Evaluation of radiation attenuation properties on a various composition of polydimethylsiloxane (PDMS) for fabrication of kidney phantom

Mechanical and Imaging Properties of a Clinical-Grade Kidney Phantom Based on Polydimethylsiloxane and Elastomer

“…The effective atomic number was constant in the intermediateenergy region, whereas noticeable variation was observed for low (<20 keV), as well as high-energy regions. Overall, the PDMS Z eff ranged around 4.00 to 5.00 in a higher energy range ≥ 1.00 × 10 −1 MeV and was comparable with the previous work [19]. This Z eff was lower at the intermediate energy range due to the dominance pair production and scattering effects.…”

“…In this study, we evaluated the tissue equivalence of the phantom by using a web-based software, Phy-X/PSD (Ataturk University, Erzurum, TR). The software is a web-based simulator that has a user friendly GUI interface, used to calculate Z eff in the energy region of 1 keV-20 MeV for photons (both photon interactions and photon energy absorption) and in the energy region of 1 MeV-1 GeV for electrons, protons, alpha particles, and ions [18,19]. The tissue equivalence of the tissue substitutes is represented by this method for the computation of effective atomic numbers in this study.…”

Radiotherapy on-chip: microfluidics for translational radiation oncology

“…41,42 Specifically, the characterization of the response of PDMS blends to various types of radiation exposure (including gamma radiation) demonstrated both their stability and water equivalence (ρ = 0.97 g cc −1 ). [43][44][45][46][47][48][49][50] This latter property specifies that PDMS density is very close to that of water (within 3%), ensuring that radiation interacts with PDMS like with water, physiological fluids and tissues on which dose-planning software are based. As such, the material can be easily modeled with standard clinical treatment planning software and is highly suitable for dosimetric planning and delivery at therapeutic dose-levels.…”

“…2B and C). [44][45][46][47][48][49] Similarly, microfluidic devices can easily be incorporated into clinically relevant experimental setups, such as treatment table supports (Fig. 2B-D).…”

Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology

“…Indeed, the radiological properties of PDMS are close enough to that of water or human tissue to ensure that radiation interacts with it in a similar fashion, thus greatly simplifying dose calculations and treatment planning. [37][38][39][40] In addition, the BT-on-chip can easily be sterilized, its layers peeled apart or cut, making it compatible with cell culture and posttreatment bioanalysis protocols. As the name indicates, the "wells" layer is comprised of 15 hexagonal wells designed for the formation and culture of hypoxic spheroids, following the principles defined by Refet-Mollof et al (Fig.…”