Evaluation of Risk Factors for Arteriovenous Fistula Failure in Patients Undergoing Hemodialysis

Sarı, Funda; Taşkapan, Hülya; Sigirci, Ahmet; Akpınar, Mehmet Beşir

doi:10.5152/etd.2016.0052

Cited by 5 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Screening for anticoagulant factors which can predispose a person to hypercoagulability is highly recommended in patients undergoing hemodialysis and are potential candidate for renal transplant as a precautionary measure to decrease the risk of subsequent graft rejection. 17 From literature review we see that the PC & PS deficiencies are more common as well as stronger risk factors for thromboembolism as compared to antithrombin and factor V mutation and may be helpful in forecasting the risk of thromboembolism in Asians. 18,19 In our study we found 6.66% patients had PC deficiency and 4.0% had PS deficiency.…”

Section: Discussion Discussionmentioning

confidence: 99%

Inherited Protein C and Protein S Deficiency in Renal Transplant Candidates of Sindh Province, Pakistan

Mengal

Abbas

Aamir

et al. 2019

GJMS

View full text Add to dashboard Cite

Background: Thrombophilia is a common risk factor for venous thromboembolism. The objective of this study was to determine prevalence of inherited protein C and protein S deficiency in renal transplant candidates of Sindh Province, Pakistan. Material & Methods: This cross-sectional study was conducted in Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan from 16-10-2010 to 15-4-2011. 300 renal transplant candidates were selected. Candidates with acquired thrombotic disorders, women taking oral contraceptives and patients taking anti-coagulants during previous one week were excluded. Venous blood samples were collected before starting dialysis procedure or at least two days after last dialysis session. Platelet-poor plasma (PPP) was parted using plastic pipettes and protein C and protein S were processed on coagulation analyzer. Sex, age groups (<40 and ≥ 40years), presence of protein C deficiency and presence of protein S deficiency were nominal variables and analyzed by count and percentage along with population parameters. Results: 300 renal transplant candidates included 199 (66.33%) men and 101 (33.67%) women and 238 (79.33%) in age group <40 years and 62 (20.67%) cases in age group ≥40 years. Prevalence of protein C deficiency was 6.66% (20/300) and of protein S deficiency was 4% (12/300). Prevalence of PC deficiency was higher in men 5.33% than women 1.33%. Also prevalence of PS deficiency was higher in men 3.0% than women 1.0%. Prevalence of PC deficiency was higher in age group <40 years 5.67% than ≥40 years 1.0%. Also prevalence of PS deficiency was higher in age group <40 years 3.33% than ≥40 years 0.66%. Conclusion: More prolonged and follow-up studies are needed to define the true significance of deficiency of protein C and S (coagulation inhibitors) in post-transplant settings.

show abstract

Section: Discussion Discussionmentioning

confidence: 99%

Inherited Protein C and Protein S Deficiency in Renal Transplant Candidates of Sindh Province, Pakistan

Mengal

Abbas

Aamir

et al. 2019

GJMS

View full text Add to dashboard Cite

show abstract

“…In a 2014 study, of 338 autologous AVFs, 326 patients had obvious AVFs for dialysis (96.4% surgical success rate, or 3.6% AVF failure rate) (13). Sari et al detected AVF failure in 81 patients out of 831 studied cases (rate = 10%) (14), and Monroy-Cuadros et al reported 15.3% for incidence rates of primary AVF filure and never using AVF after operation (15).…”

Section: Discussionmentioning

confidence: 99%

“…From another perspective, performing a meta-analysis on published researches concludes many inscrutable points in different studying conditions; for example, there are conflicts on risk of BP toward AVF failure. While a study in 2016 on 36 HD patients did not find any relationship between BP and thrombosis formation (p>0.05) (14), in 2 more detailed reviews on 87 HD patients, a significant relationship was found between the systolic blood pressure (SBP) and the delay of AVF maturation (30). Moreover, under publishing research in Nature journal, which was done on 480 HD patients, indicated that the patients with a positive history of hypertension have more matured AVF (31).…”

Section: Discussionmentioning

confidence: 99%

A new method to determine anastomosis angle configuration for arteriovenous fistula maturation

Rezapour

Sepehri

Zadeh

et al. 2018

Med. J. Islam. Republic Iran

View full text Add to dashboard Cite

Background: The kidneys of patients with chronic kidney disease (CKD) do not function well enough and those in end-stage renal disease (ESRD) of CKD need hemodialysis (HD) as a common renal replacement therapy (RRT) procedure. HD requires a vascular access (VA), and arteriovenous fistula (AVF) is the common VA choice in the world due to its very few complications. Despite the widespread use of AVFs, some risk factors maximize AVF failure, which is accompanied by complications of the patient such as repeating VA surgeries and hospitalization. Therefore, finding effective factors in the success of surgery is highly important and, thus, this study aimed at measuring the effect of anastomosis angle on the success of AVF surgery. Methods: This study evaluated the effect of conducted angle in an AVF anastomosis on AVF maturation. The images of 48 created AVFs for CKD patients was provided over a one-year period (from May 2016 to April 2017). Cross-tab analysis was used, and significance level was considered meaningful at p-value≤0.001. A centralized database was designed to integrate data. A method for image processing was developed and geometrical characteristics of the vessels (such as anastomosis angle) and also the diameter of artery and vein were measured via AutoCAD 2017 software and exported to the database along with other data. Results: The rate of the AVF failure in the studied patients was 8.96%. The anastomosis angle ≤ 30° is preferable from the AVF status point of view because most AVF maturation (or least AVF failure) rates are detected at this range. Conclusion: This study was performed based on a new approach without the need to measure hemodynamic parameters. Moreover, it signified the important role of anastomosis angle in the function of AVF, showing that the anastomosis angle ≤ 30° is a preferable intraoperative recommendation for AVF surgery.

show abstract

“…Kaygin et al found no relationship between total protein and AVF maturation outcomes [24]. Also, Sari et al found no correlation between total protein level and AVF thrombosis [25].…”

Section: Serum Ironmentioning

confidence: 99%

Predicting Arteriovenous Fistula Non-Maturation in Hemodialysis Patients: Analytics of Inflammatory Markers and Serum Metabolic Values

Nakhaei

Sepehri

Shadpour

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Population aging has brought a rise in the prevalence of diabetes and hypertension, leading to more cases of renal failure. Hemodialysis, as a method of renal replacement therapy, by far prevails over peritoneal dialysis (93.5% vs. 6.5%). Although arteriovenous fistula (AVF) is frequently chosen as the vascular access route for chronic hemodialysis; it has limitations including non-maturation. As maintenance of an AVF is much more costly than its creation, foreseeing maturation failure can lead to a wiser allocation of patients to AVF surgery or other alternatives, with potential for significant cost containment.Methods We investigated the relationship of routinely available systemic inflammatory markers and baseline metabolic values in 107 end-stage renal disease patients (over 35 years of age undergoing their first brachio-cephalic AVF access surgery at wrist level for chronic hemodialysis). In this study, for the first time to our knowledge, we applied predictive analytic tools such as Random Forest for retrospective analysis of prospectively collected data between 2011 and 2018.Results Our results showed that a combination of inflammatory markers and serum metabolic values can prognosticate AVF maturation outcomes with an accuracy of 0.723, by the 95% confidence interval of (0.715, 0.731) and AUC of 0.853. Also, a combination of inflammatory markers, including albumin, c-reactive protein, erythrocyte sedimentation rate, hemoglobin, lymphocytes, neutrophils, white blood cells, platelets, and red blood cell distribution width, can prognosticate AVF maturation outcomes with an accuracy of 0.674, by the 0.95 confidence interval of (0.665, 0.684) and AUC of 0.824.Conclusion Risk stratification of patients for AVF non-maturation before attempting the first AVF surgery may help prevent multiple surgical failures and costly endovascular interventions by allowing vascular surgeons to make an individualized choice of vascular access method for new patients.

show abstract

Evaluation of Risk Factors for Arteriovenous Fistula Failure in Patients Undergoing Hemodialysis

Cited by 5 publications

References 29 publications

Inherited Protein C and Protein S Deficiency in Renal Transplant Candidates of Sindh Province, Pakistan

Inherited Protein C and Protein S Deficiency in Renal Transplant Candidates of Sindh Province, Pakistan

A new method to determine anastomosis angle configuration for arteriovenous fistula maturation

Predicting Arteriovenous Fistula Non-Maturation in Hemodialysis Patients: Analytics of Inflammatory Markers and Serum Metabolic Values

Contact Info

Product

Resources

About