed oil obtained by the traditional extraction procedure (Soxhlet) represents a promising source of healthy compounds, particularly of carotenoids and γ‐tocopherol, used not only as antioxidants to preserve lipid components in food preparation but also as functional ingredients due to their hypoglycaemic effect. Effect of extraction procedure on chemical composition, antioxidant potential, and hypoglycaemic activity of cactus pear seed oils.

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Section: Resultsmentioning

confidence: 99%

Comparative Chemical Composition and Bioactivity of Opuntia ficus‐indica Sanguigna and Surfarina Seed Oils Obtained by Traditional and Ultrasound‐Assisted Extraction Procedures

Loizzo

Bruno²,

Balzano

et al. 2018

Euro J Lipid Sci & Tech

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“…Opuntia spp. may exert an inhibitory effect on the oxidative environment generated by hyperglycemia, via their antioxidant components, and as suggested by a recent report by Berraaouan et al [93] who showed that cactus pear seed oil from O. ficus-indica L. Mill. prevents the development of alloxan-induced diabetes in mice by quenching the generation of ROS.…”

Section: Biological and Medical Properties Of Opuntia Spp In Chromentioning

confidence: 89%

Opuntia spp.: Characterization and Benefits in Chronic Diseases

Díaz

Rosa

Héliès-Toussaint

et al. 2017

Oxidative Medicine and Cellular Longevity

112

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Opuntia species have been used for centuries as food resources and in traditional folk medicine for their nutritional properties and their benefit in chronic diseases, particularly diabetes, obesity, cardiovascular diseases, and cancer. These plants are largely distributed in America, Africa, and the Mediterranean basin. Opuntia spp. have great economic potential because they grow in arid and desert areas, and O. ficus-indica, the domesticated O. species, is used as a nutritional and pharmaceutical agent in various dietary and value-added products. Though differences in the phytochemical composition exist between wild and domesticated (O. ficus-indica) Opuntia spp., all Opuntia vegetatives (pear, roots, cladodes, seeds, and juice) exhibit beneficial properties mainly resulting from their high content in antioxidants (flavonoids, ascorbate), pigments (carotenoids, betalains), and phenolic acids. Other phytochemical components (biopeptides, soluble fibers) have been characterized and contribute to the medicinal properties of Opuntia spp. The biological properties of Opuntia spp. have been investigated on cellular and animal models and in clinical trials in humans, allowing characterization and clarification of the protective effect of Opuntia-enriched diets in chronic diseases. This review is an update on the phytochemical composition and biological properties of Opuntia spp. and their potential interest in medicine.

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“…prevent diabetes complications, and may even inhibit the disease's development . In mice, the OFI oil clearly shows protective effects against chemically induced (alloxan) diabetes mellitus . In detail, it acts by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β‐cells.…”

Section: Uses and Benefitsmentioning

confidence: 99%

Opuntia ficus‐indica seed oil: Biorefinery and bioeconomy aspects

Ciriminna

Delisi²,

Albanese

et al. 2017

Euro J Lipid Sci & Tech

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In this study, we offer a perspective written from a biorefinery viewpoint aimed at expanding the cactus peer seed oil market and utilizations. Besides antioxidant and skin and hair hydrating action which make it suitable as a valued cosmetic ingredient, the oil contained in the seeds of Opuntia ficus‐indica and Opuntia dillenii, rich in unsaturated fatty acids, also shows anti‐inflammatory properties which offer significant potential as functional ingredient of nutraceutical and food supplement products. Practical applications: The outcomes of the study will be useful in progressing the expansion of the emerging bioeconomy, especially in Opuntia producing countries. The oil contained in the seeds of prickly pear cactus is rich in unsaturated fatty acids and shows significant anti‐inflammatory properties which offer significant potential as functional ingredient of nutraceutical and food supplement products. We offer a perspective written from a biorefinery viewpoint aimed at expanding the utilization of this valued bio‐derived oil.

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Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. MILL.) against alloxan-induced diabetes in mice

Abstract: Based on theses results, CPSO can prevente alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells.

Cited by 49 publications

References 28 publications

Comparative Chemical Composition and Bioactivity of Opuntia ficus‐indica Sanguigna and Surfarina Seed Oils Obtained by Traditional and Ultrasound‐Assisted Extraction Procedures

Comparative Chemical Composition and Bioactivity of Opuntia ficus‐indica Sanguigna and Surfarina Seed Oils Obtained by Traditional and Ultrasound‐Assisted Extraction Procedures

Opuntia spp.: Characterization and Benefits in Chronic Diseases

Opuntia ficus‐indica seed oil: Biorefinery and bioeconomy aspects

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