Evaluation of Renal Glomerular and Tubular Functional and Structural Integrity in Neonates

Awad, H.H.; El-Barbary, Mohamed; Imam, Safaa S.; El-Safty, Ibrahim

doi:10.1097/00000441-200211000-00005

Cited by 43 publications

(32 citation statements)

References 28 publications

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“…Very low concentrations of both high-molecular-weight (HMW) and low-molecular-weight (LMW) proteins are normally present in the urine, due to the function of the glomerular filtration barrier and the reuptake of filtered proteins in the proximal tubule (28,32). A limited number of previous studies have demonstrated a high variation in urine albumin levels between individual preterm neonates (7,10), with the highest levels exhibited by those with a low gestational age at birth and those that are clinically unstable (3,7,10,11,52). Urinary levels of ␤2-microglobulin (␤2-M) have also been shown to be significantly greater in the preterm infant compared with term-born infants throughout the first month of life (2,52,53), and they decrease with increasing gestational and postnatal age (50).…”

mentioning

confidence: 99%

Assessment of renal functional maturation and injury in preterm neonates during the first month of life

Gubhaju

Sutherland

Horne

et al. 2014

American Journal of Physiology-Renal Physiology

108

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mentioning

confidence: 99%

Assessment of renal functional maturation and injury in preterm neonates during the first month of life

Gubhaju

Sutherland

Horne

et al. 2014

American Journal of Physiology-Renal Physiology

108

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“…α 1 -Microglobulin has been used as a marker of tubulointerstitial injuries [19,20]. In the neonatal context, it is well known that increased urinary excretion of microalbumin and α 1 -microglobulin is associated with immature renal function [21]. The close correlation between uEPO levels and urinary levels of microalbumin and α 1 -microglobulin suggests that the increased uEPO level in neonates might be partially due to renal immaturity.…”

Section: Discussionmentioning

confidence: 99%

Urine Erythropoietin Level Is Associated with Kidney and Brain Injury in Critically Ill Neonates

Xiao²,

Yan³

et al. 2013

Neonatology

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Background: Erythropoietin (EPO) is a glycoprotein hormone produced predominantly in the kidneys. The protective effect of exogenous EPO in hypoxic-ischemic brain injury has been thoroughly examined in neonates. However, the metabolism of endogenous EPO in neonates remains unclear. Objectives: We aimed to evaluate the concentration of urinary EPO (uEPO) in critically ill neonates and to identify possible clinical and laboratory variables that may be associated with uEPO levels. Methods: The concentrations of EPO, cystatin-C, microalbumin, and α₁-microglobulin in the first available urine sample during the initial 72 h of life were measured in 103 critically ill neonates. Clinical and laboratory data were collected for each neonate. Results: There was a positive correlation between uEPO levels and urinary levels of cystatin-C (r = 0.265, p = 0.008), microalbumin (r = 0.422, p < 0.001), and α₁-microglobulin (r = 0.421, p < 0.001). The concentration of uEPO was elevated in neonates who developed acute kidney injury (AKI) during the first week of life compared with those without AKI (p = 0.002) and was also elevated in neonates with brain injury, as demonstrated by ultrasound or magnetic resonance imaging, compared to neonates without brain injury (p = 0.008). An increased log₁₀ uEPO level was associated with the occurrence of AKI (OR 2.70, p = 0.007) and brain injury (OR 2.33, p = 0.016). Conclusions: An increased urinary EPO level in the early postnatal period is significantly associated with kidney and brain injury in critically ill neonates.

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“…Likewise, creatinine clearance, one of the most commonly used markers of renal function, is positively correlated with both gestational age and postnatal age [20,21,[29][30][31][32][33][34][35][36][37][38][39]. In addition, preterm neonates excrete high amounts of sodium in the early neonatal period compared to term neonates, with the fractional excretion of sodium inversely correlated with gestational age and postnatal age [29,[39][40][41][42][43].…”

Section: Renal Functionmentioning

confidence: 99%

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Ryan¹,

Black²

2015

J Neonatal Biol

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Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm.

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Evaluation of Renal Glomerular and Tubular Functional and Structural Integrity in Neonates

Cited by 43 publications

References 28 publications

Assessment of renal functional maturation and injury in preterm neonates during the first month of life

Assessment of renal functional maturation and injury in preterm neonates during the first month of life

Urine Erythropoietin Level Is Associated with Kidney and Brain Injury in Critically Ill Neonates

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

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