Evaluation of redox mediators for amperometric biosensors: Ru-complex modified carbon-paste/enzyme electrodes

Иванова, Э. В.; Sergeeva, Viktorya S.; Oni, Joshua; Kurzawa, Christian; Ryabov, Alexander D.; Schuhmann, Wolfgang

doi:10.1016/s1567-5394(03)00046-x

Cited by 46 publications

(28 citation statements)

References 18 publications

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“…The second scan voltammograms indicate the reduction peaks to be of reversible nature. On the basis of redox peaks at a potential very close to 0.0 V, the oxidation products of DTU and DPTU can be used as redox probes for the designing of electrochemical biosensors, 17,18 characterization of lyotropic liquid crystalline phases 19 and for the investigation of interactions between molecules/ions. 20,21 Cyclic voltammograms of 1 mM solutions of DTU and DPTU shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Spectroscopic Characterization and pH Dependent Electrochemical Fate of Two Non-Ionic Surfactants

Munir

Ullah

Shah

et al. 2014

J. Electrochem. Soc.

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Two new nonionic surfactants; 1-sec-butyl-3-dodecanoylthiourea (DTU) and 1-dodecanoyl-3-phenylthiourea (DPTU) were synthesized and characterized by 1 H NMR, 13 C NMR and FTIR and UV-Vis spectroscopy. The detailed electrochemical fate of DTU and DPTU was investigated in a wide pH range of 2-12 by employing three electroanalytical techniques. The voltammetric signatures of the analytes showed a single irreversible anodic peak followed by two reversible peaks of the oxidation product. The irreversible behavior of the oxidation process was witnessed by the unequal components of total current in square wave voltammetry and scan rate based deviation of peak potential. The involvement of protons accompanying the electron transfer processes was ascertained from peak potential versus pH plots. Critical micelle concentration and hydrophilic-lipophilic balance of the synthesized surfactants were determined for the assessment of their cleaning, wetting and emulsifying properties. Some detergents and surfactants have been restricted and prohibited in the developed countries due to adverse environmental consequences. The manufacturers are now trying to synthesize environmentally friendly surfactants according to the environmental protection laws.1,2 With these facts in mind, we synthesized thiourea based surfactants which are expected to increase the fertility of the soil if their washed water is directed toward agricultural fields.Surfactants are classified as ionics, nonionics and zwitter-ionics. The demand and consumption of ionic surfactants were greater than nonionics in the mid of 19 century but now the market share of nonionic surfactants has reached to 40% of the total worldwide surfactants production. Nonionic surfactants excel other types due to their neutral behavior, compatibility with ionic surfactants and capability of forming complex mixtures as found in many commercial products. 3,4 Nonionic surfactants are used as excellent solubilizing agents due to their very low critical micelle concentration. 5,6 Such surfactants can work even in hard water as they do not yield ions in aqueous solution and hence, less or almost insensitive to electrolytes. Due to their neutral behavior, nonionic surfactants are none or less toxic than ionic surfactants and hence find use in cosmetics, pharmaceuticals and food products.7-9 They can also be used as wetting agents, emulsifiers and detergents.10,11 Nowadays nonionic surfactants are in constant use in different varieties of domestic and industrial products. 12,13 Prompted by the peculiar characteristics of non-ionic surfactants such as very low critical micelle concentration, insensitivity to hard water, no or low toxicity, low cost and compatibility with ionic surfactants, we synthesized and spectroscopically characterized more effective candidates of this class in high yield using the protocol reported in our recent article.14 Moreover, the oxygen, nitrogen and sulfur donor atoms of thiourea derivatives provide a multitude of bonding possibilities. 15 Hence, the excellent me...

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Section: Resultsmentioning

confidence: 99%

Synthesis, Spectroscopic Characterization and pH Dependent Electrochemical Fate of Two Non-Ionic Surfactants

Munir

Ullah

Shah

et al. 2014

J. Electrochem. Soc.

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“…[1][2][3][4][5] Among the materials that may be used in conjunction with carbon paste are the ruthenium-containing compounds such as oxides, mixed valence compounds and complexes. These Ru-based materials possess electrocatalytic properties, which have been used to modify electrodes for electroanalysis of ascorbic acid, 6,7 L-dopa, 8 glucose, 9 benzylic compounds 10 and dopamine. 11 Dopamine (DA) and ascorbic acid (AA), in particular, are relevant from the biomedical and neurochemical point of view, for their importance to human metabolism.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous voltammetric determination of dopamine and ascorbic acid using multivariate calibration methodology performed on a carbon paste electrode modified by a mer-[RuCl3(dppb)(4-pic)] complex

Santos¹,

Sandrino²,

Moreira³

et al. 2007

J. Braz. Chem. Soc.

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A preparação e caracterização eletroquímica do eletrodo de pasta de carbono (EPC) modificado com o mer- [RuCl 3 (dppb)(4-pic)] (dppb= Ph 2 P(CH 2 ) 4 PPh 2 , 4-pic= CH 3 C 5 H 4 N), denominado Rupic, foi investigada. O sistema EPC/Rupic apresentou apenas um par de picos com potencial médio de 0,28 V vs. Ag/AgCl, o qual foi atribuído ao processo de transferência de elétrons do Ru III /Ru II . Este eletrodo modificado apresentou a propriedade de eletrocatalisar a oxidação da dopamina (DA) e do ácido ascórbico (AA) em 0,35 V e 0,30 V, respectivamente. Como a oxidação dos analitos, AA e DA, ocorreu praticamente no mesmo potencial, não foi possível a distinção dos sinais voltamétricos utilizando-se a voltametria cíclica. Esta limitação foi resolvida empregando-se a Regressão de Mínimos Quadrados Parciais (PLSR), a qual permitiu a determinação de quatro amostras sintéticas, com erros de previsão (RMSEP) de 5,55×10 -5 mol L -1 e 7,48×10 -6 mol L -1 para DA e AA, respectivamente.The preparation and electrochemical characterization of a carbon paste electrode (CPE) modified with mer-[Ru0Cl 3 (dppb)(4-pic)] (dppb=Ph 2 P(CH 2 ) 4 PPh 2 , 4-pic=CH 3 C 5 H 4 N), referred to as Rupic, were investigated. The CPE/Rupic system displayed only one pair of redox peaks, with a midpoint potential at 0.28 V vs. Ag/AgCl, which were ascribed to Ru III /Ru II charge transfer. This modified electrode presented the property of electrocatalysing the oxidation of dopamine (DA) and ascorbic acid (AA) at 0.35 V and 0.30 V vs. Ag/AgCl, respectively. Because the oxidation for both AA and DA practically occurred at the same potential, distinguishing between them was difficult with cyclic voltammetry. This limitation was overcome using Partial Least Square Regression (PLSR), which allowed us, with the optimised models, to determine four synthetic samples with prediction errors (RMSEP) of 5.55×10 -5 mol L -1 and 7.48×10 -6 mol L -1 for DA and AA, respectively. Keywords: carbon paste electrodes, ruthenium complexes, dopamine, ascorbic acid, multivariate calibration methodology IntroductionConsiderable progress has been made over the last few years on chemically modified carbon paste electrodes, having an easier and faster procedure to assemble and renew the paste surfaces, low cost, background currents and possibility to incorporate a series of materials. [1][2][3][4][5] Among the materials that may be used in conjunction with carbon paste are the ruthenium-containing compounds such as oxides, mixed valence compounds and complexes. These Ru-based materials possess electrocatalytic properties, which have been used to modify electrodes for electroanalysis of ascorbic acid, 6,7 L-dopa, 8 glucose, 9 benzylic compounds 10 and dopamine. 11 Dopamine (DA) and ascorbic acid (AA), in particular, are relevant from the biomedical and neurochemical point of view, for their importance to human metabolism. DA is involved in the functioning of the central nervous system, in addition to the cardiovascular, renal and hormonal systems, and plays an important role in ...

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“…Classical methods such as refractometry (Pen'kovskii et al, 2004) or densitometry (Bavcar & Kosmerl, 2003) of the distilled samples, as well as gas chromatography (Schmitt & Aderjan, 2004) which are routinely used in in clinics and industry are time-and labour-consuming procedures. In order to replace these methods, a variety of enzymatic and biosensor approaches were developed based on alcohol-specific enzymes isolated from different microbial species: NAD + -dependent alcohol dehydrogenase (Ivanova et al, 2003;Gautier et al, 1990), quinohemoprotein alcohol dehydrogenase (Niculescu et al, 2002), or alcohol oxidase (Gibson et al, 1992;Gonchar et al, 2001Patel et al, 2001) were proposed and applied for the determination of ethanol in complex samples. Alcohol biosensors based on NAD + -dependent alcohol dehydrogenase (ADH) usually exhibit high selectivity, however, due to the need to add the coenzyme NAD + to the sample, ethanol determination is quite expensive using these types of biosensors.…”

Section: Development Of a Reagentless Bienzyme Amperometric Biosensormentioning

confidence: 99%

Amperometric Biosensors for Lactate, Alcohols, and Glycerol Assays in Clinical Diagnostics

Smutok¹,

Gayda²,

Dmytruk³

et al. 2011

Biosensors - Emerging Materials and Applications

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Evaluation of redox mediators for amperometric biosensors: Ru-complex modified carbon-paste/enzyme electrodes

Cited by 46 publications

References 18 publications

Synthesis, Spectroscopic Characterization and pH Dependent Electrochemical Fate of Two Non-Ionic Surfactants

Synthesis, Spectroscopic Characterization and pH Dependent Electrochemical Fate of Two Non-Ionic Surfactants

Simultaneous voltammetric determination of dopamine and ascorbic acid using multivariate calibration methodology performed on a carbon paste electrode modified by a mer-[RuCl3(dppb)(4-pic)] complex

Amperometric Biosensors for Lactate, Alcohols, and Glycerol Assays in Clinical Diagnostics

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