Evaluation of Reproducibility of Diffusion Tensor Imaging in the Brachial Plexus at 3.0 T

Ho, Michael; Manoliu, Andrei; Kuhn, Félix P.; Stieltjes, Bram; Klarhöfer, Markus; Feiweier, Thorsten; Marcon, Magda; Andreisek, Gustav

doi:10.1097/rli.0000000000000363

Cited by 33 publications

(34 citation statements)

References 25 publications

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“…There have been several studies reporting intra‐ or interscan reproducibility of the application of DTI in peripheral nervous tissue . For future studies investigating the lumbosacral nerves with DTI, it is essential to have information regarding the variability in diffusion parameters between subjects vs. the variability between scans within one subject.…”

Section: Discussionmentioning

confidence: 99%

Multicenter reproducibility study of diffusion MRI and fiber tractography of the lumbosacral nerves

Haakma

Hendrikse

Uhrenholt

et al. 2018

Magnetic Resonance Imaging

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BackgroundDiffusion tensor imaging (DTI) has been applied in the lumbar and sacral nerves in vivo, but information about the reproducibility of this method is needed before DTI can be used reliably in clinical practice across centers.PurposeIn this multicenter study the reproducibility of DTI of the lumbosacral nerves in healthy volunteers was investigated.Study TypeProspective control series.SubjectsTwenty healthy subjects.Field Strength/Sequence3T MRI. 3D turbo spin echo, and 3.0 mm isotropic DTI scan.AssessmentThe DTI scan was performed three times (twice in the same session, intrascan reproducibility, and once after an hour, interscan reproducibility). At site 2, 1 week later, the protocol was repeated (interweek reproducibility). Fiber tractography (FT) of the lumbar and sacral nerves (L3–S2) was performed to obtain values for fractional anisotropy, mean, axial, and radial diffusivity.Statistical TestsReproducibility was determined using the intraclass correlation coefficient (ICC), and power calculations were performed.ResultsFT was successful and reproducible in all datasets. ICCs for all diffusion parameters were high for intrascan (ranging from 0.70–0.85), intermediate for interscan (ranging from 0.61–0.73), and interweek reliability (ranging from 0.58–0.62). There were small but significant differences between the interweek diffusivity values (P < 0.0005). Depending on the effect size, nerve location, and parameter of interest, power calculations showed that sample sizes between 10 and 232 subjects are needed for cross‐sectional studies.Data ConclusionWe found that DTI and FT of the lumbosacral nerves have intermediate to high reproducibility within and between scans. Based on these results, 10–58 subjects are needed to find a 10% change in parameters in cross‐sectional studies of the lumbar and sacral nerves. The small significant differences of the interweek comparison suggest that results from longitudinal studies need to be interpreted carefully, since small differences may also be caused by factors other than disease progression or therapeutic effects. Level of Evidence: 1 Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;48:951–963.

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Section: Discussionmentioning

confidence: 99%

Multicenter reproducibility study of diffusion MRI and fiber tractography of the lumbosacral nerves

Haakma

Hendrikse

Uhrenholt

et al. 2018

Magnetic Resonance Imaging

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“…A larger torso or spine coil has been used for the lumbrosacral plexus. Previous studies have imaged the brachial plexus using coils covering the spinal cord to the axilla with a neurovascular coil and combined chest elements . Anecdotally, we have had the greatest success with regard to adequate SNR and coverage with two 16‐channel flexible extremity arrays sandwiched around the shoulder and back.…”

Section: General Recommendations For Peripheral Nerve Dtimentioning

confidence: 99%

Peripheral nerve diffusion tensor imaging: Overview, pitfalls, and future directions

Jeon

Fung²,

Koch

et al. 2017

Magnetic Resonance Imaging

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“…Younger patients with shorter duration of symptoms and fewer narcotics used enjoy better results in the long-term follow up of patients surgically treated for nTOS [6,43]. Patients with chronic pain syndromes, smoking, age ≥ 40 years, and opioid use have less favorable outcomes [44]. Patients who are on chronic opioids are challenging to diagnose, and unless physical exam and imaging findings are clear and convincing, operative treatment should probably be avoided.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Thoracic Outlet Syndrome

2018

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Evaluation of Reproducibility of Diffusion Tensor Imaging in the Brachial Plexus at 3.0 T

Abstract: Diffusion tensor imaging metrics in the brachial plexus are reproducible. Future applications of DTI for a possible clinical use should be further investigated.

Cited by 33 publications

References 25 publications

Multicenter reproducibility study of diffusion MRI and fiber tractography of the lumbosacral nerves

Multicenter reproducibility study of diffusion MRI and fiber tractography of the lumbosacral nerves

Peripheral nerve diffusion tensor imaging: Overview, pitfalls, and future directions

Diagnosis and Treatment of Thoracic Outlet Syndrome

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