Evaluation of restless legs syndrome in fibromyalgia syndrome: An analysis of quality of sleep and life

Civelek, Gül Mete; Cıftkaya, Pınar Oztop; Karataş, Metin

doi:10.3233/bmr-140478

Cited by 27 publications

(14 citation statements)

References 34 publications

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“…Although both diseases are known to be associated, differential diagnosis might be difficult in patients with severe pain in the lower extremities. The majority of patients with FM have moderate or severe RLS (39). However, no difference was detected between patients with RLS (moderate/severe/very severe) with and without FM in terms of the severity of RLS in our study.…”

Section: Discussioncontrasting

confidence: 48%

The Prevalence of Fibromyalgia in Patients with Restless Legs Syndrome

Yılmaz¹,

Cantürk²,

Düz³

et al. 2016

tnd

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Objective: To determine the prevalence of fibromyalgia (FM) in patients with Restless legs syndrome (RLS), and to evaluate the relationship of FM and the scales of quality of life. Materials and Methods:Thirty patients aged between 18-65 years (20 females, 10 males) with RLS and 30 healthy control subjects (17 female, 13 male) participated in our study. The patients were assessed using the the RLS Severity Rating Scale. The Pittsburg Sleep Quality Index (PSQI), Beck Depression Inventory, Beck Anxiety Questionnaire, and Quality of Life Short form-36 (SF-36) were given to both the patient and control group. The American College of Rheumatology criteria were used to diagnose FM. Results:The average age of the patients was 44.73±11.23 years, the average age of the control group was 46.00±12.23 years. The prevalence of FM was 36.7% in the patient group and 6.7% in the control group (p=0.01). PSQI, depression and anxiety scores were significantly worse in the patient group (p=0.0001; p=0.004; p=0.000). The patients with RLS had higher scores of mental health, social functioning, pain, and general perception of SF-36, and scale for the evaluation of quality of life (p=0.004; p=0.023; p<0.001; p=0.001; p=0.13); the scores for physical and emotional limitations did not differ between the patient and the control group. However, if a patient with RLS had additional FM symptoms, the general perception scores of the body were worse (p=0.029). When we compared the scores of the patients with both RLS and FM with the healthy group, the anxiety scores were the most increased (three times). Conclusion:The prevelance of FM was frequent (36.67%) in patients with moderate and severe RLS. RLS impairs quality of life. However, coexistence of the two diseases only worsened patients' assessments of their own health score, and affected their anxiety scores the most.

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Section: Discussioncontrasting

confidence: 48%

The Prevalence of Fibromyalgia in Patients with Restless Legs Syndrome

Yılmaz¹,

Cantürk²,

Düz³

et al. 2016

tnd

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“…Various studies showed the increased frequency of RLS and its association with poor sleep quality in many diseases such as chronic renal failure, [26] fibromyalgia, [27] ankylosing spondylitis, [28] lumbar radiculopathy, [29] inf lammatory bowel disease, [30] or primary biliary cirrhosis. [31] However, there exist only a small number of studies which investigate the relationship between RLS and allergic diseases in adults, but not in children.…”

Section: Discussionmentioning

confidence: 99%

Restless legs syndrome in children with allergic rhinitis: A comparative study on frequency, severity and sleep quality

Filiz¹

2018

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the frequency and severity of restless legs syndrome (RLS) and its relationship with sleep quality in children with allergic rhinitis (AR) with the hypothesis that comorbid RLS may be an additional causative factor of sleep disturbances in pediatric AR. Patients and methods: A total of 143 children with AR (aged 8-18 years) and 144 healthy control subjects (aged 8-18 years) were included. The diagnosis of AR was established on history, clinical examination and skin prick test according to the Allergic Rhinitis and its Impact on Asthma guidelines. Presence of RLS was determined using the International RLS study group (IRLSSG) criteria. The severity of RLS was assessed using the IRLSSG rating scale. Sleep quality was evaluated by Pittsburgh Sleep Quality Index (PSQI). Results: Thirteen patients (9.1%) in AR group, and six children (4.2%) in control group had RLS (p=0.159). The frequency of RLS in AR group was higher than two folds when compared to the control group; however, the difference was not statistically significant. Restless legs syndrome severity score was significantly higher in AR group than control group (15.00 [11-20] and 11.00 [10-16] respectively, p=0.046). Total PSQI scores were similar between groups. Also, no significant differences were observed in total PSQI scores of AR patients with or without RLS. Conclusion: Restless legs syndrome was not more common but was more severe in children with AR. There was no evidence that RLS has an obvious effect on sleep quality in children with AR.

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“…Sleep disorders like obstructive sleep apnea and restless legs syndrome appear to be more common in patients with FMS, particularly in male patients, than in the general population [151][152][153][154][155][156], and FMS may be more prevalent among patients with sleep apnea than in the general population [157]. The presence of such sleep disorders is associated not only with worse perceived sleep quality, but also with pain, fatigue, and greater symptoms severity (assessed with the Fibromyalgia Impact Questionnaire, FIQ) [151,156].…”

Section: Sleepmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

229

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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Evaluation of restless legs syndrome in fibromyalgia syndrome: An analysis of quality of sleep and life

Abstract: Presence of RLS should be investigated in every patient with FMS and treatment plans should also cover RLS in case of coexistance with FMS. Prospective cohort studies are needed for better explanation of FMS and RLS coexistance.

Cited by 27 publications

References 34 publications

The Prevalence of Fibromyalgia in Patients with Restless Legs Syndrome

The Prevalence of Fibromyalgia in Patients with Restless Legs Syndrome

Restless legs syndrome in children with allergic rhinitis: A comparative study on frequency, severity and sleep quality

Fibromyalgia: A Critical and Comprehensive Review

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