Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2

Belchor, Mariana Novo; Gaeta, Henrique Hessel; Rodrigues, Caroline Fabri Bittencourt; Costa, Carolina Bacci; Toyama, Daniela de Oliveira; Passero, Luiz Felipe Domingues; Laurenti, Márcia Dalastra; Toyama, Marcos Hikari

doi:10.3390/molecules22091441

Cited by 39 publications

(33 citation statements)

References 37 publications

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“…Rhamnetin ( 6 ) is a methylated derivative of quercetin. The presence of 3OH on the C-ring of rhamnetin may contribute to both its anti-inflammatory and enzymatic inhibition of secretory phospholipase A2 (sPLA2), and the methylation of ring A may provide the increase in cell viability and a low creatine kinase (CK) level induced by sPLA2 [ 51 ]. These results showed that compound ( 6 ) could be a candidate as a natural compound for the development of new anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 99%

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Nawrot

Budzianowski

Nowak

et al. 2021

IJMS

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Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of Stizolophus balsamita growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and natural steroids have been isolated for the first time in the genus Stizolophus. The MTT assay was employed to study in vitro cytotoxic effects of the taxifolin against human fibroblasts. We also evaluate the possible biological properties/cosmetic effects of Stizolophus balsamita extract and taxifolin on the human skin. Sixty healthy Caucasian adult females with no dermatological diseases were investigated. We evaluate the effects of S. balsamita extract and taxifolin on skin hydration and transepidermal water loss (TEWL). It was revealed that S. balsamita extract might decrease TEWL level and fixed the barrier function of the epidermis. The presence of bioactive phytochemical constituents in S. balsamita inflorescences makes them a valuable and safe source for creating new cosmetics and medicines.

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Section: Discussionmentioning

confidence: 99%

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Nawrot

Budzianowski

Nowak

et al. 2021

IJMS

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“…Members of the flavone family, but not the chalcones, have been reported to be positive modulators of mitochondrial biogenesis and function, although the mechanism of action remains unknown (21). Both classes of molecules can inhibit phospholipase A2 (PLA2) enzymes (22,23).…”

Section: Discussionmentioning

confidence: 99%

Neuron-based high-content assay and screen for CNS active mitotherapeutics

et al. 2020

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Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule modulators of neuronal mitostasis (MnMs). Most MnMs that increased mitochondrial content, length, and/or health also increased mitochondrial function without altering neurite outgrowth. A subset of MnMs protected mitochondria in primary neurons from Aβ(1–42) toxicity, glutamate toxicity, and increased oxidative stress. Some MnMs were shown to directly target mitochondria. The top MnM also increased the synaptic activity of hippocampal neurons and proved to be potent in vivo, increasing the respiration rate of brain mitochondria after administering the compound to mice. Our results offer a platform that directly queries mitostasis processes in neurons, a collection of small-molecule modulators of mitochondrial dynamics and function, and candidate molecules for mitotherapeutics.

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“…From a molecular point of view, clove buds contain flavonoids like β-caryophyllene, kaempferol, and rhamnetin, which contribute to clove anti-inflammatory properties [ 85 , 86 , 87 , 88 , 89 ]. In experimental animal models, eugenol (at 200 and 400 mg/kg doses) was shown to reduce the volume of pleural exudates without changing the total count of blood leukocytes, which indicates the anti-inflammatory activity of this molecule [ 90 ].…”

Section: Clove ( Syzygium Aromaticum L) In Hermentioning

confidence: 99%

Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility

2021

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The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2 infection is enormously affecting the worldwide health and economy. In the wait for an effective global immunization, the development of a specific therapeutic protocol to treat COVID-19 patients is clearly necessary as a short-term solution of the problem. Drug repurposing and herbal medicine represent two of the most explored strategies for an anti-COVID-19 drug discovery. Clove (Syzygium aromaticum L.) is a well-known culinary spice that has been used for centuries in folk medicine in many disorders. Interestingly, traditional medicines have used clove since ancient times to treat respiratory ailments, whilst clove ingredients show antiviral and anti-inflammatory properties. Other interesting features are the clove antithrombotic, immunostimulatory, and antibacterial effects. Thus, in this review, we discuss the potential role of clove in the frame of anti-COVID-19 therapy, focusing on the antiviral, anti-inflammatory, and antithrombotic effects of clove and its molecular constituents described in the scientific literature.

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Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2

Cited by 39 publications

References 37 publications

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Neuron-based high-content assay and screen for CNS active mitotherapeutics

Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility

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