Evaluation of retinal and optic nerve vasculature by optic coherence tomography angiography in Migraine with Aura

Karahan, Mine; Erdem, Seyfettin; Ava, Sedat; Kaya, Adar Aslan; Demirtaş, Atılım Armağan; Keklíkçí, Uğur

doi:10.1016/j.jfo.2021.02.018

Cited by 8 publications

(27 citation statements)

References 21 publications

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Section: Resultsmentioning

confidence: 99%

“…Measurement of FAZ was performed by eight authors ( 1 , 17 , 19 , 20 , 22 , 23 , 28 , 29 ). Six studies ( 1 , 17 , 20 , 22 , 23 , 29 ) reported FAZ in patients with MA, three of which ( 1 , 23 , 29 ) showed increased FAZ compared with HC, while the other three ( 17 , 20 , 22 ) reported no significant difference. Among the six studies that reported FAZ in MO patients, only one study ( 28 ) stated that FAZ increased in MO patients compared with HC (MA vs. HC: 0.35 ± 0.11 vs. 0.24 ± 0.12), while the remaining five ( 1 , 17 , 19 , 20 , 23 ) showed no significant difference.…”

Section: Resultsmentioning

confidence: 99%

“…Measurement of foveal and parafoveal SCP VD in the SCP was performed by five authors ( 1 , 17 – 19 , 22 ). Three studies ( 1 , 17 , 22 ) reported foveal SCP VD in patients with MA, two of which ( 1 , 17 ) showed decreased foveal SCP VD in patients with MA compared with HC, while one ( 22 ) found no statistical difference (MA vs. HC: 30.93 ± 5.46 vs. 30.21 ± 5.12). Among the four studies that reported foveal SCP VD in MO patients, only one of them ( 17 ) discovered decreased foveal SCP VD in MO patients (MO vs. HC: 21.1 ± 6.7 vs. 24.2 ± 9.6), while the rest ( 1 , 18 , 19 ) showed no statistical difference.…”

Section: Resultsmentioning

confidence: 99%

“…The foveal and parafoveal regions may be defined differently in different studies. In five studies ( 1 , 18 , 20 , 22 , 23 ), the foveal region is defined as the 1 mm diameter circle centered at the fovea, while in the other two studies ( 17 , 19 ), it is defined as the 0.6 mm diameter circle centered at the fovea. The parafoveal region refers to a ring area in all studies, but there are differences in its size.…”

Section: Methodsmentioning

confidence: 99%

“…The parafoveal region refers to a ring area in all studies, but there are differences in its size. The parafoveal region is defined as 1-3 mm diameter ring in four studies ( 1 , 18 , 20 , 22 ), while it is defined 0.6–2.5 mm diameter ring in other two studies ( 17 , 19 ). The percentage of the area taken by flowing blood vessels is defined as the VD ( 24 ).…”

Section: Methodsmentioning

confidence: 99%

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Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis

Yu²,

Liu³

et al. 2022

Front. Neurol.

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ObjectiveThis study aimed to evaluate the features of macular microvasculature with optical coherence tomography angiography (OCTA) among migraine patients.MethodsWe systematically searched PubMed, Web of Science, Embase, and Cochrane Library for studies that evaluated the macular microvasculature of migraine patients. The weighted mean differences (WMDs) of the foveal avascular zone (FAZ), foveal superficial capillary plexus (SCP) vessel density (VD), parafoveal SCP VD, foveal deep capillary plexus (DCP) VD, and parafoveal DCP VD with 95% confidence intervals (CIs) among migraine with aura (MA) group, migraine without aura (MO) group, and healthy controls (HC) group were analyzed using a random-effect model. P < 0.05 was considered significant in statistical analyses. Publication bias was assessed using funnel plots and statistical tests (Egger's test and Begg's test).ResultsNine studies covering 675 individuals were enrolled in this meta-analysis ultimately. The FAZ of MA patients was not significantly different from HC (WMD = 0.04, 95% CI −0.00 to 0.09). However, the FAZ of MA was significantly larger than that of HC after correction of publication bias by trim and fill method (WMD = 1.03, 95% CI 0.99 to 1.08). The FAZ of MO patients was similar to that of HC (WMD = 0.03, 95% CI −0.00 to 0.07), while smaller than that of MA patients (WMD = 0.05, 95% CI 0.01 to 0.09). VD of the SCP, either in the foveal or parafoveal area, was not significantly different among the three groups. As for DCP, VD in MA patients was lower when compared with HC in the parafovea (WMD = −1.20, 95% CI −1.88 to −0.51).ConclusionsWe found that there was a larger FAZ in MA compared with HC after adjusting for publication bias. The FAZ in MO was not significantly different from that in HC, but significantly lower than that in MA. There was no significant difference in either foveal or parafoveal VD of SCP among MA, MO, and HC participants, while the parafoveal VD of the DCP in MA was lower than that of the HC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis

Yu²,

Liu³

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

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Evaluation of retinal perfusion density and foveal avascular zone in migraine subjects with and without aura

Walha,

Sonda Moalla,

Rekik

et al. 2024

Journal of Clinical Neuroscience

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Assessment of the Optic Disc and Retinal Microvasculature by Optical Coherence Tomography Angiography in Patients With Pediatric Migraine

Kurtul¹,

Sipal²,

Akbaş³

2022

Journal of Neuro-Ophthalmology

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Background:Migraine, as a chronic neurovascular disease, is known to be a risk factor for retinal and optic nerve head damage. Herein, we aimed to evaluate the optic disc and retinal microvasculature in pediatric migraine (PM) patients using optical coherence tomography angiography (OCTA).Methods:Forty-six eyes of 23 patients with PM without aura (PM group) and 46 eyes of 23 age- and sex-matched healthy subjects (control group) were included in this cross-sectional prospective study. Demographic features and ophthalmological examination including OCTA measurements were evaluated. OCTA was performed with 6- × 6-mm sections for macula and 4.5- × 4.5-mm sections for optic nerve head in all eyes. Foveal retinal thickness (FRT), peripapillary retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of the retina, and optic disc were analyzed and compared between the groups. All measurements of the PM patients were taken in the attack-free period.Results:The mean ages of the PM group and control group were 11.17 ± 3.3 and 11.83 ± 2.8 years, respectively (P = 0.479). Gender and mean intraocular pressures were similar between the groups. The mean central corneal thickness levels in the PM group were significantly lower than control group, 548.28 ± 26.3 µm and 562.04 ± 24.5 µm, respectively (P = 0.011). There was no significant difference regarding average and all quadrant RNFL thicknesses, foveal avascular zone and flow areas, deep vessel densities, and optic disc capillary densities between the groups. However, compared with the control group, the PM group showed significant higher values of FRT, and lower values of superficial whole and parafoveal vessel densities (247.28 ± 15.8 µm vs 285.93 ± 11.1, P < 0.001, 51.85 ± 2.4% vs 50.31 ± 4.0%, P = 0.02, 55.09 ± 2.3% vs 53.5 ± 3.5%, P = 0.01, respectively). Disease duration and attacks/year did not show any significant correlations with OCTA values.Conclusions:PM seems to be associated with lower superficial whole and parafoveal vessel densities because of hypoperfusion and ischemia. OCTA may be suggested for use in follow-up and management of PM patients.

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Evaluation of retinal and optic nerve vasculature by optic coherence tomography angiography in Migraine with Aura

Cited by 8 publications

References 21 publications

Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis

Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis

Evaluation of retinal perfusion density and foveal avascular zone in migraine subjects with and without aura

Assessment of the Optic Disc and Retinal Microvasculature by Optical Coherence Tomography Angiography in Patients With Pediatric Migraine

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