Evaluation of Renal Functions in Preterm Infants With Respiratory Distress Syndrome

Tabel, Yılmaz; Öncül, Mehmet; Elmas, Ahmet Taner; Güngör, Serdal

doi:10.1002/jcla.21686

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…The urinary B2M concentrations in our study were like those observed in healthy adults [ 66 ], but they were significantly lower than in preterm neonates [ 26 , 27 ], which is consistent with the fact that increasing prematurity is associated with increased glomerular permeability and decreased proximal tubular protein reabsorption [ 28 ]. Both situations lead to lower urinary B2M concentration in the full-term neonates assessed in our study when compared to preterm children.…”

Section: Discussionsupporting

confidence: 89%

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Kamianowska,

Rybi-Szumińska,

Kamianowska

et al. 2024

Med Sci Monit

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Background Serum creatinine, the criterion standard in assessment of renal function, is not reliable for the neonatal period because of its dependence on renal immaturity and maternal creatinine levels. Thus, it is important to study other biomarkers of renal function in neonates. The present study aimed to measure the urinary concentration of renal biomarkers: calbindin, clusterin, GST-pi (glutathione-S-transferase-alpha), KIM-1 (kidney injury molecule 1), MCP-1 (monocyte chemoattractant protein-1), and B2M (beta 2-microglobulin) in healthy term neonates. Material/Methods In the study, we included 80 healthy term neonates – 40 females and 40 males. We collected the neonates’ urine on their first day of life. Urinary concentrations of calbindin, clusterin, KIM-1, MCP-1, and B2M were assessed using an immunoassay for kidney toxicology research. Because dilution of the urine affects the concentrations of urinary biomarkers, we normalized them to the concentration of urinary creatinine (Cr) and present them as biomarker/Cr ratios. Results We obtained the following values of the assessed biomarker/Cr ratios (median [Q1–Q3]): calbindin/Cr.: 197.04 (56.25–595.17), KIM-1/Cr: 0.09 (0.04–0.18), MCP-1/Cr: 0.05 (0.02–0.14), B2M/Cr: 126.12 (19.03–342.48), GST-pi/Cr in boys: 1.28 (0.46–3.77), GST-pi/Cr in girls: 8.66 (2.51–27.82), clusterin/Cr: 4.55 (1.79–12.97) ng/mg Cr. Conclusions We showed the urinary levels of calbindin, clusterin, GST-pi, KIM-1, MCP-1, B2M in white, West Slavic, healthy term neonates. We found that in there is an association between female sex and a higher urinary GST-pi excretion, but urinary excretion of calbindin, clusterin, KIM-1, MCP-1, and B2M is sex-independent. The urinary levels of the assessed biomarkers do not depend on the method of delivery.

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Section: Discussionsupporting

confidence: 89%

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Kamianowska,

Rybi-Szumińska,

Kamianowska

et al. 2024

Med Sci Monit

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“…The same seems to apply to B2M [67]. Increased serum B2M concentrations have recently been associated with respiratory distress syndrome when compared with healthy control newborns, questioning the feasibility of B2M to serve as a marker of neonatal GFR [68]. Questions have been posed as to whether CysC truly does not cross the placenta [23].…”

Section: Alternative Endogenous Biomarkers Of Glomerular Filtration Ratementioning

confidence: 94%

Assessment of glomerular filtration rate in the neonate

Filler

Guerrero-Kanan

Álvarez-Elías

2016

Current Opinion in Pediatrics

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“…Early studies confirmed that the urinary biomarker B2M was significantly higher in perinatal asphyxiated neonates than in controls when oliguria was present, 33 and oliguria in the perinatal period is a sensitive indicator of infants at risk for long‐term neurologic deficits 34 . Evidence also supported subclinical tubular dysfunction, probably secondary to hypoxic stress, combined with high levels of B2M in preterm infants 35 . Not surprisingly, experimental data suggested that cardiomyocytes express and secrete elevated levels of B2M in response to ischemic damage, which could activate fibroblasts in a paracrine manner associated with therapeutic targets relevant for cardiac repair 36 .…”

Section: Discussionmentioning

confidence: 97%

“… 34 Evidence also supported subclinical tubular dysfunction, probably secondary to hypoxic stress, combined with high levels of B2M in preterm infants. 35 Not surprisingly, experimental data suggested that cardiomyocytes express and secrete elevated levels of B2M in response to ischemic damage, which could activate fibroblasts in a paracrine manner associated with therapeutic targets relevant for cardiac repair. 36 In addition, Rist PM and his partners found that high levels of B2M were associated with an increased risk of ischemic stroke among women.…”

Section: Discussionmentioning

confidence: 99%

An integrated analysis of hypoxic–ischemic encephalopathy‐related cell sequencing outcomes via genes network construction

Zhou

Chen

2022

Ibrain

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Hypoxic–ischemic encephalopathy (HIE) is one of the main causes of morbidity and severe neurological deficits in neonates. This study aimed to find core genes and their potential roles in HIE with the help of single‐cell sequencing (SCS) technology and genes network construction. We collected and screened an HIE genes data set from the Pubmed database to analyze differential expression, and the differential values of genes were ≥3 or ≤−3 in gene expression. We constructed a protein–protein interaction (PPI) network by the string, which was also verified by Cytoscape 3.8.2. Functional enrichment analysis was performed to determine the characteristics and pathways of the core genes. We examined two meaningful papers and integrated all genes by SCS, which were classified into 12,093 genes without duplicates, 217 shared genes, and 11,876 distinct genes. Among 217 genes, the signal transducer and activator of transcription (STAT) family was the most targeted gene in the PPI network. Moreover, Gene Ontology and Kyoto encyclopedia of genes and genome analysis showed that the process in response to virus and the JAK‐STAT signaling pathway play significant roles in HIE. We also found that 54 screened genes were highly expressed, while three genes (B2M, VIM, and MRPS30) were different in the heat map and differential genes expression exhibition. VIM, as an essential portion of the brain's cytoskeleton, is closely linked to STAT and neurologic development. From the findings of SCS and bioinformatics predictive analytics model, our outcomes provided a better understanding of the roles of STAT, the JAK‐STAT signaling pathway, and VIM, which can pave an alternative avenue for further studies on HIE progression.

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Evaluation of Renal Functions in Preterm Infants With Respiratory Distress Syndrome

Abstract: Preterm infants with RDS had increased levels of both GST-π and B2-MG levels on PN day 30, suggesting subclinical tubular dysfunction, probably secondary to hypoxic stress.

Cited by 5 publications

References 30 publications

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Assessment of glomerular filtration rate in the neonate

An integrated analysis of hypoxic–ischemic encephalopathy‐related cell sequencing outcomes via genes network construction

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