Evaluation of retinol levels in human colostrum in two samples collected at an interval of 24 hours

Ribeiro, Karla Danielly da Silva; Araújo, Katherine Feitosa de; Pereira, Michelle C.; Dimenstein, Roberto

doi:10.2223/jped.1646

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Procedures were adapted as described by Ribeiro et al. 17 for HM samples. Retinol concentrations ≤0.70 µmol/L in serum and ≤1.05 µmol/L in milk were considered insufficient.…”

Section: Methodsmentioning

confidence: 99%

“…Retinol concentrations were determined by high performance liquid chromatography (HPLC) according to the procedures for serum samples proposed by Arnaud et al 15 and by Giuliano et al 16 . Procedures were adapted as described by Ribeiro et al 17 for HM samples. Retinol concentrations 0.70 mmol/L in serum and 1.05 mmol/L in milk were considered insufficient.…”

Section: Sample Analysismentioning

confidence: 99%

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Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

et al. 2018

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ObjectivesTo analyse intake of vitamin A (VA) and retinol concentrations in maternal blood, breast milk (BM), and the umbilical cord (UC) of newborns, and to determine the associations among these variables.MethodsWe performed a cross-sectional, epidemiological study of 180 mother–newborn dyads. Maternal and UC blood samples and BM were collected. VA intake by the mother over 30 days was assessed using a questionnaire.ResultsMean retinol concentrations in maternal serum, the UC, and BM were 0.65 ± 0.27, 0.36 ± 0.18, and 2.95 ± 2.70 µmol/L, respectively. Retinol concentrations <0.70 µmol/L were found in 57.2% of maternal blood samples and in 94.9% of UC samples. A total of 27.9% of BM samples showed retinol concentrations <1.05 µmol/L. Mean VA intake by the mothers was 1041.33 ± 1187.86 µg retinol activity equivalents/day and was inadequate (<550 µg retinol activity equivalents/day) in 44.7%.ConclusionsHigh proportions of insufficient retinol concentrations were observed in the UC, maternal blood, and BM. A high percentage of pregnant women had inadequate VA intake. Mothers with insufficient serum retinol concentrations had newborns with lower retinol concentrations in the UC. Higher retinol concentrations were observed in maternal blood and the UC with a higher VA intake.

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“…Procedures were adapted as described by Ribeiro et al. 17 for HM samples. Retinol concentrations ≤0.70 µmol/L in serum and ≤1.05 µmol/L in milk were considered insufficient.…”

Section: Methodsmentioning

confidence: 99%

Section: Sample Analysismentioning

confidence: 99%

Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

et al. 2018

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“…5 lysozyme, and lymphocytes by 60%-75%, whereas freezing at +4 C for 24 hours produces a 40% decrease of many of the same bioactive substances. [10][11][12] Is Lactoferrin Responsible for the Antiinfective Actions of Human Milk?…”

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confidence: 99%

Clinical Benefits of Lactoferrin for Infants and Children

Manzoni

2016

The Journal of Pediatrics

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To discuss the potential clinical benefits of lactoferrin in preterm and term infants, as well as in young children and to review information on the burden of neonatal sepsis. Current evidence on the mechanisms that explain the role of human milk in the neonatal and infant anti-infective responses will be briefly reviewed and preclinical research data on the potential mechanisms of action by which lactoferrin may impact infant gut health, gut immune development and functions, including the lactoferrin effects on the neonatal microbiome, will be examined. Finally, updated translational research on lactoferrin will be presented and discussed and the current evidence from prospective randomized controlled trials in neonates, infants, and toddlers will be analyzed. These randomized controlled trials demonstrate that lactoferrin has a clinically significant impact on feeding, the microbiome, and clinical outcomes in neonates and infants.

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“…Some studies have suggested that colostrum may be a biochemical indicator of vitamin A status; therefore, breast milk vitamin A can be used for monitoring the impact of vitamin Arelated intervention programs as it is easy to obtain in a non-invasive manner [37,39].…”

Section: Discussionmentioning

confidence: 99%

Maternal Supplementation with <em>RRR</em>-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

Dametto¹,

Lira²,

Melo³

et al. 2017

Preprint

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Vitamin A and E are important during pregnancy, the neonatal period, and childhood.The objective of this study was to assess whether maternal RRR-α-tocopherol supplementation affects serum and breast milk retinol. Serum was collected at baseline and twenty days later, and breast milk, at baseline, and on days 1, 7, and 20 after delivery.After the baseline serum collection, the supplemented group (n=16) received a single 400 IU of RRR-α-tocopherol. The control group (n=18) was only performed collections.Retinol and alpha tocopherol levels were determined by liquid chromatography. Serum retinol and alpha tocopherol at baseline and 20 days after delivery indicated proper vitamin A (> 20 µg/dL) and E (> 516 μg/dL) statuses in the control and supplemented groups (p > 0.05). Colostrum retinol levels on days 1 and 7 after delivery were significantly higher in the supplemented group (p = 0.018 and p = 0.012, respectively).Maternal vitamin E supplementation increased colostrum retinol by 52.23% and 111.2%, 24 hours and 7 days, respectively. However, retinol in mature milk did not differ between the groups (p > 0.05). In conclusion, the supplementation with 400 IU of RRR-α-tocopherol improved vitamin A bioavailability in breast milk.

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Evaluation of retinol levels in human colostrum in two samples collected at an interval of 24 hours

Abstract: Evaluation of retinol levels in human colostrum in two samples collected at an interval of 24 hours Avaliação dos níveis de retinol no colostro humano coletado no intervalo de 24 horas

Cited by 5 publications

References 7 publications

Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

Clinical Benefits of Lactoferrin for Infants and Children

Maternal Supplementation with <em>RRR</em>-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

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Evaluation of retinol levels in human colostrum in two samples collected at an interval of 24 hours

Abstract: Evaluation of retinol levels in human colostrum in two samples collected at an interval of 24 hours Avaliação dos níveis de retinol no colostro humano coletado no intervalo de 24 horas

Cited by 5 publications

References 7 publications

Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord

Clinical Benefits of Lactoferrin for Infants and Children

Maternal Supplementation with <em>RRR</em>-&alpha;-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

Contact Info

Product

Resources

About

Maternal Supplementation with <em>RRR</em>-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol