Evaluation of Renal Transplant Scintigraphy and Resistance Index Performed Within 2 Days After Transplantation in Predicting Long-Term Graft Function

Abstract

Renal transplant scintigraphy performed within 2 days after transplantation is useful in the prediction of long-term graft function at 3 months, 1 year, and 5 years; and it is superior to resistance index.

Can transplant renal scintigraphy predict the duration of delayed graft function? A dual center retrospective study

“…[ 14 ] In two more recent studies, the applicability of a perfusion curve grading scale for Tc-99m DTPA RS was described in which a sensitivity and specificity of respectively 94% and 44% was reported for the prediction of rejection within the first week after KTX and a sensitivity and specificity of 39.5% and 93.7% for the prediction of a serum creatinine rise at three months after KTX. [ 17 , 19 ] Due to differences in Tc-99m DTPA and Tc-99m MAG3 curve shapes, caused by the higher renal extraction rate of MAG3 compared to DTPA, we could not apply this grading scale of Tc-99m DTPA in our study.…”

“…The R20/3 index is a quantitative relationship of retention to uptake ratio, which can be calculated by dividing the Tc-99m MAG3 uptake at 20 minutes by the uptake at 3 minutes. [ 18 , 19 , 20 ] The tubular function slope ( TFS ) reflects the Tc-99m MAG3 uptake by renal tubular cells during the first minutes after Tc-99m MAG3 injection, presented as the linear fit of the curve between 50 and 110 seconds. [ 8 , 11 ] The corrected tubular extraction rate (cTER), in mL/min/1.73m 2 , reflects the Tc-99m MAG3 uptake corrected for the body surface using the renal uptake rate for 1 to 2 minutes after injection and the following regression equation: 9.825X + 11.258 (wherein X is the renal uptake).…”

Renal Transplant Scintigraphy

“…Tc-99m DTPA ile yapılan çalışmalara gelince; Gupta ve ark. (39) tarafından yapılan bir çalışmada posttransplant 1. ve 4. günde yapılan sintigrafilerde HI ve ∆P'nin, grubumuzun yaptığı bir çalışmada da ilk 2 gün içinde elde edilen ∆P ve GW½ indekslerinin uzun dönem prognostik değerinin olduğu anlaşılmıştır (40).…”

The effect of pre-existing HLA sensitization on the renal allograft function according to angionephroscintigraphy results

“…Ангионефросцинтиграфия позволяет качественно и количественно оценить перфузию, фильтрацию и экскрецию почки [1][2][3], что играет важную роль в оценке восстановления функции трансплантированной почки и диагностике осложнений после трансплантации [4,5]. При этом существенное значение имеют отсутствие побочных реакций на радиофармпрепарат (РФП), небольшая лучевая нагрузка и высокая воспроизводимость результатов.…”