Evaluation of P300 components for emotion‐loaded visual event‐related potential in elderly subjects, including those with dementia

Abstract

Aim: In the present study, the P300 component of the emotion-loaded visual event-related potential in response to photographs of babies crying or smiling was measured to evaluate cognitive function in elderly subjects, including those with dementia. Methods:The subjects were 48 elderly people who consulted a memory disorder clinic. The visual eventrelated potential was measured using oddball tasks. Brain waves were recorded from four sites. We analyzed the P300 amplitude and latency. Subjects were divided into three groups (the dementia with Alzheimer's disease group [ADG] Results: For all subjects, there was a significant positive correlation between P300 latency and Z-score of voxel-based specific regional analysis for Alzheimer's disease for crying or smiling faces. There was a negative correlation between P300 amplitude and Z-score for the crying face. MG subjects were divided into two groups (high risk: HRMG, low risk: LRMG) based on Z-scores (HRMG ≥ 2.0). The P300 amplitude of ADG was significantly smaller than that of HG, and the P300 latency of ADG was significantly longer than those of other groups for crying or smiling faces. The P300 latency of HRMG was significantly longer than that of LRMG for the smiling face. Furthermore, the P300 latency for the crying face was significantly shorter than that for the smiling face in HG and ADG. Conclusion:These findings suggest that analysis of P300 components of the emotion-loaded visual event-related potential may be a useful neuropsychological index for the diagnosis of Alzheimer's disease and high-risk subjects.

On the use of the P300 as a tool for cognitive processing assessment in healthy aging: A review

“…Three studies found that patients with AD had lower amplitude of the P300 wave when compared to healthy elderly. 6 , 14 , 30 Although latency did not differ between the two groups in the study by Lee et al, 14 it was higher for elderly with AD compared to healthy elderly with high and low risk of dementia in the study of Asaumi et al (2014). 6 In addition to these investigations, another study observed better latency and amplitude values for the group without subjective memory complaints than the group with complaints.…”

“…Regarding the most evident findings, half of the articles found an influence of age on P300 values. In 19.2% of the studies, associations between neurocognitive impairment and worse electrophysiological evaluation 6 , 13 , 14 , 30 , 31 were found. Education was an item commonly not associated with P300 evaluation.…”

“…The evaluation of P300 was used in 53.8% of the articles to identify the influence of age on cognitive processing performance. 5 , 15 - 17 , 19 , 21 , 23 - 29 In 19.2% of the studies, the P300 was used to compare the electrophysiological evaluation of healthy and cognitively impaired participants, 6 , 13 , 14 , 30 , 31 15.4% used electrophysiological evaluation to monitor the effects of therapies in clinical trials, 32 - 35 one study evaluated the P300 according to age, depression, and cognition, 2 one evaluated depression in post-stroke patients 22 and one paper studied the difference between older monolingual and bilingual adults. 18 A summary of the results is given in Table 1 .…”

Human Brain Reacts to Transcranial Extraocular Light

“…With extraocular bright light delivery via both ear canals, centro-parietal P300 responds differently toward emotional distractors, indicating that the human brain reacts to extraocular light. The centro-parietal P300 has been associated with attentional resource allocation [ 45 ], with emotional stimuli able to capture attentional resources [ 19 , 23 , 46 ] and modulate centro-parietal P300 amplitude [ 41 – 43 ]. The emotional modulation of centro-parietal P300 amplitude due to emotional distractors disappeared during extra-ocular light delivery.…”

Efficacy of electrical acupuncture on vascular cognitive impairment with no dementia: study protocol for a randomized controlled trial

“…ERP provides a non-invasive way to evaluate brain function in patients with cognitive impairment by observing the typical electrophysiological response to a stimulus. In this RCT, it is the P300 component abnormalities (change of latent period and wave amplitude) that will be observed [ 19 ].…”