Evaluation of role of cytodiagnostic techniques in detection of oral premalignant and malignant lesions: Study of 50 cases

Bhandari, Anup Pravin; Gadkari, Rasika

doi:10.4103/2231-6027.171155

Cited by 5 publications

(10 citation statements)

References 1 publication

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“…Owing to its high NPV and accuracy, it can be used as a noninvasive diagnostic modality for OPMD and early OSCC. Exfoliative cytology when performed properly is the most accurate adjunctive technique which detects early malignant changes like dysplasia and also shows strong correlation with histopathology as shown in previous studies with a high degree of sensitivity and specificity (Remmerbach et al, 2001;Driemel et al, 2008;Mehrotra et al, 2008;Babshet et al, 2011;Jha et al, 2014;Bhandari et al, 2015;Salih et al, 2017).…”

Section: Discussionmentioning

confidence: 78%

Evaluation of Role of Visual Inspection Using Acetic Acid (VIA) and Exfoliative Cytology in Screening and Early Detection of Oral Premalignant Lesions and Oral Cancer

Singh

Varma

Bhargava

et al. 2021

Asian Pac J Cancer Prev

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Objective: Oral cancer accounts for 50-70% of total cancer mortality. VIA screening has drastically changed the morbidity and mortality related to cervical cancer. In present study, we assessed the role of 5% Acetic Acid as a vital stain in oral mucosa of chronic tobacco chewers, to know if it can help in early diagnosis and improved prognosis of oral malignancies and to assess the sensitivity and specificity of VIA and exfoliative cytology for screening of Oral premalignant and malignant lesions in high risk population with limited health care infrastructure. Methods: This was an outpatient department based prospective study done in a tertiary hospital over a period of two years. 150 cases with a history of chronic tobacco use were evaluated. Visual inspection (VI) followed by VIA using 5% Acetic acid was done. Oral scrapes were taken for cytological examination followed by biopsy for histopathological evaluation, wherever possible. Results: Sensitivity, specificity, PPV, NPV and accuracy of VIA and Exfoliative cytology was 71%, 65%, 83%, 48%, 69% and 98%, 65%, 89%, 92%, 88% respectively keeping histology as gold standard. Conclusion: Acetic acid along with exfoliative cytology can be used as simple, cost effective and convenient methods for mass screening of OPMDs and OSCC in high risk population where biopsy is not possible.

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Section: Discussionmentioning

confidence: 78%

Evaluation of Role of Visual Inspection Using Acetic Acid (VIA) and Exfoliative Cytology in Screening and Early Detection of Oral Premalignant Lesions and Oral Cancer

Singh

Varma

Bhargava

et al. 2021

Asian Pac J Cancer Prev

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“…LBC and its modified versions, such as centrifuged LBC, have been successfully utilized to improve the diagnostic accuracy and are advantageous in the reduction of screening time. However, LBC requires expensive automated devices and materials that might not be affordable by many cytopathological laboratories with limited resources [14]. A modified technique of centrifuged LBC, called sediment cytology, involves the study of smears prepared from the sediment of the biopsy specimen fixative.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Efficacy of Sediment Cytology over Oral Brush Cytology in Oral Leukoplakia

et al. 2019

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Introduction: A method called sediment cytology includes the investigation of smears arranged from the sediment of the biopsy specimen fixatives. The sediment from this fixative is used to prepare smears and provides a potentially rich source for cytological material. Investigation of the fixative sediment and understanding of the cytological picture with pertinent clinical and radiological information permits diagnosis in a few hours. Aim: To evaluate the diagnostic efficacy of sediment cytology and oral brush cytology compared with histopathological findings in oral leukoplakia (OL) cases. Methods: Cytological smears were obtained from 30 clinically diagnosed OL lesions using 2 techniques: oral cytobrush and 10% formalin fixative sedimentation. Both smears were stained with Papanicolaou. Cytological smear evaluation was conducted with respect to cellularity, cell distribution, cellular clumping, and the presence of blood, debris, inflammatory cells, and microbial colonies. The cytopathological scores for all cases were compared between sediment and brush cytology and correlated with the histopathological diagnosis. For statistical analysis, the κ test and the Wilcoxon matched-pair test were used. Results: The cytobrush technique had a sensitivity of 83.3% for OL cases histopathologically diagnosed as severe dysplasia, while the sediment cytology technique had a sensitivity of 16.6%. For moderate/mild dysplasia cases, the cytobrush technique had a sensitivity of 7.7%, whereas the sediment technique showed no diagnostic sensitivity. Conclusion: Based on the results from the present study, sediment cytology, unlike oral brush cytology, is not a useful screening tool for the preliminary diagnosis of potentially malignant oral lesions.

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“…[ 1 ] Oral cancer constitutes the sixth most common malignancy in the world. [ 2 ] Oral potentially malignant disorders (OPMDs) are clinical presentations that carry a risk of cancer development in the oral cavity, whether in a clinically definable precursor lesion or clinically normal mucosa. [ 3 ] Despite significant advances in the treatment of cancer, early detection of oral cancers and their curable precursors remain the best approach to ensure patient survival, improved quality of life, reduced mortality, and public health costs.…”

Section: Introductionmentioning

confidence: 99%

“…[ 4 ] Though histopathology is considered the gold standard, cytology has been widely accepted as a tool in the early diagnosis of cancer. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 5 ] Many studies have been conducted on techniques such as brush cytology or scrape cytology in the diagnosis of oral cavity lesions. [ 1 2 5 6 ] In recent times, studies have been conducted on the utility of liquid-based cytology techniques using various processing solutions with different compositions. [ 4 7 8 9 10 11 12 ] The present study highlights the utility of only normal saline as a simple and feasible processing fluid for the cytological evaluation of oral cavity lesions.…”

Section: Introductionmentioning

confidence: 99%

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Utility of Indigenous Cytology Technique in the Diagnosis of Oral Cavity Lesions using Normal Saline as a Processing Fluid: A Comparative Study

Kumarguru,

Narayana,

Urvashi

et al. 2023

Journal of Cytology

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Background: Oral cancer is a major health problem in developing countries. Cytology has been widely accepted as a tool in the early diagnosis of cancer. Objectives: To evaluate the diagnostic utility of four different cytology techniques, that is, modified brush cytology (BR) technique, brush cytology cytocentrifugation (BRCC) technique, modified scrape cytology (SR) technique, and scrape cytology cytocentrifugation (SRCC) technique and correlate the cytopathological diagnosis with the available histopathological diagnosis. Materials and Methods: It was a prospective observational study of oral cavity lesions conducted from January 2018 to December 2018 at a rural tertiary care referral institute. Smears prepared by four different techniques, that is, BR technique, BRCC technique, SR technique and SRCC technique were evaluated using a scoring system. Normal saline was used as a processing fluid for cytocentrifugation techniques, and the cytological diagnosis was compared with an available histopathological diagnosis for concordance. Results: Twenty-seven cases of oral cavity lesions were analyzed. Squamous cell carcinoma (55.56%) constituted the most common lesion diagnosed by cytology. Total concordance was 95.65%. Brush cytology techniques were better technique than scrape cytology techniques. Cytocentrifugation techniques were better than modified brush cytology technique and modified scrape cytology technique and the values were statistically highly significant ( P <0.0001). Conclusion: The utility of only normal saline as a processing fluid for cytocentrifugation may be considered an unexplored and prudent endeavor. This indigenously designed technique may be employed to improve the quality of cytological preparation for the evaluation of oral cavity lesions.

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Evaluation of role of cytodiagnostic techniques in detection of oral premalignant and malignant lesions: Study of 50 cases

Cited by 5 publications

References 1 publication

Evaluation of Role of Visual Inspection Using Acetic Acid (VIA) and Exfoliative Cytology in Screening and Early Detection of Oral Premalignant Lesions and Oral Cancer

Evaluation of Role of Visual Inspection Using Acetic Acid (VIA) and Exfoliative Cytology in Screening and Early Detection of Oral Premalignant Lesions and Oral Cancer

Comparison of the Efficacy of Sediment Cytology over Oral Brush Cytology in Oral Leukoplakia

Utility of Indigenous Cytology Technique in the Diagnosis of Oral Cavity Lesions using Normal Saline as a Processing Fluid: A Comparative Study

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