Evaluation of safety and efficacy of Unani Add-on regimen in preventing the progression of severity of the disease in hospitalized SARS-CoV2 tested positive asymptomatic /mild to moderate symptomatic COVID-19 cases- A Randomised Controlled Clinical Trial

Khan, Asim Ali; Akhtar, Naseem; Parveen, Naheed; Kumar, Pradeep; Javed, Ghazala; Kumar, Pawan; Meena, Rampratap; Akhtar, Jamal; Anjum, Nighat; Akram, Usama; Saleem, Nauman; Nazli, Tamanna; Rej, Anirban; Mumtaz, Shoeb

doi:10.3329/bjms.v21i4.60290

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…We found that patients who received combination therapy (add-on Unani treatment along with standard treatment) in the intervention arm got early discharge and spent comparatively lesser days in the hospital in contrast to the control arm. Decreased length of stay has been associated with decreased risks of iatrogenic infections, fewer side effects of medication, and reduced unnecessary burden of medical cost on patients, and also helps reduce the patient load on the already overwhelmed health care system, as was observed during the second wave of the pandemic in India [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…The addition Siddha formulations with the standard treatment exhibit early clinical recovery without further progression in mild to moderate COVID-19 cases [ 30 ]. A similar study with Unani formulations having similar decoction ( Joshanda ) as an add-on with standard treatment showed accelerated recovery for COVID-19 patients compared to the standard Group [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of the Unani Regimen as an Add-On to Standard Treatment in Hospitalised RT-PCR-Confirmed Mild to Moderate COVID-19 Patients: An Open-Label Randomized Controlled Trial

Kishore¹,

Kumar²,

Nazli³

et al. 2023

Cureus

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Background The coronavirus disease 2019 (COVID-19) pandemic resulted in mortality and morbidity worldwide. Many treatment modalities have been experimented with limited success. Therefore, the traditional system of medicine needs to be explored. Objective To evaluate the benefits of Unani regimens Tiryaq-e-Arba and Unani Joshanda, as adjuvant therapy, were compared to standard treatment alone among reverse transcription polymerase chain reaction (RT-PCR)-confirmed mild to moderate COVID-19 cases. Materials and methods An open-label, double-arm, randomized, controlled interventional clinical study was conducted among 90 RT-PCR-confirmed mild to moderate COVID-19 inpatients admitted to a tertiary care hospital in New Delhi, India. Participants who fulfilled the criteria for inclusion were randomly assigned to two arms, with 43 subjects allocated to the Unani add-on arm and 47 subjects to the control arm receiving standard treatment alone. Results Clinical recovery was achieved in all patients of the Unani arm, while in the control arm, three (6.4%) patients deteriorated and had to be shifted to ICU following admission. In the intervention arm, a shorter duration of hospitalization was observed (mean 5.95 days {SD = 1.99}) than in the control arm (mean 7.62 days {SD, 4.06}); which was a statistically significant difference (p-value 0.017). The majority of the patients recovered within 10 days in the Unani add-on arm. The number of days taken for the reduction of symptoms was significantly less in the intervention arm (mean 5.14 days {SD, 2.39}) as compared with standard treatment (mean 6.53 days {SD, 3.06}) (p < 0.02). Renal and liver safety parameters were within the normal limits in both arms and no serious adverse event was reported. Conclusion Adding Unani formulations to standard treatment significantly reduced the duration of hospital stay and showed early recovery in COVID-19 patients compared with the control arm. It may be concluded that the synergistic effect of the Unani add-on with standard treatment gave more promising results in mild to moderate COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of the Unani Regimen as an Add-On to Standard Treatment in Hospitalised RT-PCR-Confirmed Mild to Moderate COVID-19 Patients: An Open-Label Randomized Controlled Trial

Kishore¹,

Kumar²,

Nazli³

et al. 2023

Cureus

Self Cite

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“…The use of these medicines has beneficial effects in improving the immunity of an individual as well as early recovery of mild to moderate COVID-19 confirmed cases. 10,12 India is considered to be the third world's worst-affected country in the COVID-19 pandemic. Sudden lockdown isolation, curfew, social distancing, and precautionary measures had strongly impacted people's life by affecting their lifestyle, eating habits, sleep routine, and physical activity.…”

Section: Increase In Traditional Medicine and Other Supplementationmentioning

confidence: 99%

Changes in Lifestyle, Food Choices, Sleeping Habits, and Physical Activities during the COVID-19 Pandemic: Analysis of Data after the First Lockdown Period from Three States of India

Nazli

2022

EpidemInt

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Background: The COVID-19 pandemic led to a substantial influence on the lifestyle of individuals. This article focuses to investigate the changes in lifestyle behaviour, food choice, sleeping habit, and physical activities that occurred during the COVID-19 pandemic. Method: A cross-sectional study was conducted and data were captured through a web-based application questionnaire using a convenience sample method among individuals visiting health camps under the mobile healthcare programme conducted by three peripheral institutes of Central Council for Research of Unani Medicine in identified pockets of three different states in India to assess the impact of the COVID-19 induced lockdown on changes in their lifestyle, food preferences, physical activity, and social life among the population. Results: The data were obtained from 1007 cases in total between the age group of 15 and 90 years. The lockdown resulted in an alteration in the lifestyle as manifested by a change in food choices (65.4%), a change in sleeping routine (65.1%), a reduction in physical activity (63.7%), and a change in social life (68.9%) of the participants. A notably increased use of traditional medicine and herbal preparations has been reported by the study participants during the lockdown. Conclusions: Isolation, fear, distress, and social stigma caused various lifestyle changes and psychological problems among people during the first lockdown.

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Evaluation of safety and efficacy of Unani Add-on regimen in preventing the progression of severity of the disease in hospitalized SARS-CoV2 tested positive asymptomatic /mild to moderate symptomatic COVID-19 cases- A Randomised Controlled Clinical Trial

Cited by 2 publications

References 8 publications

Efficacy of the Unani Regimen as an Add-On to Standard Treatment in Hospitalised RT-PCR-Confirmed Mild to Moderate COVID-19 Patients: An Open-Label Randomized Controlled Trial

Efficacy of the Unani Regimen as an Add-On to Standard Treatment in Hospitalised RT-PCR-Confirmed Mild to Moderate COVID-19 Patients: An Open-Label Randomized Controlled Trial

Changes in Lifestyle, Food Choices, Sleeping Habits, and Physical Activities during the COVID-19 Pandemic: Analysis of Data after the First Lockdown Period from Three States of India

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