Evaluation of rosmarinic acid against myocardial infarction in maternally separated rats

Verma, Himanshu; Bhattacharjee, Anindita; Shivavedi, Naveen; Nayak, Prasant

doi:10.1007/s00210-022-02273-9

Cited by 3 publications

(1 citation statement)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rosmarinic acid has been reported to reduce plasma corticosterone levels and increase the expression of hippocampal mineralocorticoid receptors, glucocorticoid receptors and brain-derived neurotrophic factor in the hippocampus of rats induced with HIV-1 viral protein tat injection and subsequent repetitive restrain stress [ 38 ]. Rosmarinic acid has also been reported to reduce maternal stress induced corticosterone increase [ 39 ], chronic unpredictable stress induced increase in corticosterone [ 40 ] and reverse stress induced changes of SUV39H1, Mkp-1, and BDNF expression in the mice hippocampus [ 41 ]. Luteolin-7-O-glucuronide, another constituent of OBC, has been found to reduce blood corticosterone in a mouse sleep deprivation model, wherein the compound improved depression-like and stress coping behaviours [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic–pituitary–adrenal (HPA) axis in modulating stress

Murugan

Bethapudi

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress potential of Ocimum tenuiflorum but with higher doses. The present study investigated the effects of HolixerTM (a clinically studied standardized Ocimum tenuiflorum extract) on modulating stress using two in vivo models, namely the swim endurance study in mice and forced swim test in rats. In addition, we explored the mechanism of action of HolixerTM on the HPA axis using two in vitro cell-based assays to check for its inhibitory effect on cortisol release and CRF1 receptor antagonistic activity. Ocimum tenuiflorum extract enhanced the swimming time in mice, reduced the stress-induced increase in immobility time, and prevented the increase in corticosterone in rats subjected to the forced swim test. Further, Ocimum tenuiflorum extract inhibited cortisol release and exhibited a significant CRF1 receptor antagonist activity. Thus, Ocimum tenuiflorum extract was found effective in managing stress, and the effect could be due to the inhibition of cortisol release and the antagonistic effect on the CRF1 receptors.

show abstract