Evaluation of renal and hepatic blood value screening before non‐steroidal anti‐inflammatory drug administration in dogs

Abstract

To evaluate the potential association between signalment, history and physical examination findings and elevated renal and hepatic blood values before non-steroidal anti-inflammatory drug administration in dogs. Secondary objectives were to investigate clinicopathologic differences between dogs that were and were not prescribed a non-steroidal anti-inflammatory drug. Materials and MethOds: Medical records of 81 dogs that underwent renal and hepatic blood value screening before drug administration via a non-steroidal anti-inflammatory drug blood panel were reviewed retrospectively. Patient signalment, history and physical examination findings were recorded. results: Six (7%) dogs had an elevated blood urea nitrogen, 2 (2%) dogs had an elevated creatinine, 24 (30%) dogs had an elevated alanine aminotransferase, 29 (36%) had an elevated aspartate aminotransferase and 14 (17%) had an elevated alkaline phosphatase. Forty-five (56%) dogs had an elevation in at least 1 renal or hepatic blood value. Dogs less than 8 years of age and with a longer duration of clinical signs were less likely to have an elevated renal or hepatic blood value. Dogs with elevated hepatic blood values were less likely to be prescribed a non-steroidal anti-inflammatory drug; however, this was not true for elevated renal parameters alone. clinical significance: The results of this preliminary study suggest that blood value screening before non-steroidal anti-inflammatory drug administration may be important for dogs greater than 8 years of age. Hepatic enzyme elevations may play a greater role in clinical decision making in comparison to renal parameters.

Grapiprant or carprofen following ovariohysterectomy in the cat: analgesic efficacy, hematological, biochemical and urinalysis evaluation

“…Although serum creatinine and blood urea nitrogen are considered relatively insensitive indicators of renal damage, both variables are traditionally used as markers of renal insufficiency and routinely measured before administering NSAIDs. 35 In this study, serum creatinine and urea concentration were not significantly different among groups although the CAR and GRA2 groups had elevated baseline values for both variables. Urinary casts, which might indicate acute tubular necrosis depending on the type of sediment present, 36 were also absent in 81% of the animals 24 h after administering the treatments and are consistent with the biochemical variables.…”