Evaluation of Rapid stool antigen test for the diagnosis of Helicobacter pylori infection in patients with dyspepsia

Khatun, Salma; Rahman, Fahmida; Shadia, Khandaker; Dutta, Indrajit Kumar; Hoq, Mohammad Nazmul; Akter, Farjana; Haq, Jalaluddin Ashraful

doi:10.3329/imcjms.v10i2.31108

Cited by 2 publications

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“…It was 14.2% in African rural children [28]. Positive H. pylori stool antigen means active infection or individual is harboring the organism whereas positive H. pylori IgG antibodies represent current or previous H. pylori infection [29]. In our study, the H. pylori infection rate by serum anti-H. pylori IgG antibodies was 64.9% while the H. pylori stool antigen positivity rate was 24.9%.…”

Section: Discussionmentioning

confidence: 50%

Asymptomatic Helicobacter pylori infection among rural children and adolescents in Bangladesh

Mazumder

Rahman

Akter

et al. 2022

IMC Journal of Medical Science

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Background and objectives: The Helicobacter pylori infection rate varies according to the age, location of the residence and socioeconomic status. The aim of the present study was to investigate the status of H. pylori infection among the asymptomatic Bangladeshi rural children and adolescents. Material and methods: This cross-sectional study was carried out in a rural area under Pabna district about 150 km north-west of capital Dhaka. Asymptomatic and apparently healthy rural children and adolescents aged 6 to 18 years were enrolled in the study. A structured questionnaire was used to record the socio-demographic and clinical information. The rate of H. pylori infection was determined by the presence of H. pylori antigen in faeces and/or anti-H. pylori IgG and/or IgA antibodies in blood. H. pylori stool antigen was detected by lateral flow chromatographic immunoassay and serum anti-H. pylori IgG and IgA antibodies were estimated by ELISA method. Results: A total number of 185 asymptomatic and apparently healthy children and adolescents were enrolled of which 34, 131 and 20 were in 6-10, 11-15 and 16-18 years age groups respectively. The overall H. pylori infection rate was 79.5% (95% CI: 0.729, 0.85) by positive stool antigen or by the presence of serum anti-H. pylori IgG/IgA antibodies. The rate of H. pylori infection significantly (p=0.05) increased with progress of age. H. pylori infection rate was 67.6%, 80.2% and 95% in 6-10, 11-15 and 16-18 years age groups respectively. The concentration of serum anti-H. pylori IgG/IgA antibodies did not differ across the age groups. The infection rate was significantly (p<0.05) higher among the children of illiterate parents compared to the children of literate parents. Conclusion: The study demonstrated a high prevalence of H. pylori infection among children and adolescents in a rural setting. Gender and family history did not affect H. pylori prevalence but increasing age and poor educational status of parents were associated with a higher H. pylori prevalence. IMC J Med Sci 2022; 16(2): 007. DOI: https://doi.org/10.55010/imcjms.16.017 *Correspondence: J. Ashraful Haq, Department of Microbiology, Ibrahim Medical College, 1/A, Ibrahim Sarani, Segunbagicha, Dhaka 1000, Bangladesh. Email: jahaq54@yahoo.com

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Section: Discussionmentioning

confidence: 50%

Asymptomatic Helicobacter pylori infection among rural children and adolescents in Bangladesh

Mazumder

Rahman

Akter

et al. 2022

IMC Journal of Medical Science

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“…In our previous study, we found that 83.5% of dyspeptic cases were positive for H. pylori infection either by stool antigen or serum anti-H. pylori IgA [11]. In the present study, we attempted to find out the anti-CagA IgG status in dyspeptic patients.…”

Section: Discussionmentioning

confidence: 87%

Helicobacter pylori CagA seropositivity in adult Bangladeshi patients with peptic ulcer and erosion

Rahman¹,

Shadia²,

Khatun³

et al. 2020

IMC J Med Sci

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Background: CagA IgG antibody in sera might indicate presence of virulent Helicobacter pylori in patients with peptic ulcer disease. Present study was performed to find out the prevalence of CagA IgG antibody in patients with peptic ulcer/erosion. Methods: Any case that had peptic ulcer/erosion, plus positive for rapid urease test (RUT) or H. pylori stool antigen (HpSAg) or serum anti-H. pylori IgG/IgA were included in the study and named as H. pylori positive case. H. pylori positive cases were tested for CagA IgG antibody. Anti-H. pylori IgG, IgA and CagA IgG antibodies were determined by enzyme-linked immunosorbent assay (ELISA) and stool antigen by rapid immunochromatographic test (ICT). Urease production in biopsy sample was detected by RUT. Results: Total 86 H. pylori positive patients were included in the study. Out of 86 patients, CagA IgG was positive in 34 (39.5%; 95% CI: 0.30,0.50) cases. CagA seropositivity rate in ulcer and erosion cases were 58.8% (95% CI: 0.36,0.78) and 34.8% (95% CI: 0.25,0.47) respectively. H. pylori stool antigen and IgA antibodies were positive in all (100%) CagA antibody positive ulcer cases while the rates were significantly less among the CagA antibody negative cases (42.8% and 28.6%; p<0.05). However, in CagA antibody positive erosion cases, the rates were not significantly different from CagA antibody negative cases. Conclusion: The study has demonstrated that the CagA positive strain is less prevalent in erosion than ulcer cases. Ibrahim Med. Coll. J. 2020; 14(1): 36-40

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Evaluation of Rapid stool antigen test for the diagnosis of Helicobacter pylori infection in patients with dyspepsia

Cited by 2 publications

References 13 publications

Asymptomatic Helicobacter pylori infection among rural children and adolescents in Bangladesh

Asymptomatic Helicobacter pylori infection among rural children and adolescents in Bangladesh

Helicobacter pylori CagA seropositivity in adult Bangladeshi patients with peptic ulcer and erosion

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