The rate of occupational accidents is increasing, leading to a number of organizational deficiencies. For European Union (EU), the non-fatal accident number in 2017 was 3,315,101. An increase in the number of accidents is recorded in many of the member states. In addition, the increase in accidents tends to focus on certain sectors and is due more to the increase in the incidence rate than the increase in the workforce. Companies in these industry sectors have also implemented less intensive prevention practices than firms in other sectors. Performing a statistical evaluation of non-fatal and fatal accidents is an important one. This assessment helps managers understand the importance of implementing prevention and control methods across organizations. For this research, we used series of data obtained from the Romanian National Institute of Statistics (NIS), Labor Inspection in Romania, and Eurostatof the European Commission. Data series evaluations were conducted for the EU and Romania. A qualitative assessment of the industry data series had been carried out. Furthermore, T-tests and analysis of variance analysis (ANOVA) were performed to identify the relationships between the frequency index of fatal and non-fatal accidents, and the categories chosen. The values obtained for men were significantly higher than those of female workers. Based on the results of the qualitative assessment and European and national strategies, an experimental model for the prevention and control of occupational accidents is proposed. At the end of the paper, the situation of labor accidents in Romania and Bulgaria, two EU member states, is assessed in the agriculture, forestry and fishing, manufacturing, construction and transport, and storage sectors. A series of trends are presented for the period 2018–2020. The results obtained from the evaluation of the data series represent an important core of the Romanian Labor Inspectorate for the development of strategic actions.