Evaluation of semen parameters in semen donors in a ten-year period in the city of São Paulo

Glina, Sidney; Nova, Thiago; Brand, Vera Beatriz F.; Molina, Erica; Galuppo, Andrea Giannotti; Correa, Nadeje Regina; Moreira, Frederico Rafael

doi:10.1590/s1679-45082010ao1546

Cited by 6 publications

(8 citation statements)

References 21 publications

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“…A previous Brazilian study retrospectively investigated the quality of donated semen samples and a decline in both sperm count and normal sperm morphology was observed ( 8 ). To our knowledge, such an investigation has never been conducted in Brazilian sub fertile couples attending an assisted fertilization center for conventional semen analysis.…”

Section: Introductionmentioning

confidence: 99%

Decline in semen quality among infertile men in Brazil during the past 10 years

Borges¹,

Setti²,

Braga³

et al. 2015

Int. braz j urol.

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Purpose:To investigate whether the semen quality of men undergoing conventional semen analysis is deteriorating over time.Materials and Methods:We analyzed and compared the sperm count, motility and morphology of 2300 semen samples provided by males undergoing conventional seminal analysis, from years 2000 to 2002 and 2010 to 2012. The incidences of severe oligozoospermia and azoospermia over time were also compared.Results:A total of 764 sperm samples were analyzed in 2000-2002 and 1536 in 20102012. Over time, the mean sperm concentration/ml decreased significantly from 61.7 million in 2000-2002 to 26.7 million in 2010-2012 (R2=11.4%, p<0.001), the total sperm concentration decreased significantly from 183.0 million to 82.8 million (R2=11.3%, p<0.001), and the percentage of normal forms decreased significantly from 4.6% to 2.7% (R2=9.8%, p<0.001). The incidence of severe oligozoospermia significantly increased from 15.7% to 30.3% (OR: 1.09, p<0.001) and the incidence of azoospermia increased from 4.9% to 8.5% (OR: 1.06, p=0.001).Conclusions:This study demonstrated a significant time-related decline in semen quality of infertile patients. This finding might have implications on fertility and emphasizes the need for further studies addressing subject's life-style in order to find and reduce the causative agents. Future prospective and multicenter studies including representative samples of the general population are needed to confirm whether semen quality is really declining.

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Section: Introductionmentioning

confidence: 99%

Decline in semen quality among infertile men in Brazil during the past 10 years

Borges¹,

Setti²,

Braga³

et al. 2015

Int. braz j urol.

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“…From 1973 to 2011, authors reported a 50-60% decline in male sperm concentration in North America, Europe, Australia, and New Zealand 6 . In Brazil, some authors have also published data on declining concentrations and percentage of morphologically normal sperm 7,8 . Possible reasons for these changes in seminal parameters may be related to lifestyle, habits, age, alcohol or tobacco consumption, as well as endocrine factors, obesity, diet, and coffee consumption 9 .…”

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confidence: 99%

Changes in seminal parameters among Brazilian men between 1995 and 2018

Siqueira

Ropelle

Nascimento

et al. 2020

Sci Rep

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Aiming to investigate trends in seminal parameter values among Brazilian men between 1995 and 2018, we performed a retrospective analysis of spermograms of couples admitted for infertility testing at UNICAMP/Brazil. For the present study, only the first sample produced by each man was analyzed (9,267 samples). Total motile sperm count (TMSC), percentage of spermatozoa with normal morphology (NM), and sperm concentration after seminal processing (SCA) were considered dependent variables. Statistical analysis was carried out through linear regression for the median values both in the general population and in the population categorized by age group (<30, 30-39, and ≥40 years). During the study period, the mean age of men was 32.46 (± 6.48) years, with a median of 32 (18-67) years. We found a significant decrease in the median values of TMSC (reduction of 2.84 million/year), NM (reduction of 0.52% each year) and SCA (reduction of 0.24 million/mL each year). In conclusion, we observed that Brazilian men undergoing infertility investigation had a decline in seminal parameters in the past 23 years. Surveillance should be maintained in the coming years, and further studies are needed to elucidate possible causes for seminal deterioration and to devise strategies to reverse this trend.

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“…To date, only a single study has evaluated sperm concentration, motility and morphology over a prolonged period in a group of South American (Latin American) men. In this study, conducted between 1992 and 2003 in the city of São Paulo on 182 Brazilian semen donors, a significant reduction in sperm concentration and normal morphology was found (Glina et al, 2010).…”

Section: Introductionmentioning

confidence: 65%

“…However, the results are contradictory and many critics negate this hypothesis as some studies have shown no decrease in semen quality in recent years (Benshushan, Shoshani, Paltiel, Schenker, & Lewin, 1997;Marimuthu, Kapilashrami, Misro, & Singh, 2003). In this study, conducted between 1992 and 2003 in the city of São Paulo on 182 Brazilian semen donors, a significant reduction in sperm concentration and normal morphology was found (Glina et al, 2010). Very little information is available on longitudinal studies on the semen quality in Latin American countries.…”

Section: Introductionmentioning

confidence: 81%

The Uruguayan semen donor population: A twenty‐eight‐year retrospective study

Barrera¹,

Ordoqui²,

Montes³

et al. 2019

Andrologia

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Several studies have reported a global decline in seminal quality over the years. The objective of this study was to describe the semen donor population of Uruguay through comparing data of successive samples banked by the same donors and the analysis of their semen and physical characteristics, ancestry origin and educational level. A total of 3,449 ejaculated samples collected from 71 donors, cryobanked between 1989 and March 2017 at Fertilab, were analysed. Results revealed a mean age of 23.90 ± 3.98 years, an average weight of 74.95 ± 1.09 kg and a mean height of 1.78 ± 0.06 m. The majority of the donors trace their origin to Europe (74.65%, 53/71) and 66.19% (47/71) have a level of education higher than secondary school.We observed longitudinal differences in two parameters, that is sperm concentration and semen volume. Sperm concentration declined, while semen volume increased significantly over the 28-year period. The results of the present study are in accordance with that of previous articles that also reported a decline in sperm concentration over time. However, no differences were observed in total sperm number per ejaculate due to the increase in semen volume values, thus reflecting no real changes in sperm production over time. K E Y W O R D Sbanking, cryopreservation, donor, spermatozoa

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Evaluation of semen parameters in semen donors in a ten-year period in the city of São Paulo

Cited by 6 publications

References 21 publications

Decline in semen quality among infertile men in Brazil during the past 10 years

Decline in semen quality among infertile men in Brazil during the past 10 years

Changes in seminal parameters among Brazilian men between 1995 and 2018

The Uruguayan semen donor population: A twenty‐eight‐year retrospective study

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