Evaluation of Respiratory Virus Pathogen from Patients Presenting with Influenza like Illness at Various Hospitals in Delhi, India

Abstract

Background: Respiratory viruses have been widely circulating in human populations and its variants have caused, and continue to cause, substantial morbidity and mortality worldwide. Objective:The objective of this study was to compare the presence of various circulating respiratory virus among the population in Delhi region. Materials and Method: The epidemiology and burden of human respiratory viruses were examined in a cohort of 106 patients from Delhi, India, by using real-time quantitative reverse transcription polymerase chain reaction. Results: Of the 106 screened samples tested,35.84% patients were found positive for influenza A virus, 19.81% for Human Metapneumovirus (hMPV),5.66% for Rhinovirus (HRV), 3.77%for Parainfluenza (PIV) type 4 and Human Enterovirus (HEV), 2.83% for Human Coronavirus (HCoV) OC43, while 0.94% for influenza B, coronavirus NL63 and 229E, Parainfluenza type-2 and 3 and Bocavirus. The analysis revealed that Parainfluenza (PIV-1, 2 and 3), Respiratory Syncytial Virus (RSV) A and B, and Human Bocavirus (HBoV) are not commonly circulating among general population. Conclusion: The metapneumovirus and influenza A virus are important respiratory pathogens in patients. Apart from these HRV and HEV embark to the clinical significance in child care. Influenza and HRV caused the highest-impact illnesses. The current study depicts the burden of respiratory viruses in current population.