Evaluation of semen and pituitary gonadotropin function in men with untreated Hodgkin’s disease

Ragni, G.; Bestetti, O; Santoro, Armando; Viviani, Simonetta; Pietro, Roberto Di; Lauretis, L. De

doi:10.1016/s0015-0282(16)48624-3

Cited by 17 publications

(5 citation statements)

References 13 publications

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“…18,33 The FSH levels after treatment were elevated in most patients (93%), while increased levels of testosterone and LH after treatment were observed in fewer patients (57% and 21%, respectively). The median posttreatment FSH level was significantly higher compared with the median pretreatment value.…”

Section: Discussionmentioning

confidence: 99%

Fertility in male patients with advanced Hodgkin lymphoma treated with BEACOPP: a report of the German Hodgkin Study Group (GHSG)

Sieniawski

Reineke

Nogová

et al. 2008

Blood

111

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To date, there is little information on the impact of more aggressive treatment regimen such as BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) on the fertility of male patients with Hodgkin lymphoma (HL). We evaluated the impact of BEACOPP regimen on fertility status in 38 male patients with advanced-stage HL enrolled into trials of the German Hodgkin Study Group (GHSG). Before treatment, 6 (23%) patients had normozoospermia and 20 (77%) patients had dysspermia. After treatment, 34 (89%) patients had azoospermia, 4 (11%) had other dysspermia, and no patients had normozoospermia. There was no difference in azoospermia rate between patients treated with BEACOPP baseline and those given BEACOPP escalated (93% vs 87%, respectively; P > .999). After treatment, most of patients (93%) had abnormal values of follicle-stimulating hormone, whereas the number of patients with abnormal levels of testosterone and luteinizing hormone was less pro-

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Section: Discussionmentioning

confidence: 99%

Fertility in male patients with advanced Hodgkin lymphoma treated with BEACOPP: a report of the German Hodgkin Study Group (GHSG)

Sieniawski

Reineke

Nogová

et al. 2008

Blood

111

View full text Add to dashboard Cite

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“…Moreover, the spermatozoa alterations, low mean ejaculate volume and high semen pH compared with fertile men could reflect genital tractus modifications due to the disease. It is noteworthy that several authors have reported sperm alterations or high percentages of men with abnormal sperm parameters prior to cancer treatment (2,3,5,8,21,31,32). There could be several explanations for pretreatment sperm alterations: disease stage has been proposed by some authors (5,33) but not by others (8,20,31,34), as well as elevated erythrocyte sedimentation test values (5) and fever (9).…”

Section: Discussionmentioning

confidence: 99%

“…Alterations of sperm characteristics before HL and NHL treatment have been described in several studies (2)(3)(4)(5)(6)(7)(8). The causes of such alterations were not clearly identified, but there may be several risk factors for altered spermatogenesis, such as fever (9)(10)(11), stress (12,13), or inflammatory immune-mediated mechanisms (14).…”

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confidence: 99%

Impact of lymphoma treatments on spermatogenesis and sperm deoxyribonucleic acid: a multicenter prospective study from the CECOS network

Bujan

Walschaerts

Brugnon

et al. 2014

Fertility and Sterility

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“…Therefore, determining the level of FSH alone is not enough to prove recovery. [1213] In general, young men with Hodgkin's Lymphoma suffer an underlying gonadal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Study of the prevalence of azoospermia in patients with Hodgkin′s lymphoma prior to treatment

et al. 2013

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Background:Infertility is one of the main problems of patients with Hodgkin's lymphoma, as this causes specific effects in the social, family, and emotional life of patients. Hodgkin's lymphoma is a neoplastic disorder that comprises of 0.6% of all cancers and often occurs in middle-aged people, with a mean age of 26 years. It originates from neoplastic changes in the lymphoid cells, which lead to different complications in the body organs. One important complication of Hodgkin's lymphoma is humoral and cellular immune system dysfunction that can cause numerous and dangerous problems for patients. Another complication of Hodgkin's lymphoma is sterility, more specifically hypogonadism and azoospermia. Sterility may appear after treatment. Considering that most patients with Hodgkin's lymphoma have a good survival, diagnosing and treating this complication and preventing its incidence contributes to improving the quality of social life and emotional status of these patients.Materials and Methods:In this study, 238 patients whose Hodgkin's lymphoma was approved by Pathology were included in the study, before receiving any medical intervention, and they were examined for sterility (sperm status). Sterility of the male patients was confirmed using a spermogram test. The serum levels of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) were checked.Results:Among the studied patients, 24 patients (10.08%) suffered from azoospermia, which was evident in its progressive stages.Conclusion:In such cases, treatment of Hodgkin's lymphoma and improvement of the immune system could overcome azoospermia and sterility.

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Evaluation of semen and pituitary gonadotropin function in men with untreated Hodgkin’s disease

Cited by 17 publications

References 13 publications

Fertility in male patients with advanced Hodgkin lymphoma treated with BEACOPP: a report of the German Hodgkin Study Group (GHSG)

Fertility in male patients with advanced Hodgkin lymphoma treated with BEACOPP: a report of the German Hodgkin Study Group (GHSG)

Impact of lymphoma treatments on spermatogenesis and sperm deoxyribonucleic acid: a multicenter prospective study from the CECOS network

Study of the prevalence of azoospermia in patients with Hodgkin′s lymphoma prior to treatment

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