2019
DOI: 10.1111/jog.13914
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin‐6 and tumor necrosis factor‐α levels in patients with gestational diabetes mellitus

Abstract: Aim To test the hypothesis that altered A Disintegrin and Metalloproteinase Domains with Thrombospondins motifs (ADAMTS) is implicated in the etiopathogenesis of gestational diabetes mellitus (GDM). Methods All pregnant women who underwent elective amniocentesis for karyotype analysis between January 1, 2016, and January 1, 2018, were included in this study. From this cohort, the study group consisting of 20 patients diagnosed with GDM was selected and compared against a control group consisting of 20 age‐ and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
9
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 10 publications
(10 citation statements)
references
References 26 publications
1
9
0
Order By: Relevance
“…TNF-α, as another proinflammatory cytokine, has been generally identified as an important factor for the maintenance of insulin resistance, and recent studies also detect higher TNF-α concentrations in placentas and amniotic fluid of women with GDM [17,32,33]. These findings may also be supported by the fact that TNF-α levels are declining after the delivery of the placenta, which is also accompanied by a reversal of the insulin resistance [19].…”
Section: Discussionmentioning
confidence: 91%
“…TNF-α, as another proinflammatory cytokine, has been generally identified as an important factor for the maintenance of insulin resistance, and recent studies also detect higher TNF-α concentrations in placentas and amniotic fluid of women with GDM [17,32,33]. These findings may also be supported by the fact that TNF-α levels are declining after the delivery of the placenta, which is also accompanied by a reversal of the insulin resistance [19].…”
Section: Discussionmentioning
confidence: 91%
“…In the study of Zhang et al (26) on inflammation and metabolism of GDM patients in Inner Mongolia, the distribution frequency of inflammatory factors IL-6 and TNF-α in placenta in GDM women was significantly higher than that in healthy pregnant women and IL-6 was significantly correlated with GDM disease, suggesting that overexpression of these two inflammatory mediators may aggravate the progression of GDM disease by activating inflammatory cascade reaction in placenta. Other studies have shown that elevated levels of IL-6 and TNF-α in amniotic fluid of GDM patients may play an important role in the process of GDM (27). The results of this study on inflammatory factors showed that the expression of inflammatory factors IL-6 and TNF-α in SG was significantly higher than those in CG.…”
Section: Discussionmentioning
confidence: 99%
“…with great interest. 1 In this study the authors found that mean amniotic fluid IL-6 and TNF-α, disintegrin and metalloproteinase domains with thrombospon-dins motifs (ADAMTS; ADAMTS4 and ADAMTS5) levels were significantly increased in the gestational diabetes mellitus group compared with the control group.…”
mentioning
confidence: 79%