Evaluation of pulse pressure variation and pleth variability index to predict fluid responsiveness in mechanically ventilated isoflurane‐anesthetized dogs

Sano, Hiroki; Seo, Joonbum; Wightman, Paul; Cave, Nick; Gieseg, Mike A.; Johnson, Craig B.; Chambers, Paul

doi:10.1111/vec.12728

Cited by 29 publications

(44 citation statements)

References 61 publications

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“…Out of 24 fluid challenges, 14 responders and 10 non‐responders were obtained as previously described . Heart rate did not change after the mini‐fluid challenges but heart rate in responders significantly increased after the fluid challenge (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…There were few studies to assess the fluid responsiveness using dynamic parameters based on heart–lung interactions during positive ventilation in dogs. Our previous study showed that more than 11% (sensitivity: 79%, specificity: 80%) of pulse pressure variation and more than 9.3% (sensitivity: 86%, specificity: 70%) of pleth variability index could predict fluid responders in mechanically ventilated isoflurane‐anesthetized dogs prior to a 10 mL/kg of fluid challenge . The other study revealed that either more than 4 mmHg or 4.5% of systolic pressure variation could predict fluid responsiveness in mechanically ventilated anesthetized dogs prior to a 3 mL/kg of crystalloids .…”

Section: Discussionmentioning

confidence: 99%

“…This study had several major limitations described in our previous report . First, the 24 individual anesthetics were not truly independent, but 2 fluid challenge studies were performed in each dog, in which they responded the same way or changed their responsiveness depending on their hemodynamic and hydration condition at the time of anesthesia.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously described the protocol approved by the animal ethics committee of Massey University (Protocol ID: 14/113) for anesthetizing the dogs, and measuring hemodynamic variables in response to a fluid challenge . The study described here was conducted concurrently using the same fluid challenge.…”

Section: Methodsmentioning

confidence: 99%

“…The end‐tidal isoflurane concentration and partial pressure of end‐tidal carbon dioxide were measured by a commercial monitor . Velocity time integral (VTI) of main pulmonary arterial flow was determined using transthoracic echocardiography by the same ultrasound expert, and fractional change in VTI (VTI%Δ) was calculated from VTI before and after fluid administration as an indication of percentage change in SV (SV%Δ) described by previous studies . Minor changes in transducer position did not influence Doppler frequency shift integral substantially in dogs …”

Section: Methodsmentioning

confidence: 99%

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Investigation of percentage changes in pulse wave transit time induced by mini‐fluid challenges to predict fluid responsiveness in ventilated dogs

Sano

Fujiyama

Wightman

et al. 2019

J Vet Emergen Crit Care

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Objective To investigate whether percentage changes in pulse wave transit time (PWTT%Δ) induced by mini‐fluid challenges predict fluid responsiveness in mechanically ventilated anesthetized dogs. Design Prospective experimental trial. Setting University teaching hospital. Animals Twelve Harrier hounds. Intervention Each dog was anesthetized with propofol and isoflurane after premedication with acepromazine, mechanically ventilated, and had a fluid challenge. This was repeated 4 weeks later. The fluid challenge, 10 mL/kg of colloid administration over 13 minutes, consisted of 3 intermittent mini‐fluid challenges (1 mL/kg of each over a minute) with a minute interval, and the remaining colloid administration (7 mL/kg) over 7 minutes. Measurements and Main Results Percentage change in velocity time integral of pulmonary arterial flow by echocardiography was calculated as an indication of change in stroke volume. Fluid responsiveness was defined as percentage change in velocity time integral ≥ 15% after 10 mL/kg colloid. Dogs responded on 14 fluid challenges and did not on 10. After 1, 2, 3, and 10 mL/kg of fluid challenge, PWTT%Δ1, 2, 3, 10 were measured. Receiver operator characteristic (ROC) curves were generated and areas under ROC curve were calculated for PWTT%Δ1, 2, 3. A gray zone approach was used to identify the clinically inconclusive range. The area under the ROC curve for PWTT%Δ3 was 0.91 (P = 0.001). Cutoff value for PWTT%Δ3 was −2.5% (sensitivity: 86%, specificity: 90%). The gray zone for PWTT%Δ3 was identified as between −2.9% to −1.9% for which fluid responsiveness could not be predicted reliably in 6 out of 24 fluid challenges. Conclusions In mechanically ventilated anesthetized dogs given a mini‐fluid challenge of 3 mL/kg of colloid, PWTT%Δ could predict fluid responsiveness although the gray zone should be considered.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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