Evaluation of retina nerve fiber layer, ganglion cell-inner plexiform layer and lamina cribrosa in clinically unilateral exfoliative glaucoma

Demirtaş, Atılım Armağan; Duru, Zeynep; Duru, Necati; Erdoğan, Hakika

doi:10.1007/s10792-020-01452-y

Cited by 1 publication

(1 citation statement)

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“…Optical coherence tomography (OCT) is an intravascular imaging technology widely used for the early diagnosis and management of ophthalmic diseases [ 134 , 135 ]. Previous research showed that the thickness of the two inner retina layers, the retinal nerve fibre layer (RNFL) and ganglion cell inner plexiform layer (GCIPL), could change at different glaucoma stages, suggesting these indices could function as biomarkers for predicting glaucoma [ 136 , 137 ]. A two-sample MR analysis using OCT images from 31,434 UK Biobank participants identified a relationship between morphological retinal phenotypes (RNFL and GCIPL) and POAG [ 138 ].…”

Section: Mr Ophthalmology Studiesmentioning

confidence: 99%

Mendelian randomization analyses in ocular disease: a powerful approach to causal inference with human genetic data

Liu

Huang

et al. 2022

J Transl Med

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Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies cannot avoid confounding factors from interventions, human eye composition and structure are unique, thus, eye disease pathogenesis, which greatly impairs quality of life and visual health, remains to be fully explored. Notwithstanding, inheritance has had a vital role in ophthalmic disease. Mendelian randomization (MR) is an emerging method that uses genetic variations as instrumental variables (IVs) to avoid confounders and reverse causality issues; it reveals causal relationships between exposure and a range of eyes disorders. Thus far, many MR studies have identified potentially causal associations between lifestyles or biological exposures and eye diseases, thus providing opportunities for further mechanistic research, and interventional development. However, MR results/data must be interpreted based on comprehensive evidence, whereas MR applications in ophthalmic epidemiology have some limitations worth exploring. Here, we review key principles, assumptions and MR methods, summarise contemporary evidence from MR studies on eye disease and provide new ideas uncovering aetiology in ophthalmology.

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