Evaluation of Saraca indica for the management of dexamethasone-induced osteoporosis

Thakur, Ruchi Singh; Pawar, Rajesh Singh; Ahirwar, Bharti

doi:10.1016/j.jacme.2015.09.007

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…The efficacy of CQ fortified rice/flour to treat calcium deficiency-associated diseases was studied in albino Wistar rats. Animals were randomly divided into nine groups, and the OP test groups (Group 2 to 5) received intramuscular injection of dexamethasone sodium phosphate (7 mg/kg) once a week up to 4 weeks for the induction of OP (Lucinda et al, 2010;Thakur et al, 2016). Likewise, the OA test groups (Group 6 to 9) are induced with an infrapatellar injection of mono-iodoacetate into the right knee joint (10 mg/ml) (Janusz et al, 2001).…”

Section: Experimental Designmentioning

confidence: 99%

Fortification of raw rice and rice flour using Cissus quadrangularis L. (veldt grape) stem powder to overcome osteoporosis and its associated skeletal complication through staple diet

et al. 2021

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This study aimed to prepare the fortified rice/flour with Cissus quadrangularis (CQ) stem powder to eliminate nutritional deficiency and improve bone health. Mineral analysis by atomic absorption spectroscopy revealed that the CQ stem has adequate quantities of calcium, magnesium, and a moderate amount of phosphorous to meet the Recommended Dietary Allowance (RDA). Thus, the rice and flour were fortified with freeze-dried CQ stem powder to improve its nutraceutical contents. The fortification was done using standard vacuum impregnation and blending process. Furthermore, the recuperative activity of prepared fortified rice (CQFR) and flour (CQFF) was tested in chemically induced osteoporosis and osteoarthritis animal models. The efficiency of CQ fortified diet against these complications was confirmed by hematology, radiology, and histopathological analysis. The rat groups fed with CQFF/CQFR diet showed significant improvement from calcium deficiency and its allied physiological damage.Thus, this study confirms that the CQ fortified rice would provide recovery from skeletal complications associated with calcium deficiency through fixing both homeostasis and bio-accessibility of the calcium.

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Section: Experimental Designmentioning

confidence: 99%

Fortification of raw rice and rice flour using Cissus quadrangularis L. (veldt grape) stem powder to overcome osteoporosis and its associated skeletal complication through staple diet

et al. 2021

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“…Group III rats received intramuscular injections of 7 mg/kg of dexamethasone (Decadron, 4 mg/mL, Eipico Egypt) once a week for 10 weeks. [14][15][16] Scarification of all the animals was carried out with ketamine overdose, and the mandibles were dissected. We subjected the right side of each mandible for light microscopic examination, while the left sides of the mandibles were used for scanning electron microscopic (SEM) examination as well as analysis of the constituent element (calcium concentration) using an energy dispersive radiography unit attached to the SEM.…”

Section: Animal Experimentalmentioning

confidence: 99%

Hazards of Short- and Long-term Administration of Glucocorticoids on the Periodontium in Rats: A Histological and Electron Microscopic Study

Hagag¹,

Fathy²,

Mahmoud³

et al. 2019

J Dent Indones

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The administration of glucocorticoids is proven to cause serious adverse events. Objectives: This study was conducted to compare the possible hazards of the short-and long-term administration of glucocorticoids on the periodontium in rats, using histological examination and scanning electron microscopy. Methods: Fifteen adult male albino rats were included in the study and divided into the 3 groups. Group I served as a control, group II received 7 mg/kg dexamethasone intramuscularly once a week for 5 wk, and group III received 7 mg/kg dexamethasone intramuscularly once a week for 10 wk. The mandibles were dissected and examined histologically as well as with scanning electron microscopy and energy dispersive radiography. Results: Histologically, group I showed normal an alveolar process. In group II, bone trabeculae demonstrated obvious Howship's lacunae of osteoclasts. In group III, bone trabeculae exhibited multiple degenerated osteocytes with apparent vacuolization. Scanning electron microscopy revealed smooth alveolar bone architecture in group I. Groups II and III demonstrated irregular bone architecture with widening of the neurovascular canals. EDX analysis demonstrated the highest calcium-phosphorous concentration in the control group and the lowest in group III. Conclusions: Dexamethasone has a devastating impact on the alveolar bone via the acceleration of bone resorption and decreased activity of osteoblasts. This effect was more pronounced with prolonged drug administration.How to cite this article: Hagag TAEK, Fathy E, Mahmoud MF, Salem Z. Hazards of short-and long-term administration of glucocorticoids on the periodontium in rats: a histological and electron microscopic study. J Dent Indones. 2019;26(3):145-152.

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“…9 However, they suffer from several drawbacks, such as (i) significant variability that renders these tests noninterchangeable; (ii) lower analytical and/or clinical performances; (iii) higher cost than the high-throughput devices used in central laboratories; (iv) lack of appropriate training for staff performing the tests (with risk of errors in the analytical phase); (v) absence of systematic verification of preanalytical errors such as hemolysis, contamination from infusion fluids; (vi) necessity of predefined algorithms with decision-making thresholds; (vii) most of the POC devices increase the environmental burden as they are manufactured from unsustainable polymeric materials like thermoplastic and elastomers. 10 11 12 Taken together, POCT is one possibility to reduce the total TAT after interdisciplinary risk/benefit analysis and definition of an appropriate quality control program, regular staff training and documentation (e.g., by connecting devices to the Hospital or Laboratory information systems). 11…”

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confidence: 99%

Hemostasis Testing in the Emergency Department: A Narrative Review

Thonon,

Van Nieuwenhove,

Thachil

et al. 2024

Semin Thromb Hemost

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Routine laboratory screening is typically performed at initial evaluation of the vast majority of presentations to the emergency department (ED). These laboratory results are crucial to the diagnostic process, as they may influence up to 70% of clinical decisions. However, despite the usefulness of biological assessments, many tests performed are inappropriate or of doubtful clinical relevance. This overutilization rate of laboratory testing in hospitals, which represents a significant medical–economic burden, ranges from 20 to 67%, with coagulation tests at the top of the list. While reviews frequently focus on nonintensive care units, there are few published assessments of emergency-specific interventions or guidelines/guidance to date. The aim of this review is to highlight current recommendations for hemostasis evaluation in the emergency setting with a specific analysis of common situations leading to ED admissions, such as suspected venous thrombosis or severe bleeding. We revisit the evidence related to the assessment of patient's hemostatic capacity based on comprehensive history taking and physical examination as well as best practice recommendations for blood sample collection to ensure the reliability of results. This review also includes an examination of various currently available point of care tests and a comprehensive discussion on indications, limitations, and interpretation of these tests.

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Evaluation of Saraca indica for the management of dexamethasone-induced osteoporosis

Cited by 7 publications

References 4 publications

Fortification of raw rice and rice flour using Cissus quadrangularis L. (veldt grape) stem powder to overcome osteoporosis and its associated skeletal complication through staple diet

Fortification of raw rice and rice flour using Cissus quadrangularis L. (veldt grape) stem powder to overcome osteoporosis and its associated skeletal complication through staple diet

Hazards of Short- and Long-term Administration of Glucocorticoids on the Periodontium in Rats: A Histological and Electron Microscopic Study

Hemostasis Testing in the Emergency Department: A Narrative Review

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