Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

Zhang, Yongtai; Shen, Lina; Zhao, Jihui

doi:10.2147/ijn.s57314

Cited by 86 publications

(27 citation statements)

References 34 publications

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“…14 Ethosomes are a novel type of liposomes containing a high concentration of shortchain alcohols, including ethanol, propylene glycol, or even a mixture of ethanol and propylene glycol. [15][16][17] The addition of ethanol improves the deformability of vesicles, thus overcoming some of the disadvantages of the conventional liposomes, but also carries the risk of skin irritation.…”

Section: Introductionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.

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Section: Introductionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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“…The in vitro RL was 35 ± 2 %, and it was similar to the RR in vitro, which indicated that PAB transport across probe membrane from the perfusate into the surrounding tissue was equal to that from the tissue into the perfusate. Therefore, the in vivo RL by retrodialysis was taken as the in vivo RR (Zhang et al, 2014). The in vivo RL was 34 ± 1 %, and it was also independent of the perfusate concentration, validating that the in vivo RR could be used to calibrate the PAB concentration in the skin.…”

Section: Dermal Pharmacokinetics Studiesmentioning

confidence: 91%

Microemulsion based gel for topical dermal delivery of pseudolaric acid B: In vitro and in vivo evaluation

Wan

Pan

et al. 2015

International Journal of Pharmaceutics

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“…In vivo skin microdialysis study showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3 and 2 times higher than those of psoralen from the tincture formulation indicating potential of ethosomal psoralen for improved treatment of vitiligo [92].…”

Section: Deformable (Elastic) Liposomesmentioning

confidence: 98%

(Phospho)lipid-based Nanosystems for Skin Administration

Vanić¹,

Holæter²,

Škalko‐Basnet

2015

CPD

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Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products

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Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

Cited by 86 publications

References 34 publications

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Microemulsion based gel for topical dermal delivery of pseudolaric acid B: In vitro and in vivo evaluation

(Phospho)lipid-based Nanosystems for Skin Administration

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