Evaluation of restless legs syndrome and sleep disorders in patients with psoriatic arthritis

The Impact of Comorbidity on Patient-Reported Outcomes in Psoriatic Arthritis: A Systematic Literature Review

“…1). Ultimately, 66 of the 84 studies were excluded from inclusion in the systematic literature review (Table 1) [12,, and 18 articles were included [9,14,[83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98], one of which had been identified from the hand search (see Tables 2 and 3 for more detail).…”

“…Most of the studies included in the systematic literature review were cross-sectional [9,84,85,[87][88][89][90][92][93][94][95][96][97], although prospective observational studies were also found [14,83,86,91,98], and most were of moderate quality (predominantly Oxford CEBM levels of evidence 2b or 4). The total number of PsA patients included in each study ranged from 3571 [91] to 40 [97].…”

“…The most frequently analysed PROs were function [83,84,86,89,92,94], quality of life [9,14,84,[91][92][93] and fatigue [83,85,87,93], but some studies evaluated the impact of comorbidity on pain [83,84,91,98], work disability [88] or sleep quality [93,96,97] The impact of comorbidity on PROs of PsA patients was examined using the CCI in two large, high-quality prospective cohorts [83,86]. In the first study (using DANBIO, a nationwide registry of biological therapies in Denmark), the authors noted that a higher score on the CCI was associated with worse function, pain, fatigue and PGA (univariate analyses) [83].…”

“…In some studies the impact of an individual comorbidity was examined, such as obesity [86,98], FM [9,96] or anxiety and depression [85,87], while in other studies the impact of the number of comorbidities was examined [14,95], using indexes such as the CCI or FCI. With respect to the PROs, we included a very long list in our review, including function [83,86,92], quality of life [14,84,93], fatigue [83,85], pain [83,91,98], work disability [88] and/or or sleep quality [93,6,97].…”

“…A study was also selected for inclusion in our systematic literature review which enrolled 50 PsA patients with restless legs syndrome [93]. In the multivariate analyses and in the comparison with patients who did not have the syndrome, an association was found with the FSS (b coefficient 0.243, p = 0.003), PSQI (b coefficient 0.299, p = 0.002) and the SF-36 (physical component) (b coefficient 0.242, p = 0.004).…”