Evaluation of Risk Factors for Exacerbations in Children with Adenoviral Pneumonia

Abstract

Purpose. The aim of this work was to analyze clinical features and laboratory findings of children with adenovirus pneumonia and guide clinical diagnosis, treatment, and assessment of disease severity. Material and Methods. Retrospective analysis of clinical data of 285 children with adenoviral pneumonia who were hospitalized in Wuhan Children’s Hospital from December 2018 to October 2019. According to the assessment criteria for severe pneumonia, it was divided into the severe group (92 cases) and the nonsevere group (193 cases). Collected clinical manifestations, complications, and laboratory test indicators in two groups of children and conducted all statistical analyses. Results. The risk of fever and wheezing was significantly higher in the severe group than in the nonsevere group. The difference was statistically significant (P<0.05). The risk of complications in the severe group was significantly higher than that in the nonsevere group. The difference was statistically significant (P<0.05). The levels of AST, LDH-L, PCT, ferritin, and D-dimer in the severe group were significantly higher than those in the nonsevere group. The difference was statistically significant (P<0.05). Conclusion. Children with severe adenovirus pneumonia have severe clinical manifestations and many complications. AST, LDH-L, PCT, ferritin, and D-dimer levels have important clinical implications for assessing disease severity.

Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children: a cross-sectional study in Zhejiang

“…Wheezing and shortness of breath was more frequent in the severe group. Patients with severe HAdV infections have prolonged fever and required longer hospitalization which was consistent with Wuhan report [ 30 ]. It is different in severity in HAdV infection under the age, environmental status, and immunological status of the patient.…”

Risk Factors for the Development of Hemophagocytic Lymphohistiocytosis in Children With Severe Adenovirus Pneumonia: A Single-Center Retrospective Study

“…The previous studies showed that HAdV-7 causes a more severe disease than the other serotype, with a higher intensive care unit admission rate and a longer length of hospital stay (20). The underlying mechanism may be related to a higher viral load and inflammatory response (5,21,22). In the present study, the median age of all cases was 1.50 years, with 100 cases (80.6%) younger than 3 years old.…”

Based on the Auxiliary Effect of X-Ray in the Treatment of Severe Pneumonia in Children with Arterial and Venous Blood Gas

“…In fact, imaging examinations are widely used. A common belief is that patients with suspected pneumonia should undergo chest X-ray examination once they are admitted to the hospital [ 12 , 13 ]. Sometimes sputum microscopy and sputum culture are also performed to understand the types of pathogenic bacteria to assist in the diagnosis and treatment of some complex and refractory cases.…”