Evaluation of results of chromosome analyses on lymphocytes of TCDD exposed subjects after the Seveso accident

Mottura, A.; Zei, Gianna; Nuzzo, Fiorella; Crimaudo, C.; Giorgi, Raffaele De; Veneroni, Paola; Paggini, L.; Mocarelli, P.; Fraccaro, M.; Nicoletti, B.; Carli, L. De

doi:10.1016/0165-1161(81)90087-x

Cited by 6 publications

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Effect of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the Rhesus monkey

Lim¹,

Jacobson‐Kram²,

Bowman

et al. 1987

Cell Biol Toxicol

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Frequencies of sister chromatid exchanges and chromosomal aberrations were examined in peripheral lymphocytes of Rhesus monkeys which had been fed a diet containing 25 parts per trillion 2,3,7,8-tetrachlorodibenzo-p-dioxin for a period of 4 years. When compared to non-exposed control animals, no significant differences were noted for either of these cytogenetic endpoints. In addition, there was not a significant difference in sister chromatid exchange response to a challenge dose of mitomycin C in cells from 2,3,7,8-tetrachlorodibenzo-p-dioxin exposed animals compared to controls. Our results confirm the lack of genotoxic effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.

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Effect of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the Rhesus monkey

Lim¹,

Jacobson‐Kram²,

Bowman

et al. 1987

Cell Biol Toxicol

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The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis

Lernia

Crimaudo

Pacchetti³

1982

Hum Genet

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Satellite associations were used as parameters to test nucleolar organizer activity. Assuming that toxic and/or mutagenic agents may affect the ribosomal genes, satellite associations in human lymphocytes were analysed following exposure to X-rays and compared with the satellite association pattern of subjects exposed to TCDD. A significant decrease in the satellite association frequency in D group chromosomes was found both in irradiated lymphocytes and in subjects exposed to Dioxin. The findings seem to be in accordance with the hypothesis based on random damage of functional nucleolar organizing regions.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: Gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion

Whysner

Williams

1996

Pharmacology & Therapeutics

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Evaluation of results of chromosome analyses on lymphocytes of TCDD exposed subjects after the Seveso accident

Cited by 6 publications

References 0 publications

Effect of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the Rhesus monkey

Effect of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the Rhesus monkey

The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis

2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: Gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion

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