Evaluation of proteinuria and GFR to diagnose and classify kidney disease: Systematic review and proof of concept

Regeniter, Axel; Freidank, Heike; Dickenmann, Michael; Boesken, W. H.; Siede, W

doi:10.1016/j.ejim.2009.03.006

Cited by 19 publications

(20 citation statements)

References 19 publications

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“…This highlights the need for more randomized clinical trials, not only in adults but especially in pediatric patients . A great advantage of these novel KI biomarkers is the possibility to identify the specific location of KI (Table ) …”

Section: Overview Of Kidney Injury Biomarkers For Detecting Drug‐relamentioning

confidence: 99%

“…1,2 A great advantage of these novel KI biomarkers is the possibility to identify the specific location of KI (Table 1). [3][4][5][6][7][8] In the pediatric population, validated adequate KI biomarkers to early and easily detect KI are lacking in clinical practice. Therefore, biomarker research for the optimized monitoring of the kidney function in neonates, infants, children, and adolescents remains an ongoing challenge.…”

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confidence: 99%

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Age‐Dependent Changes of Kidney Injury Biomarkers in Pediatrics

Donge

Welzel

Atkinson

et al. 2019

The Journal of Clinical Pharma

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Currently used creatinine‐based parameters for monitoring kidney function are not reliable for early detection of kidney injury (KI), particularly tubular damage. Several KI biomarkers allow for early detection of glomerular and tubular damage and may help to prevent drug‐related chronic kidney diseases in pediatrics. This literature review describes the state of current research and investigates reference values for these KI biomarkers in neonates, infants, and children to better understand age‐related changes. A total of 12 of 237 screened studies fulfilled predefined criteria, including 219 preterm neonates, 70 neonates, 596 infants, and 1726 children. KI biomarkers were analyzed in urine (6 studies), in serum/plasma (5 studies) and in serum and urine (1 study). Four studies (n = 555) measured urinary kidney injury molecule‐1, whereas urinary neutrophil gelatinase‐associated lipocalin was assessed in 5 studies (n = 888), and 2 studies (n = 203) investigated serum cystatin C. This review of KI biomarkers in different pediatric age groups indicates that (1) the majority of KI biomarkers are measured in urine; (2) the 3 most commonly analyzed KI biomarkers are urinary neutrophil gelatinase‐associated lipocalin, urinary kidney injury molecule‐1, and serum cystatin C; (3) values of KI biomarkers appear to decrease from prematurity to infancy; and (4) there is an unmet need to further enhance knowledge on age‐dependent changes of KI biomarkers in pediatrics. Studies are needed to better characterize reference values for these key KI biomarkers in healthy pediatric populations and to evaluate the value of these markers in the early detection of drug‐related KI in neonates, infants, and children.

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Section: Overview Of Kidney Injury Biomarkers For Detecting Drug‐relamentioning

confidence: 99%

mentioning

confidence: 99%

Age‐Dependent Changes of Kidney Injury Biomarkers in Pediatrics

Donge

Welzel

Atkinson

et al. 2019

The Journal of Clinical Pharma

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“…La American Diabetes Association y la National Kidney Foundation 3 recomiendan valorar la presencia de proteinuria o de albuminuria para detectar la enfermedad renal crónica . Una gran variedad de individuos tiene un elevado riesgo de presentar enfermedad renal crónica, entre ellos, los pacientes de edad avanzada, historia familiar de enfermedad renal crónica, hipertensión arterial, diabetes mellitus, enfermedades cardiovasculares, reducción de la masa renal, bajo peso al nacer, 4 enfermedades autoinmunes y sistémicas, uso de fármacos nefrotóxicos, entre otros .…”

Section: -unclassified

“…La excreción de cantidades elevadas de albúmina es un marcador sensible de enfermedad renal por diabetes mellitus e hipertensión arterial, también es un marcador de riesgo cardiovascular elevado en este tipo de 4 pacientes y en la población general .…”

Section: Evaluación De La Proteinuriaunclassified

“…La American Diabetes Association y la National Kidney Foundation recomiendan valorar la presencia de proteinuria (albuminuria severa) o albuminuria moderada (microalbuminuria) para detectar la enfermedad renal crónica. En muchas ocasiones no será necesario recoger orina de 24 horas para cuantificar la excreción de proteínas, siendo 4 suficiente la determinación del cociente ya citado .…”

Section: Evaluación De La Proteinuriaunclassified

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Correlación entre el cociente proteinuria/creatininuria en una orina al azar y la proteinuria de 24 horas

Cascán

Taboada

2015

Rev. virtual Soc. Parag. Med. Int

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Correlación entre el cociente proteinuria/creatininuria en una orina al azar y la proteinuria de 24 horas Correlation between the random urine protein-creatinine ratio and 24-hour proteinuria Artículo recibido: 3 enero 2015 Artículo aceptado: 26 enero 2015 ResumenIntroducción: la cuantificación de proteínas en orina es un estudio que evalúa la afectación renal por ciertas enfermedades. Su medición puede realizarse también a través del cociente proteinuria/creatininuria. Objetivo: determinar la correlación entre el cociente proteinuria/creatininuria y la proteinuria de 24 horas. Metodología: se realizó un estudio descriptivo observacional, prospectivo con componente analítico de corte transverso, de muestreo no probabilístico. Se incluyó a 60 pacientes con factores de riesgo de padecer enfermedad renal crónica, que acudieron al Hospital Nacional (Itauguá) en el año 2014. Todos se realizaron análisis de orina de 24 horas y de una muestra de orina al azar para estimar el cociente proteinuria/creatininuria. Resultados: se observó que existe una correlación muy significativa (r= 0,9 p < 0,001) entre los valores del cociente de proteinuria/creatininuria en una orina al azar y la proteinuria de 24 horas, con una sensibilidad 94,1% (IC95% 79-100), especificidad 100% (IC95% 98-100%), valor predictivo positivo 100% (IC95% 96-100) y valor predictivo negativo 97,7% (IC95% 92-100). Conclusiones: el cociente proteinuria/creatininuria es útil para detectar proteinuria en rango no nefrótico.Palabras claves: proteinuria, proteinuria de 24 horas, cociente proteinuria/creatininuria, hipertensión arterial, lupus eritematoso sistémicoCorr. entre el cociente prot./creat. en una orina al azar y la proteinuria de 24 hs. AbstractRev. virtual Soc. Parag. Med. Int. marzo 2015; 2 (1):74-92Introduction: The quantification of proteins in urine is a study that evaluates kidney involvement in some diseases. The measurement can be made through the urine protein-creatinine ratio. Objective: To determine the correlation between the urine protein-creatinine ratio and 24-hour urine protein. Methodology:A cross-sectional prospective observational descriptive study with analytical component and non-probabilistic sampling was performed. Sixty patients who had risk factors of chronic renal disease and attended the National Hospital (Itauguá) in 2014 were included. Twenty four-hour urine and a random urine sample were analyzed to estimate the protein-creatinine ratio. Results: A very significant correlation (r= 0.9 p < 0.001) was observed between the values of the proteincreatinine ratio in a random urine and 24-hour urine protein with a sensitivity of 94.1% (IC95% 79-100), specificity of 100% (IC95% 98-100%), positive predictive value of 100% (IC95% 96-100) and negative predictive value of 97.7% (IC95% 92-100). Conclusion:The protein-creatinine ratio is useful to detect proteinuria in a non-nephrotic range.Keywords: proteinuria, 24-hour proteinuria, urine protein-creatinine ratio, arterial hypertension, systemic lupus erythematosus IntroducciónLa enfe...

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Communicating Complex Results of Cerebrospinal Fluid Analysis

Regeniter¹,

Siede²

2021

Neuromethods

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Evaluation of proteinuria and GFR to diagnose and classify kidney disease: Systematic review and proof of concept

Cited by 19 publications

References 19 publications

Age‐Dependent Changes of Kidney Injury Biomarkers in Pediatrics

Age‐Dependent Changes of Kidney Injury Biomarkers in Pediatrics

Correlación entre el cociente proteinuria/creatininuria en una orina al azar y la proteinuria de 24 horas

Communicating Complex Results of Cerebrospinal Fluid Analysis

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