Evaluation of Rosin Gum and Eudragit® RS PO as a Functional Film Coating Material

Abstract

Polymers are essential tools in the research and development of new therapeutic devices. The diversity and flexibility of these materials have generated high expectations in the composition of new materials with extraordinary abilities, especially in the design of new systems for the modified release of pharmaceutically active ingredients. The natural polymer rosin features moisture protection and pH-dependent behavior (i.e., it is sensitive to pH > 7.0), suggesting its possible use in pharmaceutical systems. The synthetic polymer Eudragit® RS PO is a low-permeability material, the disintegration of which depends on the time of residence in the gastrointestinal tract. The present study developed a polymeric material with desirable physicochemical characteristics and synergistic effects that resulted from the inherent properties of the associated polymers. Isolated films were obtained by solvent evaporation and subjected to a water vapor transmission test, scanning electron microscopy, calorimetry, Fourier transform-infrared (FT-IR) spectroscopy, micro-Raman spectroscopy, and mechanical analysis. The new polymeric material was macroscopically continuous and homogeneous, was appropriately flexible, had low water permeability, was vulnerable in alkaline environments, and was thermally stable, maintaining an unchanged structure up to temperatures of ∼400°C. The new material also presented potentially suitable characteristics for application in film coatings for oral solids, suggesting that it is capable of carrying therapeutic substances to distal regions of the gastrointestinal tract. These findings indicate that this new material may be added to the list of functional excipients.

Polyethylene oxide biofilms incorporated into Plantago major extract as dressings for dermal lesion

“…There were no statistically significant differences (p<0.05) between the water vapor transmission rate of the control film and the film containing extract. Both presented a high WVT when compared with pullulan-polymethacrylate films (LIMA et al 2013), Eudragit ® FS 30 D (JUNGES et al 2021), and Eudragit ® RS PO associated with gum-resin (POMIN et al 2017), using the same method of analysis. The high hydrophilicity characteristic of polyethylene oxide was a determining factor for this high rate of water vapor transmission and was not affected by the addition of the extract.…”

Advances in Rosin-Based Chemicals: The Latest Recipes, Applications and Future Trends

“…In recent studies unmodified rosin was used for making films, coatings and adhesives [26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42], biomedical applications [43,44,45,46,47,48,49,50,51,52,53,54,55], or in mining, metallurgy and construction [56,57,58] and for filler purposes [59,60,61,62,63,64]. However, chemical modification of rosin gives many-fold greater possibilities of using this raw material, which are described in the next, main section of this article.…”