Evaluation of renal function in a specific population of living kidney donors

Rodrigues, Thalyta de Souza; Albuquerque, Ana Letícia Amorim de; Cosme, Fillipe Agra de Oliveira; Oliveira, José Ayrton Macedo Guimarães de; Magalhães, I; Teles, Flávio; Pedrosa, André Falcão

doi:10.1111/jorc.12198

Cited by 2 publications

(1 citation statement)

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“…Azar et al reported 86 donors over a period of 3 years post kidney transplantation and relayed high rates of hypertension (37.5%) and proteinuria (10.4%) despite strict control before kidney donation. In addition, De Souza Rodrigues analyzed 33 live donor patients, the majority female and hypertensive, and showed that many suffered long‐term side effects, such as early markers of glomerular injury and a decrease in GFR. In their report, the donors tended to be older and have higher incidence of hypertension.…”

Section: Discussionmentioning

confidence: 63%

Improved outcomes after live donor renal transplantation for septuagenarians

Pletcher

Koizumi

Nayebpour

et al. 2020

Clinical Transplantation

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The average age of renal transplant recipients in the United States has increased over the past decade. The implications, however, have not been fully investigated. We explored predictors of success and demographic variables related to outcomes in elderly live donor transplantation. Retrospective analysis was performed using the UNOS database between 2001 and 2016. Donor characteristics and the graft failure rate of recipients above and below 70 years of age were compared across four eras: 2001‐2004, 2005‐2008, 2009‐2012, and 2013‐2016. There was a steady increase in average donor age from the first era to the fourth era (40‐44) which was more evident among the septuagenarian patients (43‐50) (P < .001). The 2‐year graft survival rate improved from 92% in the first era to 96% in the fourth era (P < .001), and this was also more prominent in the >70 population (87%‐93%) (P < .001). The >70 recipients were more likely to be non‐Hispanic white (80.1% vs 65.1%, P < .001) and male (70.1% vs 61.0% P < .001), respectively. The donors were more likely to be non‐Hispanic white and female in the >70 population. Live donation in the elderly is justified based on graft survival and patient survival. However, racial and gender differences exist in septuagenarian recipients and their donors.

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Section: Discussionmentioning

confidence: 63%