Evaluation of sensitization to the crude extract of Dermatophagoides farinae and its derived allergens, Der f 2 and Zen 1, in dogs with atopic dermatitis in Southern Brazil

Ludwig, Lucas André; Tsukui, Toshihiro; Kageyama, Megumi; Farias, Marconi Rodrigues de

doi:10.1016/j.vetimm.2021.110199

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…House dust mites remain the most common cause of cAD worldwide 48,53–56 . Currently, Der f 2, Der f 15, Der f 18 and Zen 1 are considered the major HDM allergens for cAD 70,72,73,80–87 …”

Section: Discussionmentioning

confidence: 99%

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Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Hensel,

Saridomichelakis,

Eisenschenk

et al. 2023

Veterinary Dermatology

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BackgroundCanine atopic dermatitis (cAD) is a common, complex and multifactorial disease involving, among others, genetic predisposition, environmental factors and allergic sensitisation.ObjectiveThis review summarises the current evidence on the role of genetic and environmental factors and allergic sensitisation in the pathogenesis of cAD since the last review by ICADA in 2015.Materials and MethodsOnline citation databases and proceedings from international meetings on genetic factors, environmental factors and allergens relevant to cAD that had been published between 2015 and 2022 were reviewed.ResultsDespite intensive research efforts, the detailed genetic background predisposing to cAD and the effect of a wide range of environmental factors still need more clarification. Genome‐wide association studies and investigations on genetic biomarkers, such as microRNAs, have provided some new information. Environmental factors appear to play a major role. Lifestyle, especially during puppyhood, appears to have an important impact on the developing immune system. Factors such as growing up in a rural environment, large size of family, contact with other animals, and a nonprocessed meat‐based diet may reduce the risk for subsequent development of cAD. It appears that Toxocara canis infection may have a protective effect against Dermatophagoides farinae‐induced cAD. House dust mites (D. farinae and D. pteronyssinus) remain the most common allergen group to which atopic dogs react. Currently, the major allergens related to D. farinae in dogs include Der f 2, Der f 15, Der f 18 and Zen 1.Conclusions and Clinical RelevanceCanine atopic dermatitis remains a complex, genetically heterogeneous disease that is influenced by multiple environmental factors. Further, well‐designed studies are necessary to shed more light on the role of genetics, environmental factors and major allergens in the pathogenesis of cAD.

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Section: Discussionmentioning

confidence: 99%

“…The HDM D. pteronyssinus ( Der p 1 and Der p 2) and D. farinae ( Der f 1 and Der f 2) are considered the major allergens in humans, 79 while in dogs Der f 2, Der f 15, Der f 18 as well as Zen 1 seem to be more relevant, as indicated by several studies 70,72,73,80–87 …”

Section: Allergensmentioning

confidence: 98%

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Hensel,

Saridomichelakis,

Eisenschenk

et al. 2023

Veterinary Dermatology

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Seroprevalence of Dermatophagoides farinae-specific IgE in dogs with atopic dermatitis in São Paulo, Brazil

Frezza,

Lourenço,

Meira

et al. 2023

Research in Veterinary Science

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Allergen sensitization patterns concerning different governorates in Egypt: a retrospective study

Abdelwahab,

El-Maksoud,

Elhosiny

et al. 2024

Egypt J Chest Dis Tuberc

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Background Allergic disorders afflict 22% of the world’s population. Treatment and prevention of allergic diseases are dependent on correctly identifying the causal allergens and implementing appropriate avoidance approaches. We aimed to assess the variation in patterns of allergen sensitization among patients with allergic disorders in different Egyptian governorates. Methods This retrospective study included patients with allergic disorders attending an allergen immunotherapy outpatient clinic. Demographic data, diagnosis of allergic disorders, and skin prick test results of enrolled patients were retrieved from the medical records. Also, patients’ place of residence was recorded by the governorate. Results This study included 5024 patients with allergic disorders. Most of the studied patients were sensitized to mold (94.3%) followed by house dust mites (74.7%) and hay dust (69%). There was no statistical difference in allergen sensitization patterns in different Egyptian governorates. However, there was a statistically significant relation between allergic rhinitis and mixed pollen 1 (P value 0.02) and mite (P value 0.001). For bronchial asthma, both dog hair and chicken feather sensitization patterns showed a strong association with P values 0.02 and 0.03, respectively. Atopic dermatitis had a significant association with both mites (P value 0.001) and barely (P value 0.02). Conclusion The sensitization patterns did not significantly differ between the Egyptian governorates. However, it is significantly associated with allergic disorders. The most prevalent sensitization pattern in Egypt was mold.

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Evaluation of sensitization to the crude extract of Dermatophagoides farinae and its derived allergens, Der f 2 and Zen 1, in dogs with atopic dermatitis in Southern Brazil

Cited by 3 publications

References 51 publications

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Seroprevalence of Dermatophagoides farinae-specific IgE in dogs with atopic dermatitis in São Paulo, Brazil

Allergen sensitization patterns concerning different governorates in Egypt: a retrospective study

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