Evaluation of Safety and Effectiveness of the Paragonix™ SherpaPak Cardiac Transport System in Donation After Circulatory Death Heart Transplantation (clinicaltrials.gov Identifier: Nct05038943)

Urban, Marian; Castleberry, Anthony W.; Lowes, Brian D.; Moody, Morgan; Fristo, L.; Siddique, Aleem; Um, J.

doi:10.1016/j.healun.2022.01.1202

Cited by 2 publications

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“…22 The heart is then arrested with cardioplegia and transported using either cold static storage, the Paragonix SherpaPak Cardiac Transport System or normothermic storage. 34–36…”

Section: Dcd-heart Transplant: Procurement Methods and Perfusion Stra...mentioning

confidence: 99%

Donation After Circulatory Death Heart Transplant: Current State and Future Directions

Kharawala,

Nagraj,

Seo

et al. 2024

Circ: Heart Failure

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Orthotopic heart transplant is the gold standard therapeutic intervention for patients with end-stage heart failure. Conventionally, heart transplant has relied on donation after brain death for organ recovery. Donation after circulatory death (DCD) is the donation of the heart after confirming that circulatory function has irreversibly ceased. DCD-orthotopic heart transplant differs from donation after brain death-orthotopic heart transplant in ways that carry implications for widespread adoption, including differences in organ recovery, storage and ethical considerations surrounding normothermic regional perfusion with DCD. Despite these differences, DCD has shown promising early outcomes, augmenting the donor pool and allowing more individuals to benefit from orthotopic heart transplant. This review aims to present the current state and future trajectory of DCD-heart transplant, examine key differences between DCD and donation after brain death, including clinical experiences and innovations in methodologies, and address the ongoing ethical challenges surrounding the new frontier in heart transplant with DCD donors.

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“…22 The heart is then arrested with cardioplegia and transported using either cold static storage, the Paragonix SherpaPak Cardiac Transport System or normothermic storage. 34–36…”

Section: Dcd-heart Transplant: Procurement Methods and Perfusion Stra...mentioning

confidence: 99%

Donation After Circulatory Death Heart Transplant: Current State and Future Directions

Kharawala,

Nagraj,

Seo

et al. 2024

Circ: Heart Failure

View full text Add to dashboard Cite

show abstract

“…We do not have data on long-term outcomes, although it is hard to imagine the lower rate of PGD and comparable 1-year survival would lead to worse outcomes over a longer time frame. This remains a relatively new technology, and refinements to improve temperature control 14 and use in other settings, such as thoracoabdominal normothermic regional perfusion 15 are evolving.…”

mentioning

confidence: 99%

Coolers Are for Heinekens, Not Hearts

Eckman,

Lodewyks

2023

ASAIO Journal

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Evaluation of Safety and Effectiveness of the Paragonix™ SherpaPak Cardiac Transport System in Donation After Circulatory Death Heart Transplantation (clinicaltrials.gov Identifier: Nct05038943)

Cited by 2 publications

References 0 publications

Donation After Circulatory Death Heart Transplant: Current State and Future Directions

Donation After Circulatory Death Heart Transplant: Current State and Future Directions

Coolers Are for Heinekens, Not Hearts

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