Evaluation of Reid’s Combined Colposcopic Index as a predictor of cervical intraepithelial lesion

Abstract

Background: Carcinoma cervix is the commonest cancer among women worldwide and in India it accounts for 80% of all genital cancers. Screening methods include cervical cytology, human papilloma virus testing and colposcopy. Objective of present study was to evaluate suspicious cervix colposcopically using Reids Colposcopic Index (RCI) and to correlate RCI with histopathological findings.Methods: This was a prospective cross sectional study done on 125 women with clinical diagnosis of suspicious cervix. Colposcopy was performed and grading of the disease was done according to RCI. Positive cases were subjected to cervical biopsy and endocervical curettage was performed in unsatisfactory colposcopy.Results: Colposcopy was done on 125 women with suspicious cervix. Out of 125, sixty two showed abnormal colposcopic findings which were graded according to RCI into Low grade disease predicting histological diagnosis of CIN1 in 47, Intermediate grade disease predicting histological diagnosis of CIN1/2 in 11 and High grade disease predicting histological diagnosis of CIN2/3 in 4 women. Colposcopy of one women suggested invasive carcinoma and was confirmed on histopathology to be microinvasive squamous cell carcinoma. Six women with unsatisfactory colposcopy showed benign histopathology. Sensitivity, specificity, predictive value and false negative rate of colposcopy for invasive disease was 50%, 100%, 100% and 1.60% respectively with 98.40% diagnostic accuracy. Colposcopic diagnosis of invasive disease and histopathology report showed 100% correlation.Conclusions: Correlation between RCI and histopathology was good. Predictive accuracy of colposcopy increased with increasing severity of disease.

Correlation between colposcopic impression using Reid’s colposcopic Index and histopathological grading of premalignant lesions of cervix

“…In a study by Verma et al, the sensitivity, specificity, predictive value and false negative rate of colposcopy for invasive disease was 50%, 100%, 100% and 1.61% respectively. 9 Study by Ramadevi et al correlation between colposcopic findings and biopsy showed a good correlation for higher grade lesions (CIN Il and CIN III). 18 Sensitivity was found to be 83% and specificity was 81%.…”

“…In a study by Verma et al mean age of marriage was 20 years, and development of dysplasia had association with early marriage. 9 Study by Taherian also identified age at marriage of less than 15 years as being significantly associated with cervical cancer. 16 Early marriage before the age of 18 years could be associated with unprotected sexual exposure, early exposure to sexual activities and pregnancy at an early age which are all well known risk factors of cancer cervix.…”

“…study by Bharani et al at Indore, the mean age of patients was 39.93 years 8. In a study by Verma et al mean age was 31-40 years 9.…”