Evaluation of protective effect of bee pollen against propoxur toxicity in rat

Eraslan, Gökhan; Kanbur, Murat; Silici, Sibel; Liman, Bilal Cem; Altınordulu, Şule; Sarıca, Zeynep Soyer

doi:10.1016/j.ecoenv.2008.06.008

Cited by 70 publications

(47 citation statements)

References 22 publications

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“…In previous studies, researchers observed that diabetes caused an increase in the serum levels of total cholesterol and triglyceride (23). Thus, increased parameters can be due to the effects of diabetes on the permeability of membranes of hepatic cells (24). Lycopene showed protective effects against furan and diabetes-induced changes in hepatic function tests.…”

Section: Discussionmentioning

confidence: 99%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

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Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan-and diabetes-induced toxicity in rat liver.

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Section: Discussionmentioning

confidence: 99%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

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“…The detoxifying activity of pollen and bee bread in phenomena such as occupational diseases, heavy metal contamination, industrial gases and dusts, and drugs (antirheumatic and anti-inflammatory preparations and antibiotics) should also be mentioned (Eraslan et al, 2009).…”

Section: Tab 3 Bioactive Compounds Of Beebreadmentioning

confidence: 99%

Chemical Composition and Biological Activities of Beebread – Review

Urcan¹,

Mărghitaș²,

Dezmirean³

et al. 2017

BUASVMCN-ASB

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Beebread is a product of the hive obtained from pollen collected by bees, to which they add honey,digestive enzymes and subsequently is stored in the combs. The bees transform the bee pollen in beebread by an anaerobic fermentation process.A proper hive management promotes beebread collection, aimed at marketing it for human consumption since it can be considered a valuable food supplement due to its content of a wide range of nutrients. Its value is given by the content in protein, amino acids, fatty acids, carbohydrates, mineral salts, polyphenols and flavonoids, which depends on the botanical source of bee pollen. The nutritional and functional composition of beebread is widely reported; nevertheless, few studies on transformation processes of the pollen to improve the availability of the compounds present in this product were found. Overall, beebread is a recent collected and consumed bee product and at this stage it can be used as a food supplement.

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“…The propolis mechanism of action against mercury toxicity is not fully known, but it is believed that it can increase the elimination of heavy metals from the tissues through its antioxidant activity and metal chelating ability (5,7,10,21). Due to the presence of flavonoids and phenolic compounds, which are powerful free radical scavengers, propolis protects the cell membrane from lipid peroxidation (12,21).…”

Section: Resultsmentioning

confidence: 99%

“…As a natural compound of a bee's derivate product, propolis is a common name for a complex of various plant exudates mixture that contains a broad spectrum of biologically active compounds collected by honey bees (10,12). It is mainly used in construction, adaptation and protection of bee hives (5,7). Bee pollen is composed of amino acids, proteins, lipids, carbohydrates, enzymes, phenolic compounds as well as vitamins (4,10).…”

mentioning

confidence: 99%

Influence of the administration of propolis and bee pollen preparation on the concentration of mercury in the muscles, kidneys and liver of white storks

Piedra¹,

Zienkiewicz²,

Khudhur³

et al. 2018

Medycyna Weterynaryjna

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A total of ninety white storks (Ciconia ciconia) of both sexes aged over one year of life and at a body weight between 2.8 – 4.15kg were subjects for observations. They were collected from the Warmia and Masuria region, and were rehabilitees of The Wild Birds Rehabilitation Center (Bukwald, Poland). The storks formed a group of birds that had wing damage like broken bones and were unable to fly. According to the severity of the case storks underwent three different kinds of treatment. Light cases of motion disability were submitted to wing or leg stabilization with adhesive bandages (treatment I), while middle and severe cases were additionally submitted to the administration of one (treatment II) or two capsules (treatment III) of propolis and pollen bee preparation (Apipol Farma’s Propolis Plus®) for two weeks, respectively. After the convalescence period a total of twenty three white storks did not recover and were euthanized and dissected. Post mortem samples of pectoral and femoral muscles as well as liver and kidney samples were taken. Mercury concentration was analyzed and the results revealed that the level in the kidneys and liver of white storks not receiving propolis preparation were significantly higher than that of those from treatment II and III. Contrary to this, the mercury concentration recorded in the pectoral and femoral muscles of the birds of treatment II and treatment III were significantly higher than that of the treatment without propolis preparation. The results showed that propolis and pollen bee preparation can reduce the level of mercury in kidneys and liver, but has no influence on the reduction of mercury in pectoral and femoral muscles. .

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Evaluation of protective effect of bee pollen against propoxur toxicity in rat

Cited by 70 publications

References 22 publications

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Chemical Composition and Biological Activities of Beebread – Review

Influence of the administration of propolis and bee pollen preparation on the concentration of mercury in the muscles, kidneys and liver of white storks

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