Evaluation of screening for hepatitis B surface antigen during pregnancy in a population with a high prevalence of hepatitis B surface antigen-positive/hepatitis B e antigen-negative carriers

Zamir, C; Dagan, Ron; Zamir, Doron; Rishpon, Shmuel; Fraser, Drora; Rimon, Nurit; E, Ben Porath

doi:10.1097/00006454-199903000-00011

Cited by 19 publications

(7 citation statements)

References 11 publications

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“…In the present study, the full-term seropositivity rate at 3 years of age was 71.8%, very similar to earlier studies of 3-year seropositivity levels in full-term Israeli [16] and American [17] infants for the same three-dose protocol. Fourdose protocols in areas endemic to hepatitis B virus yielded higher rates at 3 years, namely 87% in Taiwan [14] and 95% in Gambia [13] In contrast to children living in countries endemic to hepatitis B virus, infants in our study were assumed to have seroconverted following primary immunization because of the HBsAg-negative status of their mothers and the low incidence of hepatitis B carriers in the general Jewish Israeli population (0.5-0.6%) [18,19].…”

Section: Infection 30 · 2002 · No 3 © Urban and Vogelsupporting

confidence: 91%

Hepatitis B Vaccination: Long-Term Follow-up of the Immune Response of Preterm Infants and Comparison of Two Vaccination Protocols

et al. 2002

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Delaying vaccination of premature infants against hepatitis B until a weight of 2,000 g was reached resulted in both a significantly higher percentage of children with positive antibody levels and a significantly higher GMC at 3-3.5 years of age as compared to early-vaccinated preterm and full-term infants. The known short-term advantage of delayed vaccination of preterm infants was shown to persist for at least the first 3 years of life.

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Section: Infection 30 · 2002 · No 3 © Urban and Vogelsupporting

confidence: 91%

Hepatitis B Vaccination: Long-Term Follow-up of the Immune Response of Preterm Infants and Comparison of Two Vaccination Protocols

et al. 2002

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“…19 Zamir reported that 89% of babies from negative HBeAg carrier mothers who only received active immunization soon after birth developed protective levels of anti-HBs. 20 This study also showed that immunization coverage was high in children under five, 17/18 (94%) compared to 26/41 (64%) in children over 5 years. This may be due to mass HBV immunization in Indonesia which started in April 1997.…”

Section: Discussionsupporting

confidence: 55%

Hepatitis B serologic patterns in children of HBV carriers or infected mothers

Bisanto¹,

Chair²,

Istikowati³

2016

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Background Vertical transmission is usually the cause of increas-ing carrier rates for hepatitis B infection, especially in highly en-demic areas.Objective To determine the serologic patterns of hepatitis B inchildren of HBV carrier/infected mothers.Methods This was a cross sectional study on children of HBVcarrier/infected mothers. Subjects were recruited consecutively andexamined at the Department of Child Health, Cipto MangunkusumoHospital during January–July 2003. Children were included if theywere generally healthy and their parents gave permission. Chil-dren with chronic illness, previous blood transfusions, or drug abusewere excluded.Results Fifty-nine children of 32 HBV carrier/infected mothers wererecruited. HBsAg was positive in 8 children, anti-HBs in 37, andanti-HBc in 4 children. Seventy-three percent of children had beenvaccinated against HBV but only 81% had positive anti-HBs. Ofeighteen children who received hepatitis B vaccine and HBIg atbirth, none was infected. Six out of 25 children who received onlyhepatitis B vaccine were infected.Conclusion HBsAg, anti-HBs, and anti-HBc were positive in 14%,36%, and 7% of children of HBV carrier/infected mothers, respec-tively

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“…In our study sample, the test for immunity in infants took place over a longer time interval (between 2 and 15 months) after the final dose of vaccine, which might have reduced the proportion with protective levels. Zamir and colleagues in Israel (1999) found that 82.2% of children immunized at-birth had anti-HBs titers of ≥ 10 IU/L after 9-36 months [20]. 10% of children in our study had antibody levels < 10 IU/L and 6.5% had an undetectable antibody levels.…”

Section: Discussionsupporting

confidence: 44%

Immune and Hepatitis B virus (HBV) infection status among children receiving hepatitis B immunization in Ouagadougou, Burkina Faso

Ouédraogo

Kouanda

Tiendrébéogo

et al. 2015

J Pediatr Infect Dis

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Infection with hepatitis B is a major public health problem in Burkina Faso. The infection is transmitted through blood and sexual intercourse, as well as from mother to child during childbirth and breastfeeding. Prevention mainly involves sanitation measures and, most importantly, vaccination. This was a cross-sectional study of 200 children aged 6 to 18 months in Ouagadougou, Burkina Faso, who received three doses of a quintuple vaccine (Diphtheria, Tetanus, Pertussis, Hepatitis B, and Haemophilus influenzae type b Conjugate Vaccine Adsorbed). Post-vaccination blood samples were tested for immunity to hepatitis B (anti-HBs) and hepatitis B infection markers. Demographic data were collected using a questionnaire. The mean age of children was 9.8 ? 2.7 months, with a slight predominance of males (55%). 93.3% of children had detectable anti-HBs (? 5 IU/L) in serum, and 90% had levels considered protective (? 10 IU/L). HBsAg was found in 0.5% of children and anti-HBe and anti-HBc antibodies were found in 2.0% and 1.0% respectively. None of the children were HBeAg-positive. While the response to immunization was satisfactory, detection of HBsAg in one child does indicate that there are further opportunities to prevent mother-to-child transmission of the virus in Burkina Faso, such as vaccination at birth.

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Evaluation of screening for hepatitis B surface antigen during pregnancy in a population with a high prevalence of hepatitis B surface antigen-positive/hepatitis B e antigen-negative carriers

Abstract: Our results suggest that the Israeli vaccination program against HBV infection is effective, even in a high risk population, and additional measures are not cost-effective.

Cited by 19 publications

References 11 publications

Hepatitis B Vaccination: Long-Term Follow-up of the Immune Response of Preterm Infants and Comparison of Two Vaccination Protocols

Hepatitis B Vaccination: Long-Term Follow-up of the Immune Response of Preterm Infants and Comparison of Two Vaccination Protocols

Hepatitis B serologic patterns in children of HBV carriers or infected mothers

Immune and Hepatitis B virus (HBV) infection status among children receiving hepatitis B immunization in Ouagadougou, Burkina Faso

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