Evaluation of Selected Parameters of Oxidative Stress and Adipokine Levels in Hospitalized Older Patients with Diverse Nutritional Status

Abstract

Malnutrition is classified as one of the Giant Geriatric Syndromes. It carries serious consequences, such as sarcopenia or depression, which lead to functional disability. The main objective of this study was to identify parameters of oxidative stress and adipokines, which may be potential biomarkers of malnutrition in hospitalized older patients. During the study, selected parameters were determined in 137 senile patients, taking into account their nutritional status determined according to the Mini Nutritional Assessment (MNA), as well as an additional tool, namely the Geriatric Nutritional Risk Index (GNRI). Leptin and resistin were determined as the parameters with statistically significant differences between the patients classified according to the MNA. This phenomenon was confirmed using the GNRI classification. However, additional parameters for which differences were observed include the oxidized low-density lipoprotein level and activity of glutathione peroxidase. In conclusion, the determination of the mentioned markers in hospitalized senile patients as an adjunct to the routine assessment of nutritional status might be suggested to identify the early risk of malnutrition so that a personalized nutritional therapy can be implemented as early as possible.

Preliminary Report on the Influence of Acute Inflammation on Adiponectin Levels in Older Inpatients with Different Nutritional Status

“…Significant differences in adiponectin concentration between the group of patients with normal nutritional status and the group of malnourished patients (p = 0.004) were observed (Figure 1). In contrast, M ądra-Gackowska et al highlighted the influence of nutritional status according to the MNA on such adipokines as leptin and resistin [41]. No statistically significant differences between patients with normal nutritional status, at risk of malnutrition, and malnourished were found for APN.…”

Association between Controlling Nutritional Status (CONUT) Score and Body Composition, Inflammation and Frailty in Hospitalized Elderly Patients

“…This intricate scenario is further complicated by inflammaging, a pro-inflammatory status associated with aging and shared in numerous pathological states [ 6 , 7 ]. The altered nutritional status is also associated with increased oxidative stress, characterized by high serum levels of hydroxynonenal (HNE) and malondialdehyde (MDA) protein adducts [ 8 , 9 ]. These protein adducts are involved in several diseases, including metabolic diseases, neurodegenerative diseases, and cancer.…”