Evaluation of salivary adiponectin profile in obese patients

Nigro, Ersilia; Piombino, Paola; Scudiero, Olga; Monaco, Maria Ludovica; Schettino, Pietro; Daniele, Aurora

doi:10.1016/j.peptides.2014.11.007

Cited by 28 publications

(32 citation statements)

References 32 publications

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“…While serum adiponectin has consistently been associated with BMI and obesity (Lihn et al, 2005), the link between salivary adiponectin and BMI is not as well supported (Mamali et al, 2012;Nigro et al, 2015). The overall health and narrow range of BMI in our sample may have made it more difficult to see an adiponectin-BMI association.…”

Section: Serum and Saliva Adiponectin And Associations With Age Sex mentioning

confidence: 66%

“…Studies suggest that the primary species of adiponectin in oral fluid is even more complex, a super HMW oligomer (Nigro et al, 2015). Antibodies in the adiponectin assays may not necessarily recognize each species with the same affinity and may differ in avidity effects with the various complexes of adiponectin.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…The relationship between protein levels in oral fluids and plasma makes oral fluid an attractive biospecimen that could be used as an alternative to blood in tests measuring adiponectin. Many studies suggest that the measurement of adiponectin in saliva by immunoassay is feasible, minimally-invasive, and may be an acceptable alternative to plasma sampling (Desai & Mathews, 2014;Nigro et al, 2015). However, more research on the relationship between adiponectin levels in serum and saliva is needed as some studies report low levels of correspondence in serum and saliva (Mamali et al, 2012;Thanakun, Watanabe, Thaweboon, & Izumi, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Adiponectin: Serum-saliva associations and relations with oral and systemic markers of inflammation

Riis

Bryce

et al. 2017

Peptides

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This study addresses gaps in our understanding about the validity and utility of using salivary adiponectin to index serum adiponectin levels. Matched blood and saliva samples were collected on a single occasion from healthy adults (n= 99; age 18-36 years, 53% male). Serum and saliva was assayed for adiponectin and inflammatory cytokines (IL-1β, IL-6, IL-8, TNFα), and saliva was also assayed for markers of blood contamination (transferrin), total protein (salivary flow rate) and matrix metalloproteinase-8 (MMP-8). We examined the extent to which salivary adiponectin was associated with serum adiponectin, and the influence of potential confounders on the serum-saliva correlation, including age, sex, body mass index, and markers of inflammation, oral health, salivary blood contamination, and flow rate. Findings revealed a modest serum-saliva association for adiponectin, and strong positive associations between salivary adiponectin and salivary levels of inflammatory cytokines, MMP-8, transferrin, and total protein. By contrast, salivary adiponectin was not related to serum levels of inflammatory activity. The magnitude of the serum-saliva association was strengthened when controlling for total protein in saliva, blood leakage into oral fluid, salivary inflammatory cytokines, and MMP-8. The pattern of findings extends our understanding of salivary adiponectin and its potential use as an index of circulating adiponectin levels.

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Section: Serum and Saliva Adiponectin And Associations With Age Sex mentioning

confidence: 66%

Section: Strengths and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin: Serum-saliva associations and relations with oral and systemic markers of inflammation

Riis

Bryce

et al. 2017

Peptides

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“…Ten articles included only children and adolescents, 21,23,34,35,43,44,51,53,54,56 whereas 21 included only adults. 22,[24][25][26]33,36,37,[39][40][41][42]45,[47][48][49][50]55,[57][58][59]61 Three articles included children, adolescents, and adults. 38,46,52 Among the 34 included articles, 18 different adipokines were analyzed.…”

Section: Study Characteristicsmentioning

confidence: 99%

Association between obesity and adipokines levels in saliva and gingival crevicular fluid: A systematic review and meta‐analysis

Duffles

Hermont

Abreu

et al. 2019

J Evidence Based Medicine

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Aim This systematic review and meta‐analysis aimed to compare adipokines’ levels in gingival crevicular fluid (GCF) and saliva between individuals with obesity and individuals without obesity. Methods Computerized searches were conducted in four electronic databases (PubMed, Medline via Ovid, Web of Science, and Scopus). Manual searches and a Google Scholar search, limiting the search to the first 100 hits, were also conducted. Two calibrated authors performed the study selection, data extraction, and quality assessment of included articles. The quality of the included articles was evaluated using the University of Adelaide Tool. Results The electronic searches retrieved 929 titles/abstracts. Following the removal of duplicated references, 613 titles/abstracts were assessed. Thirty‐four articles were included. Meta‐analysis demonstrated that tumor necrosis factor‐α (TNF‐α) concentration in saliva was statistically increased in individuals with obesity compared with individuals without obesity (P < 0.05). By contrast, the meta‐analysis showed no difference in the concentrations of resistin, adiponectin, leptin, ghrelin, and interleukin 6 in saliva and of resistin, adiponectin, leptin, interleukin 6, interleukin 8, tumor necrosis factor α, and plasminogen activator inhibitor 1 in GCF between individuals with and without obesity (P > 0.05). Conclusions Individuals with obesity presented higher levels of TNF‐α in saliva than individuals without obesity. TNF‐α in saliva sampling may be a helpful marker for obesity. For the other adipokines, no difference was observed, but the limited availability and heterogeneity of data do not allow us to assertively state whether changes of adipokines in GCF and saliva are associated with obesity.

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“…Dentobacterial plaque on oral mucosa and tongue was removed with a new toothbrush. Afterwards, teeth were rinsed with purified water for 60 seconds to eliminate any remnant . Prior to collecting saliva, schoolchildren rinsed their mouths with cold purified water and instructed them to chew sterile gauze for 60 seconds that was placed in the oral cavity with a sterile Hu‐friedy dental healing clamp (Hu‐friedy Mfg.…”

Section: Subjectsmentioning

confidence: 99%