Evaluation of psychoemotional status of rats after brain injury and systemic transplantation of mesenchymal stem cells

Abstract

We studied the effects of systemic transplantation of mesenchymal stem cells obtained after culturing of autologous bone marrow on psychophysiological status of Wistar rats after diffuse brain trauma. Two months after systemic injection of mesenchymal stem cells we observed a decrease in manifestations of emotional behavioral reactions (anxiety and excitability) and shortening of the time of realization of drinking behavior in a T-maze. A significant positive effect of systemic transfusion of mesenchymal stem cells on avoidance conditioning in a shuttle box was observed 3 months after brain injury.

Bone marrow mesenchymal stem cell transplantation in acute brain trauma

“…A previous study suggested that MSCs increase production of nerve growth factor and brain-derived neurotrophic factor (BDNF) and induce repair of the central nervous system (4). The results of preclinical studies have suggested the usefulness of MSCs in TBI (32,33), but imaging methods have shown little evidence of a therapeutic effect.…”